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| 1 | Generation and Regulation of CD8^+ Regulatory T Cells显示文摘Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8+ cells. Analysis of a small fraction of CD8+ cells that target autoreactive CD4+ cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8+ Treg. Here we summarize recent progress and future directions of research into the role of this CD8+ sublineage in resistance to autoimmune disease. | Linrong Lu Harvey Cantor | 2008 | Cellular & Molecular Immunology2008，5，6： | 22 |
| 2 | Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus显示文摘Dysregulated B-cell activation plays pivotal roles in systemic lupus erythematosus(SLE),which makes B-cell depletion a potential strategy for SLE treatment.The clinical success of anti-CD19 CAR-T cells in treating B-cell malignancies has attracted the attention of researchers.In this study,we aimed to investigate the feasibility of applying anti-CD19 CAR-T cell therapy to SLE treatment in a mouse disease model.We constructed murine anti-CD19 CARs with either CD28 or 4-1BB as the intracellular costimulatory motif and evaluated the therapeutic function of the corresponding CAR-T cells by infusing them into MRL-lpr mice.Furthermore,anti-CD19 CAR-T cells were transferred to MRL-lpr mice before the onset of disease to determine their role in SLE prevention.According to our observations,compared with antibody treatment,the adoptive transfer of our anti-CD19 CAR-T cells showed a more sustained B-cell-depletion effect in MRL-lpr mice.The transfer of syngeneic anti-CD19 CAR-T cells not only prevented disease pathogenesis before the onset of disease symptoms but also displayed therapeutic benefits at a later stage after disease progression.We also tried to optimize the treatment strategy and found that compared with CAR-T cells with the CD28 costimulatory motif,CAR-T cells with the 4-1BB costimulatory motif showed better therapeutic efficiency without cell enrichment.Taken together,these results show that anti-CD19 CAR-T cell therapy was effective in the prevention and treatment of a murine model of SLE,indicating its potential for clinical use in patients. | Xuexiao Jin Qin Xu Chengfei Pu Kaixiang Zhu Cheng Lu Yu Jiang Lei Xiao Yongmei Han Linrong Lu | 2021 | Cellular & Molecular Immunology2021，18，8： | 12 |
| 3 | Determination of the coefficient of rolling friction of irregularly shaped maize particles by using discrete element method显示文摘The coefficient of rolling friction is a foundation parameter for conducting particles simulation,however,which of irregularly shaped maize seeds is difficult to measure.Furthermore,the coefficient of rolling friction between the simulation particles and the actual seeds is inconsistent due to the shaped difference of model and different position of gravity center.This paper use two methods to determinate the coefficient of rolling friction based on discrete element method(DEM)and physical experiments.Three types of maize models from five different shaped maize samples(including horse-tooth shape,spherical cone shape,spherical shape,oblate shape,irregular shape)were developed with the help of slice modeling and 3D modeling technology.Aluminum cylinder container is used to arrange the simulation experiments of angle of repose with taking the coefficient of rolling friction as independent variables and the simulation angle of repose as target values.After predicting detailed the coefficient of rolling friction(including horse-tooth shape,spherical cone shape,spherical shape,between horse-tooth shape and spherical cone shape,between horse-tooth shape and spherical shape,between spherical shape and spherical cone shape maize models),and forecasting a unified the coefficient of rolling friction among horse-tooth shape,spherical cone shape and spherical shape maize models,two types of materials(aluminum cylinder container and organic glass container)were used to validate the difference the angle of repose between the simulation maize models and actual maize seeds.Results show the relative error of the angle of repose between the maize models controlled by the coefficient of rolling friction through the detailed method and the actual maize seeds is 0.22%,0.33%in aluminum cylinder,organic glass container,respectively.The relative error of the angle of repose between the simulation maize models controlled by the coefficient of rolling friction through the united method and actual maize seeds is 2.47%,2.97%in aluminum cylinder,organic glass