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| 1 | Early prediction of pathological outcomes to neoadjuvant chemotherapy in breast cancer patients using automated breast ultrasound显示文摘Objective: Early assessment of response to neoadjuvant chemotherapy(NAC) for breast cancer allows therapy to be individualized.The optimal assessment method has not been established.We investigated the accuracy of automated breast ultrasound(ABUS) to predict pathological outcomes after NAC.Methods: A total of 290 breast cancer patients were eligible for this study.Tumor response after 2 cycles of chemotherapy was assessed using the product change of two largest perpendicular diameters(PC) or the longest diameter change(LDC).PC and LDC were analyzed on the axial and the coronal planes respectively.Receiver operating characteristic(ROC) curves were used to evaluate overall performance of the prediction methods.Youden's indexes were calculated to select the optimal cut-off value for each method.Sensitivity, specificity,positive and negative predictive values(PPV and NPV) and the area under the ROC curve(AUC) were calculated accordingly.Results: yp T0/is was achieved in 42 patients(14.5%) while yp T0 was achieved in 30 patients(10.3%) after NAC.All four prediction methods(PC on axial planes, LDC on axial planes, PC on coronal planes and LDC on coronal planes) displayed high AUCs(all>0.82), with the highest of 0.89 [95% confidence interval(95% CI), 0.83–0.95]when mid-treatment ABUS was used to predict final pathological complete remission(p CR).High sensitivities(85.7%–88.1%) were observed across all four prediction methods while high specificities(81.5%–85.1%) were observed in two methods used PC.The optimal cut-off values defined by our data replicate the WHO and the RECIST criteria.Lower AUCs were observed when mid-treatment ABUS was used to predict poor pathological outcomes.Conclusions: ABUS is a useful tool in early evaluation of p CR after NAC while less reliable when predicting poor pathological outcomes. | Xinguang Wang Ling Huo Yingjian He Zhaoqing Fan Tianfeng Wang Yuntao Xie Jinfeng Li Tao Ouyang | 2016 | Chinese Journal of Cancer Research2016，28，5： | 11 |
| 2 | Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility显示文摘瞄准:在 ubiquitin 特定的朊酶学习单个核苷酸多型性的发生 26 (USP26 ) 在在中国的自发的男不孕的基因和它的参与。方法:平淡的精液分析被执行。不孕因素象免疫学的那样,传染、生物化学的混乱被检验与自发的不孕选择病人。DNA 从选择病人和控制人口的外部血被孤立,它用聚合酶链反应单人赛海滨符合构造多型性分析为变化被检验。而且,核苷酸序列在一些病人和控制被定序。结果:41 个不肥沃的人, 9 (22.0% , P = 0.01 ) 在 X 染色体上的 USP26 基因的有的变化。一个复合变化(364insACA;460G → A ) 在 8 个病人被检测(19.5% , P = 0.01 ) 并且 1044T → A 替换在 1 个病人被发现(2.4% , P >
0.05 ) 。所有三个变化在编码氨基酸导致了变化。二替换预言一些变化:460G → A 把缬氨酸变成异白氨酸,并且 1044T → A 用白氨酸代替本氨基丙酸。三核苷酸 ACA 的另一插入引起 threonine 的插入。没有另外的变化在留下的病人和肥沃的控制被发现。结论:USP26 基因可能具有在男复制的重要性。在这基因的变化可能与男不孕被联系,并且可能否定地影响阴囊的功能。关于这个问题的进一步的研究在进行中。 | Jie Zhang Shu-Dong Qiu Sheng-Bin Li Dang-Xia Zhou Hong Tian Yong-Wei Huo Ling Ge Qiu-Yang Zhang | 2007 | Asian Journal of Andrology2007，9，6： | 10 |
| 3 | Effect of two intensive insulin therapy regimens on perioperative glycemic control in bone fracture patients with type 2 diabetes mellitus显示文摘 | DENG Wei HUO Li-li LAN Ling LU Yan-wei WANG Man-yi | 2013 | Chinese Medical Journal2013，，11： | 7 |
