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| 1 | Pinning weighted complex networks with heterogeneous delays by a small number of feedback controllers显示文摘Weighted complex dynamical networks with heterogeneous delays in both continuous-time and discrete-time domains are controlled by applying local feedback injections to a small fraction of network nodes. Some generic stability criteria ensuring delay-independent stability are derived for such controlled networks in terms of linear matrix inequalities (LMIs), which guarantee that by placing a small number of feedback controllers on some nodes the whole network can be pinned to some desired homogenous states. In some particular cases, a single controller can achieve the control objective. It is found that stabilization of such pinned networks is completely determined by the dynamics of the individual uncoupled node, the overall coupling strength, the inner-coupling matrix, and the smallest eigenvalue of the coupling and control matrix. Numerical simulations of a weighted network composing of a 3-dimensional nonlinear system are finally given for illustration and verification. | XIANG LinYing LIU ZhongXin CHEN ZengQiang YUAN ZhuZhi | 2008 | Science in China(Series F)2008，51，5： | 8 |
| 2 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 3 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 4 | MICROSTRUCTURE OF INTERFACE BETWEEN HVOF SPRAYED WC-Co COATING AND SPRING STEEL SUBSTRATE显示文摘MICROSTRUCTUREOFINTERFACEBETWEENHVOFSPRAYEDWC-CoCOATINGANDSPRINGSTEELSUBSTRATE￥ShaoBeiling;LiuAnsheng;WangXiaohua;LiYonghong;... | Shao Beiling Liu Ansheng Wang Xiaohua Li Yonghong Zou Linying Wang Jing Zhang Jianguo Shi Changyong Zhou Yiru(General Research institute For Nonferrous Metals,Beijing 100088) | 1996 | 中国有色金属学会会刊:英文版1996，6，4： | 3 |
| 5 | Effects of moxibustion on heat-shock protein 70 expression in the spinal cord and colonic mucosa in a rat model of ulcerative colitis显示文摘Pathological changes in the colon are closely associated with the spinal cord,and innervation of spinal cord can regulate cellular functions.Our previous studies verified that moxibustion protects and restores the colonic mucosa,but the mechanisms of action remain unknown.The present study observed the effects of moxibustion and salicylazosulfapyridine on expression of heat-shock protein 70(HSP70) and its mRNA in the spinal cord and colonic mucosa of ulcerative colitis rats.Results demonstrated that moxibustion and salicylazosulfapyridine increased HSP70 mRNA expression in the spinal cord and colonic mucosa of ulcerative colitis rats.The decreased transcriptional activity of HSP70 in the spinal cord and colonic mucosa might participate in damage to the colonic mucosa in ulcerative colitis rats.Moxibustion exerted protective effects on colonic mucosa by up-regulating HSP70 transcriptional activity in the spinal cord and colonic mucosa. | Li Qi Yin Shi Luyi Wu Jingping Mu Linying Tan Xiaopeng Ma Huirong Liu Shifen Xu Huangan Wu | 2010 | Neural Regeneration Research2010，5，22： | 3 |
| 6 | High-strength porous alumina ceramics prepared from stable wet foams显示文摘Porous ceramics have been widely used in heat insulation,filtration,and as a catalyst carrier.Ceramics with high porosity and high strength are desired;however,this high porosity commonly results in low strength materials.In this study,porous alumina with high porosity and high strength was prepared by a popular direct foaming method based on particle-stabilized wet foam that used ammonium polyacrylate(PAA)and dodecyl trimethyl ammonium chloride(DTAC)as the dispersant and hydrophobic modifier,respectively.The effects of the dispersant and surfactant contents on the rheological properties of alumina slurries,stability of wet foams,and microstructure and mechanical properties of sintered ceramics were investigated.The microstructure of porous ceramics was regulated using wet foams to achieve high strength.For a given PAA content,the wet foams exhibited increasing stability with increasing DTAC content.The most stable wet foam was successfully obtained with 0.40 wt%PAA and 0.02 wt%DTAC.The corresponding porous alumina ceramics had a porosity of 82%,an average grain size of 0.7μm,and a compressive strength of 39 MPa.However,for a given DTAC content,the wet foams had decreasing stability with increasing PAA content.A possible mechanism to explain these results is analyzed. | Linying WANG Liqiong AN Jin ZHAO Shunzo SHIMAI Xiaojian MAO Jian ZHANG Juan LIU Shiwei WANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 3 |
