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| 1 | Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2αsignaling pathway in IPEC-J2 cells显示文摘Background:Rotavirus(RV)is a major pathogen that causes severe gastroenteritis in infants and young animals.Endoplasmic reticulum(ER)stress and subsequent apoptosis play pivotal role in virus infection.However,the protective mechanisms of intestinal damage caused by RV are poorly defined,especially the molecular pathways related to enterocytes apoptosis.Thus,the aim of this study was to investigate the protective effect and mechanism of sodium butyrate(SB)on RV-induced apoptosis of IPEC-J2 cells.Results:The RV infection led to significant cell apoptosis,increased the expression levels of ER stress(ERS)markers,phosphorylated protein kinase-like ER kinase(PERK),eukaryotic initiation factor 2 alpha(eIF2α),caspase9,and caspase3.Blocking PERK pathway using specific inhibitor GSK subsequently reversed RV-induced cell apoptosis.The SB treatment significantly inhibited RV-induced ERS by decreasing the expression of glucose regulated protein 78(GRP78),PERK,and eIF2α.In addition,SB treatment restrained the ERS-mediated apoptotic pathway,as indicated by downregulation of C/EBP homologous protein(CHOP)mRNA level,as well as decreased cleaved caspase9 and caspase3 protein levels.Furthermore,siRNA-induced GPR109a knockdown significantly suppressed the protective effect of SB on RV-induced cell apoptosis.Conclusions:These results indicate that SB exerts protective effects against RV-induced cell apoptosis through inhibiting ERS mediated apoptosis by regulating PERK-eIF2αsignaling pathway via GPR109a,which provide new ideas for the prevention and control of RV. | Ye Zhao Ningming Hu Qin Jiang Li Zhu Ming Zhang Jun Jiang Manyi Xiong Mingxian Yang Jiandong Yang Linyuan Shen Shunhua Zhang Lili Niu Lei Chen Daiwen Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 2 |
| 2 | Magnetic Hardening of Rapidly Quenched Co-M-Zr(M=B,Fe)Alloys显示文摘Effects of the quenching rate and annealing temperature on hard magnetic properties of rapidly quenched Co_(84-x)B_(x)Zr_(16)and Co_(82-x)Fe_(x)Zr_(18)alloys were studied.The B-or Fe-content dependence of room temperature coercivity H_(c),remanence B_(r) and maximum energy product(BH)_(max) are obtained.The H_(c) is suggested to originate from the microstructure with the optimal grain size. | SHEN Baogen YANG Linyuan CAO Lei GUO Huiqun | 1993 | Chinese Physics Letters1993，10，3： | 1 |
| 3 | Comparison of the meat quality, post-mortem muscle energy metabolism, and the expression of glycogen synthesis-related genes in three pig crossbreeds显示文摘 | LEI Huaigang SHEN Linyuan ZHANG Shunhua | 2014 | Animal Production Science2014，55，4： | 1 |
| 4 | Magnetic Proper ties and Crystallization of Amorphous Fe-Nd-B Alloys at Cons taut B Concentration显示文摘Ma.gnetiza.tion,Curie teiiiperti.ture mid crystallization temperature measurements for amorphous(Fe_(1-x)Nd_(x))_(100-y)B_(y) iilloys with y=6,18.5 and 25 have been made.Spon-taneous magnetization shows a monotonic decrease with x,and the noncollinear spin structures have been proposed to expluin the observed results.The composition dependence of Curie tenipertitiire is exphtined by the average niolecular-field model.The substitu lion of siim.ll N<1 for Fc is found to have a strong enha.nccinent of the theriiml stability in amorphous Fe-Nd-B alloys. | SHEN Baogen YANG Linyuan ZHAO Jiangao GUO Huiqun | 1993 | Chinese Physics Letters1993，10，10： | 0 |