| 4 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 5 | Cerebral vasculopathy in a Chinese family with neurofibromatosis type Ⅰ mutation显示文摘Neurofibromatosis type I(NF1)is a hereditary,autosomal dominant,neurocutaneous syndrome that is attributed to NF1 gene mutation.NF1 has been associated with scoliosis,macrocephaly,pseudoarthrosis,short stature,mental retardation,and malignancies.NF1-associated vasculopathy is an uncommon and easily-overlooked presentation.Examination of a Chinese family affected by NF1combined with cerebral vessel stenosis and/or abnormality suggested a possible relationship between NF1 and vessel stenosis.To determine which NF1 gene mutation is associated with vascular lesions,particularly cerebral vessel stenosis,we examined one rare family with combined cerebral vessel lesions or maldevelopment.Vascular lesions were detected using transcranial Doppler sonography and digital subtraction angiography in family members.Next,denaturing high-performance liquid chromatography and sequencing were used to screen for NF1 gene mutations.The results revealed a nonsense mutation,c.541C>T,in the NF1 gene.This mutation truncated the NF1 protein by 2659 aminoacid residues at the C-terminus and co-segregated with all of the patients,but was not present in unaffected individuals in the family.Exceptionally,three novel mutations were identified in unaffected family members,but these did not affect the product of the NF1 gene.Thus the nonsense mutation,c.541C>T,located in the NF1 gene could constitute one genetic factor for cerebral vessel lesions. | Jian-Tao Liang Li-Rong Huo Yu-Hai Bao Zhen-Yu Wang Feng Ling | 2013 | Neuroscience Bulletin2013，29，6： | 3 |
| 6 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 7 | Prediction of stable BC_(3)N_(2)monolayer from first-principles calculations:Stoichiometry,crystal structure,electronic and adsorption properties显示文摘In this paper,a novel BC_(3)N_(2)monolayer has been found with a graphene-like structure using the developed particle swarm optimization algorithm in combination with ab initio calculations.The predicted structure meets the thermodynamical,dynamical,and mechanical stability requirements.Interestingly,the BC_(3)N_(2)plane shows a metallic character.Importantly,BC_(3)N_(2)has an in-plane stiffness comparable to that of graphene.We have also investigated the adsorption characteristics of CO_(2)on pristine monolayer and Mo functionalized monolayer using density functional theory.Subsequently,electronic structures of the interacting systems(CO_(2)molecule and substrates)have been preliminarily explored.The results show that Mo/BC_(3)N_(2)has a stronger adsorption capacity towards CO_(2)comparing with the pristine one,which can provide a reference for the further study of the CO_(2)reduction mechanism on the transition metal-functionalized surface as well as the new catalyst’s design. | Jiahui Yu Chaozheng He Chunying Pu Ling Fu Dawei Zhou Kun Xie Jinrong Huo Chenxu Zhao Lingmin Yu | 2021 | Chinese Chemical Letters2021，32，10： | 2 |
| 8 | Epitaxial growth of hyperbranched Cu/Cu2O/CuO coreshell nanowire heterostructures for lithium-ion batteries显示文摘nano 建筑学的小心的设计和期望的活跃材料的聪明的杂交能导致更先进的性质。这里,我们设计了新奇层次分叉 Cu/Cu 2 由联合一个灵巧的热水的方法和随后的控制氧化过程的 O/CuO heteronanostructure。在分支和脊梁之间的好结构和取向附生的关系被高分辨率的传播电子显微镜学调查。而且,分支生长的进化也在 Cu nanowire 表面的渐渐的氧化期间被观察了。试验性的结果建议经由二拍子的圆舞暴露进程要表现到改变湿度以便完成的表面氧化需要优化了核心壳的形成结构化的分叉的建筑学。最后,象在锂离子电池的阳极材料的如此的一个层次框架的功能的 proof-of-concept 被表明。分叉的核心壳 heterostructure 由几个工具改进电池性能:取向附生地成年的分支提供的(i) 为到卷变化的提高的电解质可接近性和高抵抗的一个高表面区域由 Li+ 置闰 / 抽取导致了;(ii ) 有它的明确的异质接面的核心壳结构增加在 lithiation 期间便于有效费用运输的接触区域;(iii ) 铜核心象提供结构的加强一样充当一个当前的收集者。 | Yuxin Zhao Ying Zhang Hu Zhao Xuejin Li Yanpeng Li Ling wen Zifeng Yan Ziyang Huo | 2015 | Nano Research2015，8，8： | 2 |