| 7 | Composition and origin of lipid biomarkers in the surface sediments from the southern Challenger Deep, Mariana Trench显示文摘The surface sediments collected from the southern Mariana Trench at water depths between ca.4900 m and 7068 m were studied using lipid biomarker analyses to reveal the origin and distribution of organic matters. For all samples, an unresolved complex mixture(UCM) was present in the hydrocarbon fractions, wherein resistant component tricyclic terpanes were detected but C_(27)-C _(29) regular steranes and hopanes indicative of a higher molecular weight range of petroleum were almost absent.This biomarker distribution patterns suggested that the UCM and tricyclic terpanes may be introduced by contamination of diesel fuels or shipping activities and oil seepage elsewhere. The well-developed faults and strike-slip faults in the Mariana subduction zone may serve as passages for the petroleum hydrocarbons. In addition, the relative high contents of even n-alkanes and low Carbon Preference Indices indicated that the n-alkanes were mainly derived from bacteria or algae. For GDGTs, the predominance of GDGT-0 and crenarchaeol, together with low GDGT-0/Crenarchaeol ratios(ranging from0.86 to 1.64), suggests that the GDGTs in samples from the southern Mariana Trench were mainly derived from planktic Thaumarchaeota. However, the high GDGT-0/crenarchaeol ratio(10.5) in sample BC07 suggests that the GDGTs probably were introduced by methanogens in a more anoxic environment. Furthermore, the n-alkanes C_(19)-C_(22) and the n-fatty acids C_(20:0)-C_(22:0) were depleted in^(13)C by 3‰ compared to n-alkanes C_(16)-C_(18) and the n-fatty acids C_(14:0)-C_(18:0), respectively, which was interpreted to result from the preferential reaction of fatty acid fragments with carbon 'lighter' terminal carboxyl groups during carbon chain elongation from the precursors to products. The abundance of total alkanes, carboxylic acids, alcohols and total lipids were generally increased along the down-going seaward plate, suggesting the lateral organic matter inputs play an important role in organic matter accumulation in hadal trenches. The extremely high contents of biomarkers in sample BC11 were most likely related to trench topography and current dynamics, since the lower steepness caused by graben texture and proximity to the trench axis may result in higher sedimentation rate. This paper, for the first time, showed the biomarker patterns in surface sediments of the Mariana Trench and shed light on biogeochemistry of the hardly reached trench environment. | Hongxiang Guan Linying Chen Min Luo Lihua Liu Shengyi Mao Huangmin Ge Mei Zhang Jiasong Fang Duofu Chen | 2019 | Geoscience Frontiers2019，10，1： | 2 |
| 8 | Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo显示文摘Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic Classification System(BCS) category was determined using equilibrium solubility, intrinsic dissolution rate, and intestinal permeability to evaluate intestinal absorption mechanisms of baicalein in rats in vitro. Physiologically based pharmacokinetic(PBPK) model commercial software GastroPlus~(TM) was used to predict oral absorption of baicalein in vivo.Results: Based on equilibrium solubility, intrinsic dissolution rate, and permeability values of main absorptive segments in the duodenum, jejunum, and ileum, baicalein was classified as a drug with low solubility and high permeability. Intestinal perfusion with venous sampling(IPVS) revealed that baicalein was extensively metabolized in the body, which corresponded to the low bioavailability predicted by the PBPK model. Further, the PBPK model predicted the key indicators of BCS, leading to reclassification as BCS-II. Predicted values of peak plasma concentration of the drug(C_(max)) and area under the curve(AUC)fell within two times of the error of the measured results, highlighting the superior prediction of absorption of baicalein in rats, beagles, and humans. The PBPK model supported in vitro and in vivo evidence and provided excellent prediction for this BCS class II drug.Conclusion: BCS and PBPK are complementary methods that enable comprehensive research of BCS parameters, intestinal absorption rate, metabolism, prediction of human absorption fraction and bioavailability, simulation of PK, and drug absorption in various intestinal segments across species. This combined approach may facilitate a more comprehensive and accurate analysis of the absorption characteristics of active ingredients of Chinese medicine from in vitro and in vivo perspectives. | Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，3： | 2 |
| 9 | EnhancedgenerationofhelperTtypeland2chemokine- sinallergen-inducedasthma 显示文摘 | LIU LINYING JARJOUR NIZAR N BUSSE WILLIAM W | 2004 | American Journal of Res- piratory and Critical Care Medicine2004，169，10： | 1 |