container,respectively.Although the difference of the angle of repose between two method is smaller,the detailed method is better.Moreover,From the accumulation process of the angle of repose we found that the difference on the contacts number between maize models and bottom plate,the change curve of the rotational kinetic energy,the potential energy of maize models controlled by the coefficient of rolling friction through the detailed and the united method are evidently.We can choose a better method to predict the coefficient of rolling friction of maize seeds according to the application situation and investigation objective of irregular maize seeds.The results can provide a theoretical basis for designing and optimizing the structure of the seed-metering machine with DEM. | Linrong Shi Wuyun Zhao Bugong Sun Wei Sun | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 5 |
| 4 | Effects of Structural Parameters on the Poisson’s Ratio and Compressive Modulus of 2D Pentamode Structures Fabricated by Selective Laser Melting显示文摘Metamaterials have been receiving an increasing amount of interest in recent years. As a type of metamaterial, pentamode materials (PMs) approximate the elastic properties of liquids. In this study, a finite-element analysis was conducted to predict the mechanical properties of PM structures by altering the thin wall thicknesses and layer numbers to obtain an outstanding load-bearing capacity. It was found that as the thin wall thickness increased from 0.15 to 0.45 mm, the compressive modulus of the PM structures increased and the Poisson’s ratio decreased. As the layer number increased, the Poisson’s ratio of the PM structures increased rapidly and reaches a stable value ranging from 0.50 to 0.55. Simulation results of the stress distribution in the PM structures confirmed that stress concentrations exist at the junctions of the thin walls and weights. For validation, Ti–6Al–4V specimens were fabricated by selective laser melting (SLM), and the mechanical properties of these specimens (i.e., Poisson’s ratio and elastic modulus) were experimentally studied. Good consistency was achieved between the numerical and experimental results. This work is beneficial for the design and development of PM structures with simultaneous load-bearing capacity and pentamodal properties. | Lei Zhang Bo Song Ruijie Liu Aiguo Zhao Jinliang Zhang Linrong Zhuo Guiping Tang Yusheng Shi | 2020 | Engineering2020，6，1： | 4 |
| 5 | Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma显示文摘气喘是在多重基因、环境的因素之中包含复杂相互影响的普通过敏混乱。最近的研究作为一个新奇气喘危险性因素识别了人的 GAB1 的基因变体。然而,在肺的 Gab1 的功能仍然保持大部分未经勘探。在这研究,我们首先在尖锐恶化期间从气喘的病人在外部血 mononuclear 房间观察了 Gab1 水平的举起与康复相比。有在 myeloid 的有选择地破坏的 Gab1 的老鼠树枝状的房间(mDCs ) 更加在气喘的试验性的模型稀释了过敏发炎。进一步的调查在 Gab1 缺乏的 mDCs 的调停 CCL19 的移植揭示了突出的减小到排干淋巴节点和驾驶 Th2 的适应激活的随后的缺陷。机械学地, Gab1 是在气喘的回答期间调整 mDC 移植的 CCL19/CCR7 chemokine 轴的一个必要部件。一起,这些调查结果在肺为 Gab1 的角色提供第一条证据,给我们气喘的致病的更深的理解。 | Yun Zhang Yun Xu Shuwan Liu Xiaohong Guo Dong Cen Jiaqi Xu Heyuan Li Kaijun Li Chunlai Zeng Linrong LU Yiting Zhou Huahao Shen Hongqiang Cheng Xue Zhang Yuehai Ke | 2016 | Cell Research2016，26，11： | 3 |
| 6 | Investigation of interaction effect between static and rolling friction of corn kernels on repose formation by DEM显示文摘The coefficient of static friction(SF),the coefficient of rolling friction(RF)for particles are two key parameters affecting the repose angle formation and flow characteristics.In this paper,the interaction effects of SF and RF on the formation process of corn repose angle was investigated by the discrete element method.Firstly,five shape kinds of corn models(horse tooth,spherical cone,spheroid,oblate,and irregular shape)were established.Secondly,aluminum cylinder and organic glass box were used to conduct the simulation experiments with taking SF and RF as independent factors and seeing the repose angle as dependent value.Based on simulation results the regression equations were established.Simulation results showed the relation between two factors and the rotational kinetic energy is not nonlinear,and SF does not significantly restrict the flow of corn models after increasing the flow direction,and the effect of SF on the contact number between corns and the bottom plate is remarkable,while the effect of RF on the contact number is not remarkable.Finally,the interaction effect of two factors on the repose angle was analyzed by variance analysis and results showed SF and RF all have a significant impact on the repose angle.Moreover,their interaction effect has an impact on the repose angle. | Linrong Shi Xiaoping Yang Wuyun Zhao Wei Sun Guanping Wang Bugong Sun | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 2 |