| 9 | Study of the External Dose Rate and Retained Body Activity of Patients with Hyperthyroidism Who Are Receiving Ⅰ-131 Therapy显示文摘Hyperthyroidism refers to a clinical state that results from inappropriately high thyroid hormone levels in the tissues[1]. Ⅰ-131 therapy plays a critical role and provides a remarkable curative effect in targeting thyroid diseases. Thyroid cells can take up isotope Ⅰ-131, which emits not only beta rays but also gamma rays. Beta rays are used for killing thyroid cancer cells and for destroying a number of glandular tissues, which is a key in achieving treatment goals. However, gamma rays with strong ionizing radiation effects can cause radioactive contamination, which causes radiation hazard to other individuals who come into contact with patients. Radiation can induce carcinogenesis, such as leukemia and skin cancer. Therefore, more and more attention is being paid to radiation safety and protection against the radiation hazard from Ⅰ-131[2, 3]. | LIU Yu Lian ZHAO Zhi Xin HUO Meng Hui YIN Chen TAN Jian ZHANG Wen Yi JIAO Ling | 2018 | Biomedical and Environmental Sciences2018，31，12： | 2 |
| 10 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 11 | Characteristics of the macula in amblyopic eyes by optical coherence tomography显示文摘AIM: To test the hypothesis that amblyopic neuroretina may have an altered thickness when compared to the normal. · METHODS: Twenty-five amblyopic, young patients between the ages of 7 and 11 years old were studied. The interested neuroretina areas are defined into 10 sub-regions according to superior-inferior, nasal-temoral, and peri-para axis, which cross the fovela structure. The thicknesses of ten, defined macular regions were separately measured by optical coherence tomography (OCT) and analyzed by t-test. · RESULTS: The average thickness of neuroretina in the exact foveola of the amblyopic eyes is larger than that of normal eyes (P <0.05), but the other nine regions have no significant difference. Interestingly, in both the normal and amblyopic eyes, the temporal area looks thinner than other quadrants (P <0.05). · CONCLUSION: Thickness alteration may be associated with amblyopic disorders in young patients. Studying a larger volume of subjects of similar age is required to confirm this observation. | Xin-Mei Wang, Jun-Wen Zeng | 2012 | International Journal of Ophthalmology(English edition)2012，5，2： | 2 |
| 12 | The Cauchy Problem for the Generalized Korteweg-de Vries-Benjamin-Ono Equation with Low Regularity Data显示文摘概括 Korteweg-de Vries-Benjamin-Ono 方程的 Cauchy 问题被考虑,并且答案的低整齐和限制行为被获得。为 k = 1,本地 well-posedness 在 H^s (R) 为数据被获得(s >-(3/4)) 。为 k = 2,数据 inH^s (R)(s ≥ 1/4 ) 的本地结果被获得。为 k = 3,在 H^s (R) 的数据的本地结果(s >-(1/6)) 被获得。而且,如果 Benjamin-Ono 方程的学期趋于到零,概括 Korteweg-de Vries-Benjamin-Ono 方程的答案收敛到 KdV 方程的答案。 | Zhao Hui HUO Bo Ling GUO | 2005 | Acta Mathematica Sinica,English Series2005，21，5： | 2 |
| 13 | Associative vs. dissociative mechanism: Electrocatalysis of nitric oxide to ammonia显示文摘Nitric oxide reduction to ammonia by electrocatalysis is the potential application in the elimination of smog and energy conversion. In this work, the feasibility of the application of two-dimensional metal borides(MBenes) in nitric oxide electroreduction reaction(NOER) was investigated through density functional theory calculations. Including the geometry and electronic structure of five kinds of MBenes, the adsorption of NO on the surface of these substrates, the selective adsorption of hydrogen protons during the hydrogenation process, and the overpotential in the electrocatalytic ammonia synthesis process. As a result, Mn B exhibited the most favorable catalytic performance according to the associative pathways,which is thermodynamically performed spontaneously, and WB has a minimum overpotential of 0.37 V vs. RHE in the process of ammonia production according to the dissociative pathway. Overall, our work is the first to explore the electrocatalytic NO through the dissociative mechanism to synthesize ammonia in-depth and proves that MBenes are efficient NO electrocatalytic ammonia synthesis catalysts. These research results provide a new direction for the development of electrocatalytic ammonia synthesis experimentally and theoretically. | Chaozheng He Jia Wang Ling Fu Chenxu Zhao Jinrong Huo | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 14 | MreBCD-associated Cytoskeleton is Required for Proper Segregation of the Chromosomal Terminus during the Division Cycle of Escherichia Coli显示文摘 | Yu-Jia Huo Ling Qiao Xiao-Wei Zheng Cheng Cui Yuan-Fang Ma Feng Lu | 2015 | Chinese Medical Journal2015，，9： | 2 |
