|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 2 | A new lignan and active compounds inhibiting NF-κB signaling pathway from Caulis Trachelospermi显示文摘A new dibenzylbutyrolactone lignan named matairesinol 4'-O-β-D-cellobioside(1),together with a known compound(7R,85)-dihydrodehydrodiconiferyl alcohol(2)was isolated from Caulis Trachelospermi.The extract of Caulis Trachelospermi,which was separated by 80% alcohol extraction and subsequent HP-20 macroporous resin column chromatography,and its main components trachelogenin(3),nortrachelogenin(4),matairesinol(5)showed moderate inhibiting activities on NF-κB signaling pathway induced by TNFα,with the IC_(50) values of 17.7μg/mL,17.9μM,49.4μM and 29.1μM,respectively. | Chencheng Zhu LingJing Nengjiang Yu Xuedong Yang Yimin Zhao | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 6 |
| 3 | Primary Screening of 10-Hydroxy-2-Decenoic Acid Productive Strains显示文摘In this paper, eleven strains, which were screened strictly from raw royal jelly, soil andhoneycomb etc. by meansof dilution plate and spread plate methods, were cultured at 28℃ for 60 h with shaking. To determine whether they could yield10-Hydroxy-2-decenoic acid during fermentation, gas chromatography and gas chromatography-mass spectrometry methodswere used. The results showed that the strains BH002 and BH004, were both identified as Crytococcaceae, where BH002was primarily classified into Candida for possessing the abilities. The 10-HDA productivity of Candida BH002 and that ofBH004 were 0.327% and 0.2648% respectively. | Bailin Li Yongxin Kang Lingjing Wei Lizhen HuangFaculty of Food Science & Technology Shanghai Fisheries University Shanghai 200090 | 2002 | 食品科学2002，23，8： | 4 |
| 4 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 5 | Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells显示文摘Background:Mesencephalic astrocyte-derived neurotrophic factor(MANF)is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress(ER stress).HSP70 family,a chaperon like heat shock protein family,was proved to be involved in the MANF induced survival pathway in 6-OHDA treated SHSY-5Y cells.However,the ER stress relative transcriptome,in MANF signaling cascades is still investigated.The involvement of HSP70,a 70kd member of HSP70 family,need further to be verified.Methods:The cell apoptosis was assayed by MTT,TUNEL staining and western blot of cleaved Caspase-3.The differentially expressed genes in SHSY-5Y cells under different conditions(control,6-OHDA,6-OHDA+MANF)were investigated by RNA-seq.Expression of HSP70 was further confirmed by real-time PCR.RNAi knockdown for HSP70 was performed to investigate the role of HSP70 in the MANF signaling pathway.Results:MANF inhibits 6-OHDA-induced apoptosis in SHSY-5Y cells.Six ER stress relative genes(HSP70,GRP78,xbp-1,ATF-4,ATF-6,MAPK)were found enriched in 6-OHDA+MANF treatment group.HSP70 was the most significantly up-regulated gene under 6-OHDA+MANF treatment in SHSY-5Y cells.RNAi knockdown for HSP70 inhibits the protective effects of MANF against 6-OHDA toxicity in SHSY-5Y cells.Conclusion:MANF exerts a protective role against 6-OHDA induced apoptosis in SHSY-5Y cells via up-regulating some ER stress genes,including HSP70 family members.The HSP70 expression level plays a key role in MANFmediated survival pathway. | Hui Sun Ming Jiang Xing Fu Qiong Cai Jingxing Zhang Yanxin Yin Jia Guo Lihua Yu Yun Jiang Yigang Liu Liang Feng Zhiyu Nie Jianmin Fang Lingjing Jin | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 6 | The role of versican G3 domain in regulating breast cancer cell motility including ef- fects on osteoblast cell growth and differentiation in vitro-evalua- tion towards understanding breast cancer cell bone metastasis显示文摘 | Du William Fang Lingj Yang Weining | 2013 | BMC Cancer2013，12，1： | 1 |
