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您的检索式：作者名="Lingge Cheng"
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| 1 | Perfolmance analysis of vertical handoff strategy for heterogeneous overlay network显示文摘 | Hongyan Bing Cheng He Lingge Jiang | 2004 | Chinese Journal of Electlonics2004，13，4： | 1 |
| 2 | Compounding effects of human activities and climatic changes on coexistence of oasis-desert ecosystems:Prioritizing resilient decision-making for a riskier world显示文摘Water-salt balance is critical for the stable coexistence of salt-affected and groundwater-fed oasis-desert ecosystems. Yet, a comprehensive investigation of how soil salinization and groundwater degradation threaten the coexistence of oasis-desert ecosystems is still scarce, especially under the compounding effects of human activities and climatic changes. Here, we assessed the impacts of irrigated agriculture on hydrological regimes in oasisdesert systems, investigated the spatio-temporal variations of soil salinization in irrigated cropland, and evaluated the implications of the interplays of soil salinization and groundwater degradation on the coexistence of oasis-desert ecosystems in northwestern China, based on meaningful modelling approaches and comprehensive measurements over 1995–2020. The results showed that the irrigation return flow coefficient decreased sharply from 0.21 ± 0.09 in the traditional irrigation period to 0.09 ± 0.01 in the water-saving irrigation period. The continuous drop in groundwater tables and significant degradation of groundwater quality are occurring throughout this watershed. The eco-environmental flows are reaching to their limit with watershed closures(i.e.,the drainage from the oasis region into the desert region is being weakened or even eliminated), although these progressions were largely hidden by regional precipitation and streamflow variability. The process of salt migration and accumulation across different landscapes in oasis-desert system is being reshaped, and soil salinization in water-saving agricultural irrigated lands is accelerating with a regional average annual growth rate of18%. The vegetation in this watershed is degrading, and anthropogenic disturbance accelerates this trend. Our results highlight that environmental stress adaptation strategies must account for resilience maintenance to avoid accelerating catastrophic transitions in oasis-desert ecosystems. Determining the optimal oasis scales and formulating the best irrigation management plans are effective and resilient decision-making ways to maintain the coexistence relationship of oasis-desert ecosystem in drylands. | XinWei Yin Wei Liu Meng Zhu JuTao Zhang Qi Feng HaiYang Xi LinShan Yang Tuo Han WenJu Cheng YingQing Su BaiTing Zhang YuanYuan Xue ZeXia Chen LingGe Wang | 2023 | Research in Cold and Arid Regions2023，15，5： | 0 |
| 3 | Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment显示文摘Vascular abnormality is a hallmark of most solid tumors and facilitates immune evasion.Targeting the abnormal metabolism of tumor endothelial cells(TECs)may provide an opportunity to improve the outcome of immunotherapy.Here,in comparison to vascular endothelial cells from adjacent peritumoral tissues in patients with colorectal cancer(CRC),TECs presented enhanced glycolysis with higher glyceraldehyde-3-phosphate dehydrogenase(GAPDH)expression.Then an unbiased screening identified that osimertinib could modify the GAPDH and thus inhibit its activity in TECs.Low-dose osimertinib treatment caused tumor regression with vascular normalization and increased infiltration of immune effector cells in tumor,which was due to the reduced secretion of lactate from TECs by osimertinib through the inhibition of GAPDH.Moreover,osimertinib and anti-PD-1 blockade synergistically retarded tumor growth.This study provides a potential strategy to enhance immunotherapy by targeting the abnormal metabolism of TECs. | Yunlong Shan Qi Ni Qixiang Zhang Mengying Zhang Bin Wei Lingge Cheng Chongjin Zhong Xinyu Wang Qingqing Wang Jiali Liu Jingwei Zhang Jingjing Wu Guangji Wang Fang Zhou | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
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