| 7 | Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages显示文摘The nucleotide-binding domain,leucine-rich-repeat containing family,pyrin domain-containing 3(NLRP3)inflammasome is essential in inflammation and inflammatory disorders.Phosphorylation at various sites on NLRP3 differentially regulates inflammasome activation.The Ser725 phosphorylation site on NLRP3 is depicted in multiple inflammasome activation scenarios,but the importance and regulation of this site has not been clarified.The present study revealed that the phosphorylation of Ser725 was an essential step for the priming of the NLRP3 inflammasome in macrophages.We also showed that Ser725 was directly phosphorylated by misshapen(Msn)/NIK-related kinase 1(MINK1),depending on the direct interaction between MINK1 and the NLRP3 LRR domain.MINK1 deficiency reduced NLRP3 activation and suppressed inflammatory responses in mouse models of acute sepsis and peritonitis.Reactive oxygen species(ROS)upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.Eliminating ROS suppressed NLRP3 activation and reduced sepsis and peritonitis symptoms in a MINK1-dependent manner.Altogether,our study reveals a direct regulation of the NLRP3 inflammasome by Msn family kinase MINK1 and suggests that modulation of MINK1 activity is a potential intervention strategy for inflammasomerelated diseases. | Kaixiang Zhu Xuexiao Jin Zhexu Chi Sheng Chen Songquan Wu Richard D.Sloan Xuai Lin Dante Neculai Di Wang Hu Hu Linrong Lu | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 8 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 9 | Study on mechanical properties of soil-rock mixture of various compactness subjected to freeze-thaw cycles显示文摘The soil-rock mixture,a collection of soil particles and rock blocks,is inherently heterogeneous and anisotropic due to significant particle size and material strength differences.This study conducts triaxial tests on soil-rock mixture samples of various compactness subjected to varying freeze-thaw cycles.A mesoscopic simulation is carried out by particle flow code(PFC)to analyze the effects of freeze-thaw cycles on the mechanical properties of soil and rock particles.The results show that the mechanical properties of the soil-rock mixture under freeze-thaw cycles are greatly affected by the initial compaction.In general,when the degree of compaction is higher,the influence of freeze-thaw cycles on the soil-rock mixture is greater.The stress-strain curves of the samples with different compactness demonstrate strain-softening behavior.The freeze-thaw cycles greatly influence the failure strength of the samples with a higher degree of compaction but have little impact on the samples with a lower degree of compaction.On the microscopic level,during freeze-thaw cycles,the pore volume in the highly compacted sample is too small to accommodate the volume expansion from ice crystal formation,causing significant strength loss among the soil and rock particles and deterioration of the macroscopic properties of the soil-rock mixture. | Zhong Zhou HaoHui Ding WenYuan Gao LinRong Xu | 2021 | Research in Cold and Arid Regions2021，13，5： | 2 |
| 10 | Effect of rare earthe lement Ce and La on corrosion behavior of AM60 magnesium alloy显示文摘 | Wenjuan Liu Fahe Cao Linrong Chang | 2009 | Corrosion Science2009，，51： | 1 |
| 11 | Influence of electric parameterson MAO of AZ91D magnesium alloy using alternative square-wave powersource 显示文摘 | Chang Linrong Cao Fahe Cai Jingshun | 2011 | Transactions of Nonferrous Metals Society of China2011，21，： | 1 |
| 12 | Effect of rare earth element Ce and La on corrosion behavior of AM60 magnesiumalloy显示文摘 | Wenjuan Liu Fahe Cao Linrong Chang | 2009 | Corrosion Science2009，，51： | 1 |