| 7 | Online Persuasion : How The Written Word Drives WOM 显示文摘 | Li Jin And Lingjing Zhan | 2011 | Journal Of Advertising Research2011，51，1： | 1 |
| 8 | Screening of Tag SNPs and predic- tion of their potential function in genetic studies of complex disea- ses[J]显示文摘 | ZHUYM XUYY LINGJ | | 浙江大学学报:医学版0，，： | 1 |
| 9 | A Study of CFL Teacher Competency in the U.S.: An Overview of Professional Guidelines, Resources, and Standards显示文摘Chinese as a foreign language (CFL) is a critical language in the United States, and the importance to have competent CFL teachers has been more and more realized. However, the literature does not show sufficient research on CFL teacher competency. To fill the gap, a series of exploratory research studies are initiated. As a part of the initiation, this study overviews the professional guidelines, resources, standards and requirements for CFL education in the U.S. at the national and state levels. The findings will be useful for designing teacher education program and teacher training program. In addition, student teachers, pre-service teachers, and in-service teachers can also use them as great references for their academic and/or professional development. | Haixia WANG Gang LIU Shunqin LI Lingjing LUO | 2018 | 汉语教学方法与技术2018，1，2： | 1 |
| 10 | Anengineeringmethodforreliabilityanalysisofmechanicalstructuresforlongfatiguelives显示文摘 | LingJ PanT | 1997 | Relia-bilityEngineering&SystemSafety1997，56，2： | 1 |
| 11 | A Chebyshev Spectral Method for Solving Riemann-Liouville Fractional Boundary Value Problems显示文摘 | GraefJ R KONG Lingj u WANG Min | 2014 | Appl Math Comput2014，2410，： | 1 |
| 12 | et al Increasing vitamin C content of plants through enhanced ascorbate recycling显示文摘 | Chen Z Young T Z LingJ | 2003 | Proceedings of the National Academy of Sciences2003，100，： | 1 |
| 13 | Expression of Renin‐Angiotensin System and Peroxisome Proliferator‐Activated Receptors in Alcoholic Cardiomyopathy显示文摘 | LingJing Wei‐MinLi Li‐JunZhou ShuangLi Jun‐JieKou JianSong | 2008 | Alcoholism: Clinical and Experimental Research2008，，11： | 1 |
| 14 | Environmental enrichment induces synaptic structural modification after transient focal cerebral Ischemia in rats 显示文摘 | Xiaohong Xu Lingjing Ye Qin Ruan | 2009 | Exp Biol Med ( Maywood )2009，234，3： | 1 |
| 15 | Analysis of patients with medicalknowledge impact antimicrobial prescription 显示文摘 | LINGJ ZHANGW | 2013 | 中华医院管理学杂志2013，29，11： | 1 |
| 16 | Fluorescent nanoparticle beacon for logic gate operation regulated by strand dis- placement显示文摘 | Jing Yang Lingjing Shen | 2013 | ACS Appl Mater Interfaces2013，5，： | 1 |
| 17 | Understanding luxury consumption in China: Consumer perceptions of best-known brands显示文摘 | Lingjing Zhan Yanqun He | 2011 | Journal of Business Research2011，，10： | 1 |
| 18 | Impact of organic carbon on nitrification perform-ance of different biofilteis显示文摘 | LingJ Chen S L | 2005 | Aquacultural Engineering2005，33，： | 1 |
| 19 | Stableandunstabletransgeneintegrationsitesinthehumange-nome:ExtinctionofthegreenfluorescentproteintransgeneinK562cells显示文摘 | MIGLIACCIOAR BENGRAC LINGJ etal | 2000 | Gene2000，256，12： | 1 |
| 20 | Regularized local linear prediction of chaotic time series显示文摘 | Lingj(ae)rde O C Christophersen N | 1998 | Physica D1998，112，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员