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您的检索式：作者名="Lingxia Fei"
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| 1 | Expression of co-stimulatory molecules B7-2 and PD-L1 on peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection显示文摘Objective:To explore the roles of the expression of the co-stimulatory molecule,B7-2,and the co-inhibitory molecule,PD-L1,on peripheral blood mononuclear cells in the mechanism of immunotolerance in chronic hepatitis B virus infection.Methods:Thirty HBV infected patients in the immunoreactive phase and 20 patients in the immunotolerant phase were enrolled in the study,while 20 healthy volunteers were used as controls.RT-PCR and real-time PCR methods were used to detect the expression levels of B7-2 and PD-L1 mRNA in peripheral blood mononuclear cells in chronic HBV infected patients.Results:The B7-2 expression in immunoreactive and immunotolerant patients was significantly lower than that in the controls(P all < 0.01);B7-2 expression in immunoreactive patients was significantly lower than in immunotolerant patients(P < 0.01).PD-L1 expression in immunoreactive patients and immunotolerant patients was significantly higher than that in normal controls(P all < 0.01).The PD-L1/B7-2 ratios in immunoreactive and immunotolerant patients were significantly higher than that of the healthy controls(P all < 0.01);the PD-L1/B7-2 ratio was significantly higher in the immunoreactive patients than in the immunotolerant patients(P < 0.01).Conclusion:In chronic HBV infection,changes in the expression of co-stimulatory and co-inhibitory molecules imply a protective adjustment against the patient's immune response that may result in increased immunotolerance and persistent HBV infection. | Lingxia Fei Shipin Wu Hongtao Chen | 2009 | Journal of Nanjing Medical University2009，23，5： | 0 |
| 2 | Bilateral asymmetric tonic seizure in insuloopercular epilepsy:an anatomo-electroclinical study显示文摘Background:Insulo-opercular seizures are highly heterogeneous in seizure semiology and electrical features.Bilateral asymmetric limb posturing,as a classical pattern of supplementary sensorimotor area(SMA)seizure,also occurs in insulo-opercular epilepsy.This study was aimed to study the anatomo-electro-clinical correlations in bilateral asymmetric tonic seizures(BATS),in order to advance the understanding of insulo-opercular epilepsy.Methods:Eight patients with insulo-opercular epilepsy as confirmed by stereoelectroencephalography(SEEG)and manifesting BATS as the major ictal motor sign,in Guangdong Sanjiu Brain Hospital Epilepsy Center from 2014 to 2018,were employed in this study.The BATS of the patients were evaluated,and the semiologic features and concomitant intracerebral EEG changes were quantified.Then the variables were examined with Cluster Analysis,and the semiologic features were correlated with anatomic localization using the Kendall correlation test.Results:Of the 8 patients,the most frequent initial motor sign was bilateral asymmetric tonic posturing(62.5%).Facial tonic-clonic sign also had a high prevalence in the evolution of seizures(87.5%).The results of Cluster Analysis showed that the semiologic features were subdivided into two main groups,one group comprising exclusively BATS and the other including signs of focal tonic seizure,aura,focal limb tonic-clonic seizure(TCS),facial TCS,hypermotor behavior,eye movement,autonomic changes and generalized TCS.The BATS was strongly associated with the posterior long gyrus(PLG)of insula(t=0.732)and parietal operculum(t=1.000);the hypermotor behaviors were associated with the anterior long gyrus(ALG)(t=0.770);and the autonomic changes were associated with the anterior limiting sulcus(ALS)(t=0.734)and middle short gyrus(MSG)(t=0.700).Conclusions:The seizure semiology of insulo-opercular epilepsy is characterized,in temporal order,by BATS,with or without simultaneous hypermotor behaviors,and frequently ends up with facial tonic-clonic signs,which is different from that of the SMA seizure.The early spread network involving the posterior insular lobe and parietal operculum may contribute to this pattern of manifestation. | Xiangshu Hu Kaihui Li Xiao Wang Ping Yang Qinghua Tan Danfang Li Xiaobo Wang Fang Zeng Yang Jin Lingxia Fei Hua Li Junxi Chen Qiang Guo | 2020 | Acta Epileptologica2020，2，1： | 0 |
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