| 13 | Analysis of the metering performance for typical shape maize seeds using DEM显示文摘The irregular shape,varying internal compositions,and uneven distributions of maize seeds can degrade the metering performance of maize seeders.This study investigates the effect of irregular maize on the performance of a high-filling-rate seed metering device using DEM.The results show that the seed population in the seed box formed large and small cycles of seed transport due to the disturbances caused by the three wheels.The increasing angular speed of the three wheels reduced the rate of seed filling in the seed filling regions by gravity and disturbances.In addition,an analysis of the repose angle formed by the dropped seed indicated that the angular speed of the taking seed wheel has a certain effect.The large angular speed reduced the coefficient of variation of the seed drop location.The repose angle of the horse tooth seed was greater than those of the other.Meanwhile,the irregular maize seed can also reduce the coefficient of variation of the seed drop location.A comparison between the simulation and experiment results indicates the number of metering seed were basically the same. | Linrong Shi Wuyun Zhao Wei Sun Xiaoping Yang Guanping Wang Shanglong Xin | 2023 | International Journal of Agricultural and Biological Engineering2023，16，1： | 1 |
| 14 | Effect of rare earth element Ce and La on corrosion behavior of AM60 magnesium alloy 显示文摘 | Wenjuan Liu Fahe Cao Linrong Chang | 2009 | Corrosion Science2009，51，： | 1 |
| 15 | The c-derivative of Boolean functions and its application in fault detection of combinational circuits显示文摘 | WANG Fang YING Shiyan XIAO Linrong | 2014 | Journal of Zhejiang University:Science Edition2014，41，2： | 1 |
| 16 | Asbestos tailings as aggregates for asphalt mixture 显示文摘 | Liu Xiaoming Xu Linrong | 2011 | Journal of Wuhan University of Technology-Materials Science Edition2011，26，： | 1 |
| 17 | The prepa-ration and corrosion behaviors of MAO coating on AZ91Dwith rare earth conversion precursor film 显示文摘 | Jingshun Cai Fahe Cao Linrong Chang | 2011 | AppliedSurface Science2011，257，： | 1 |
| 18 | Effects of typical corn kernel shapes on the forming of repose angle by DEM simulation显示文摘Corn kernel shape is an important feature to improve the accuracy of simulation results,also the repose angle is often used to calibrate model parameters in simulation.In this study,the effects of the corn kernel shapes on the behavior during corn kernels accumulation were investigated in detail.Firstly,the DEM models of three typical shapes of corn kernels were developed.Secondly,the influences of the corn kernel shapes on the process of forming repose angle were investigated,such as corn kernels distance change,energy conversion,and the contact number between corn kernels.Results show that the corn kernel shape has a significant effect on the repose angle formation.The irregular shape of corn kernels limit their rolling when adding the corn kernel length in one or two directions.In addition,the irregular shapes of corn kernels increase the contact number and extend simulation time.Regular shape corn kernels need to be mixed with irregular shape corn kernels to improve their flowability.Finally,observation of the trajectory of corn kernel repose angles indicates that spherical corn kernels contact the bottom plate early,and forming small cone first,then the cone becomes bigger to change the direction of other corn kernels from top to bottom. | Linrong Shi Wuyun Zhao Xiaoping Yang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 1 |
| 19 | JAK3 mediates c-myc gene expression induced by interleukin-2显示文摘C myc gene expression can be rapidly induced by IL 2 through intracellular signal transduction which is triggered by the interaction between IL 2 and its receptor (IL 2R). JAK3 which associates to the intracellular domain of IL2R γ may play a critical role in this process. To reveal the action of JAK3 in c myc induction, a chimeric receptor gene IL2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL 2R α subunit (IL2R α), the transmembrane sequence derived from IL2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 (Δ NJAK3), and then transfected this chimeric gene into mouse fibroblast cell line L929 β which had been transfected with IL2R β gene and stably expressed IL2R β in high level. In the transfectants coexpressing IL2R β and α/γ/Δ NJAK3, the stimulation of IL2 could intensively induce c myc gene expression. Because the whole cytoplasmic domain of IL2R γ which could recruit signaling molecules was replaced by JAK3 and the c myc could be still induced by IL2 in this situation, the results here gave the direct evidence demonstrating that JAK3 plays an important role in c myc gene expression induced by IL2. | Zhu Jinfang Lu Linrong Ji Hongbin Zheng Zhongcheng J. Thèze Liu Xinyuan | 1998 | Chinese Science Bulletin1998，43，4： | 1 |
| 20 | Effect of taro earth element Ce and La on corrosion behavior of AM60 magnesium alloy显示文摘 | Liu Wenjuan Cao Fahe Chang Linrong | 2009 | Corrosion Science2009，51，6： | 1 |
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