| 5 | Heat management technology for solid-state high voltage and high repetitive pulse generators:Towards better effects and reliability显示文摘Solid-state high voltage high repetitive pulse generators have a broad prospect in various applications.The high power and high-frequency operation of the pulse generator suffer from the massive heat dissipation problem,which limits the improvement of the output parameters and even affects the lifetime.This article focuses on heat management technology for high voltage high repetitive pulse generators.Firstly,the typical circuit topology of the high repetitive pulse generators was summarised.From the perspective of different application requirements,the demands of the heat management design were concluded.Moreover,the heat generation characteristics and difficulties of solid-state high voltage high repetitive pulse generators were analysed.Then,the different stateof-art cooling techniques were reviewed,and their applicability and limitations for the high voltage high repetitive generators were discussed.Finally,a flow chart for heat management design was given. | Yanan Wang Linyuan Ren Zihao Yang Saikang Shen Zichen Deng Qi Yuan Weidong Ding Zhenjie Ding | 2024 | High Voltage2024，9，1： | 0 |
| 6 | CRYSTALLIZATION OF AMORPHOUS Fe_(62)Co_(15.5)Nd_(4)B_(18.5) ALLOY AND ITS INFLUENCE ON HARD MAGNETIC PROPERTIES显示文摘Magnetic properties and crystallization of amorphous Fe_(62)Co_(15.5)Nd_(4)B_(18.5) alloy are studied.The Curie temperature of the present sample is 127K higher than that of amorphous Fe_(77.5)Nd_(4)B_(18.5) alloy,but their crystallization temperature is compatible with each other.A coercive field of 2.34kOe,a remanence of 12.3kG and an energy product of 11.6MGOe are obtained at room temperature in the Fe_(62)Co_(15.5)Nd_(4)B_(18.5) alloy annealed at 650°C.The 15.5at.%-Co substitution for Fe results in an increase of about 1l0K in Tc of 2:14:1 phase. | SHEN Baogen YANG Linyuan ZHANG Junxian WO Feng NING Taishan ZHAO Jiangao GUO Huiqun ZHAN Wenshan | 1990 | Chinese Physics Letters1990，7，9： | 0 |
| 7 | MAGNETIC PROPERTIES AND CRYSTALLIZATION OF RAPIDLY QUENCHED(Fe_(1-x)Ga_x)_(77.5)Nd_4B_(18.5) ALLOYS显示文摘The Curie temperature increases but crystallization temperature decreases with the in-crease of Ga content,x,of amorphous(Fe1-xGax)77.5Nd4B18.5 alloys.The averagemagnetic moment of Fe atoms is almost a constant.By X-ray diffraction and ther-momagnetic measurements,the crystalline phases of the alloys,an unknown phase andα-(Fe,Ga)besides Fe3 B as major one,were identified.The relationship between roomtemperature coercive field and Ga.content was also studied. | YANG Hongying SHEN Baogen YANG Linyuan GUO Huiqun Laboratory of Magnetics,Institute of Physics,Academia Sinica,Beijing,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，11： | 0 |
| 8 | A NEW PERMANENT MAGNETIC MATERIALS CRYSTALLIZED FROM AMORPHOUS Co_(84-x)BxZr_(16) ALLOYS显示文摘The crystallization of amorphous Co_(84-x)BxZr_(16) alloys and the influence of heat treatment on its hard magnetic properties are studied.The dependence of B-content on crystallization temperature of the samples is determined from differential scanning calorimetric(DSC)traces.The intrinsic coercivities iHc are found to increase with increasing annealing temperature and go through a mazimum then to lower values.A coercivity of 2.7kOe and an energy product of 4.0MGOe are obtained at room temperature in Co_(82)B_(2)Zr_(16) alloy annealed at 660°C for a short time.These alloys would be expected as an applicable mate rid for permanent magnet. | SHEN Baogen GUO Huiqun YANG Linyuan ZHAO Jian gao | 1990 | Chinese Physics Letters1990，7，8： | 0 |
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