| 10 | Synthesis of Fe 3 O 4 @ZIF-8 magnetic core–shell microspheres and their potential application in a capillary microreactor显示文摘 | Tong Zhang Xiongfu Zhang Xinjuan Yan Linying Kong Guangcai Zhang Haiou Liu Jieshan Qiu King Lun Yeung | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 11 | Measurement of the second virial coefficient of DPPC-and DPPG-liposomes by isothermal titration calorimetry显示文摘 | LinY M Liu D Z Haw H M | 2007 | J Chin Inst Chem Eng2007，38，2： | 1 |
| 12 | Decentralized formation control of mobile agents: A unified framework显示文摘 | Fei Chen Zengqiang Chen Zhongxin Liu Linying Xiang Zhuzhi Yuan | 2008 | Physica A: Statistical Mechanics and its Applications2008，，19： | 1 |
| 13 | Pinning control of complex dynamical networks with heterogeneous delays 显示文摘 | Xiang Linying Chen Zengqiang Liu Zhongxin | 2008 | Computers and Mathematics with Applications2008，56，5： | 1 |
| 14 | Highly Effective Inactivation of Pseudomonas sp HB1 in Water By Atmospheric Pressure Microplasma Jet Array显示文摘 | Xianhui Zhang Dongping Liu Hongzhe Wang Linying Liu Songbai Wang Si-ze Yang | 2012 | Plasma Chemistry and Plasma Processing2012，，： | 1 |
| 15 | Tannin dynamics of propagules and leaves of Kandelia candel and Bruguiera gymnorrhiza in the Jiulong River Estuary,Fujian,China显示文摘 | LinY M Liu J W Xiang P | 2006 | Biogeochemistry2006，78，： | 1 |
| 16 | Delivery systems for theranostics in neurodegenerative diseases显示文摘 | Yan Li Ruiyuan Liu Weihong Ji Yanhui Li Linying Liu Xin Zhang | 2018 | Nano Research2018，11，10： | 1 |
| 17 | Pinning control of complex dynamical networks with heterogene- ous delays显示文摘 | Xiang Linying Chen Zengqiang Liu Zhongxin | 2007 | Computers and Mathematics with Applications2007，379，1： | 1 |
| 18 | BindingDB: a web-accessible database of experimenta//y determined protein-ligand binding a?nities 显示文摘 | Liu T LinY Wen X | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 19 | Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy显示文摘Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments.Here,we utilized single-cell transcriptomic analysis and integrated clinical observations and laboratory examination to dissect the host immune responses and reveal pathological mechanisms in COVID-19-associated pediatric encephalopathy.We found that lymphopenia was a prominent characteristic of immune perturbation in COVID-19 patients with encephalopathy,especially those with acute necrotizing encephalopathy(AE).This was characterized a marked reduction of various lymphocytes(e.g.,CD8^(+)T and CD4^(+)T cells)and significant increases in other inflammatory cells(e.g.,monocytes).Further analysis revealed activation of multiple cell apoptosis pathways(e.g.,granzyme/perforin-,FAS-and TNF-induced apoptosis)may be responsible for lymphopenia.A systemic S100A12 upregulation,primarily from classical monocytes,may have contributed to cytokine storms in patients with AE.A dysregulated type I interferon(IFN)response was observed which may have further exacerbated the S100A12-driven inflammation in patients with AE.In COVID-19 patients with AE,myeloid cells(e.g.,monocytic myeloid-derived suppressor cells)were the likely contributors to immune paralysis.Finally,the immune landscape in COVID-19 patients with encephalopathy,especially for AE,were also characterized by NK and T cells with widespread exhaustion,higher cytotoxic scores and inflammatory response as well as a dysregulated B cell-mediated humoral immune response.Taken together,this comprehensive data provides a detailed resource for elucidating immunopathogenesis and will aid development of effective COVID-19-associated pediatric encephalopathy treatments,especially for those with AE. | Yi Wang Laurence Don Wai Luu Shuang Liu Xiong Zhu Siyuan Huang Fang Li Xiaolan Huang Linying Guo Jin Zhang Haiyan Ge Yuanyuan Sun Yi Hui Yanning Qu Huicong Wang Xiaoxia Wang Weilan Na Juan Zhou Dong Qu Jun Tai | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 20 | Comparison between pinning control of different chaotic complex dynamical networks显示文摘The stabilization properties of various typical complex dynamical networks composed of chaotic nodes are theoretically investigated and numerically simulated in detail. Some local stability properties of such pinned networks are derived and the valid stability regions are estimated based on eigenvalue analysis. Numerical simulations of such networks are given to explain why significantly less local controllers are needed by the specifically pinning scheme, which pins the most highly connected nodes in scale-free networks, than that required by the randomly pinning scheme. Also, it is explained why there is no significant difference between the two schemes for controlling random-graph networks and small-world networks. | Linying XIANG Zhongxin LIU Zengqiang CHEN Fei CHEN Ge GUO Zhuzhi YUAN | 2008 | 控制理论与应用(英文版)2008，6，1： | 0 |
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