| 15 | First-principles study on Fe_(2)B_(2)as efficient catalyst for nitrogen reduction reaction显示文摘[18_(T)D$IF]Ammonia(NH_(3))is considered an attractive candidate as a clean,highly efficient energy carrier.The electrocatalytic nitrogen reduction reaction(NRR)can reduce energy input and carbon footprint;therefore,rational design of effective electrocatalysts is essential for achieving high-efficiency electrocatalytic NH_(3)synthesis.Herein,we report that the enzymatic mechanism is the more favourable pathway for NRR,due to lower limiting potential(-0.44 V),lower free energy(only 0.02 eV)of the first hydrogenation step(*N–N to*NH–N),and more electron transfer from Fe_(2)B_(2)to the reaction species.In addition,both vacancies and dopants can be helpful in reducing the reaction energy barrier of the potential-determining step.Therefore,we have demonstrated that Fe_(2)B_(2)is a potential new candidate for effective NRR and highlighted its potential for applications in electrocatalytic NH_(3)synthesis. | Wei Song Jia Wang Ling Fu Chaozheng He Chenxu Zhao Yongliang Guo Jinrong Huo Guohui Dong | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 16 | Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis显示文摘 | Fu Yang Xi-song Huo Sheng-xian Yuan Ling Zhang Wei-ping Zhou Fang Wang Shu-han Sun | 2013 | Molecular Cell2013，，2： | 1 |
| 17 | Purifieation of glycyIxhizin from Glycyrrhiza uralensis Fisch with ethanol/phosphate aqueous two phase system显示文摘 | Tan Tianwel Huo Qing Ling Qiang | 2002 | Bioteehnol Lett2002，24，： | 1 |
| 18 | Capture and separation of CO_(2)on BC_(3)nanosheets:A DFT study显示文摘In order to reduce the greenhouse effect caused by the rapid increase of CO_(2)concentration in the atmosphere,it is necessary to develop more efficient,controllable,and highly sensitive adsorbing materials.In this study,the adsorption behavior of CO_(2)on BC_(3)nanosheets under an external electric field was explored based on density functional theory(DFT).It was found that CO_(2)experienced a transition from physisorption to chemisorption in the electric field range of 0.0060-0.0065 a.u..In addition,the adsorption/desorption of CO_(2)is reversible and can be precisely controlled by switching on/off at the electric field of 0.0065 a.u..The selective adsorption of CO_(2)/H_(2)/CH_(4)by BC_(3)can also be used to realize gas separation and purification under different electric fields.This study highlighted the potential application of BC_(3)nanosheets as a high-performance,controllable material for CO_(2)capture,regeneration,and separation in an electric field. | Houyong Yang Chaozheng He Ling Fu Jinrong Huo Chenxu Zhao Xiuyuan Li Yan Song | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 19 | Anfimicrobial and DNA- binding activities of the peptide fragments of human lacto- ferrin and histatin 5 against Streptococcus mutans显示文摘 | Huo L Zhang K Ling J | 2011 | Arch OralBiol2011，56，9： | 1 |
| 20 | Purification of glycyrrhizin from Glycyrrhiza uralensis Fisch with ethanol / phosphate aqueous two phase system 显示文摘 | Tan Tianwei Huo Qing Ling Qiang | 2002 | Biotechnol Lett2002，24，： | 1 |
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