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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Modified VP22 localizes to the celt nucleus during synchronized herpes simplex virus type 1 infection 显示文摘 | Lisa E P John A B | 1999 | J Virot1999，73，8： | 1 |
| 3 | Clearance of hepatitis B eantigen in patients with chronic hepatitis B and genotypes A,B,C,D and F显示文摘 | Stephen E L Josephine P S Lisa R B | 2007 | Gastroenterology2007，133，5： | 1 |
| 4 | Chromosomal end-to- end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit 显示文摘 | Rebuzzini P Lisa A Giulotto E | 2004 | Cancer Lett2004，203，1： | 1 |
| 5 | Assembly of infectious herpes simplex virus Type 1 virions in the absence of full-length VP22 显示文摘 | Lisa E P John B | 2000 | J Virol2000，74，10： | 1 |
| 6 | Open Diaphyseal Long Bone Fractures: A Reduction Method Using Devitalized or Extruded Osseous Fragments显示文摘 | David P Barei Lisa A Taitsman Daphne Beingessner Robert P Dunbar Sean E Nork | 2007 | Journal of Orthopaedic Trauma2007，，： | 1 |
| 7 | An atypical deletion of the Williams-Beuren syndrome interval implicates genes associated with defective visuospatial processing and autism显示文摘 | Lisa E Aaron P Sherly P | 2007 | J Med Genet2007，44，2： | 1 |
| 8 | Compaction of DNA by Gemini Surfactants: Effects of Surfactant Architecture显示文摘 | Lisa K Marcel C P Van E | 2002 | Journal of Colloid and Interface Science2002，252，： | 1 |
| 9 | Effects of oil sand process-affected waters and napthenic acids on yellow perch ( Perea flavescens ) andJapanese medaka ( Orizias latipes) embryonic development显示文摘 | Lisa E P Mackinnon M Meer TV | 2007 | Chemos ph ere2007，67，11： | 1 |
| 10 | Overexpression of a Blueberry-derived CBF Gene Enhances Cold Tolerance in a Southern Highbush Blueberry Cultivar 显示文摘 | Aaron E W Lisa J R James J P | 2012 | Mol Breeding2012，，30： | 1 |
| 11 | coli expression vectors for laboratory scale and high throughput soluble protein production显示文摘 | Lisa D Cabrita Weiwen Dai Stephen P Bottomley:A family of E | 2006 | BMC biotechnology2006，6，： | 1 |
| 12 | Shortening Osteotomy and Compression Plating for Atrophic Humeral Nonunions: Surgical Technique显示文摘 | Michael L Brennan Lisa A Taitsman David P Barei Eric Puttler Sean E Nork | 2008 | Journal of Orthopaedic Trauma2008，，9： | 1 |
| 13 | Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D,and F显示文摘 | Stephen E L Josephine P S Lisa R B | 2007 | Gastroenterology2007，133，5： | 1 |
| 14 | Red cell distribution width in anemic patients undergoing transcatheter aortic valve implantation显示文摘AIM: To determine the impact of red blood cell distribution width on outcome in anemic patients undergoing transcatheter aortic valve implantation(TAVI).METHODS: In a retrospective single center cohort study we determined the impact of baseline red cell distribution width(RDW) and anemia on outcome in 376 patients with aortic stenosis undergoing TAVI. All patients were discussed in the institutional heart team and declined for surgical aortic valve replacement due to high operative risk. Collected data included patient characteristics, imaging findings, periprocedural in hospital data, laboratory results and follow up data. Blood samples for hematology and biochemistry analysis were taken from every patient before and at fixed intervals up to 72 h after TAVI including blood count and creatinine. Descriptive statistics were used for patient's characteristics. KaplanMeier survival curves were used for time to event outcomes. A recursive partitioning regression and classification was used to investigate the association between potential risk factors and outcome variables.RESULTS: Mean age in our study population was 81 ± 6.1 years. Anemia was prevalent in 63.6%(n = 239) of our patients. Age and creatinine were identified as risk factors for anemia. In our study population, anemia per se did influence 30-d mortality but did not predict longterm mortality. In contrast, a RDW > 14% showed to be highly predictable for a reduced short- and longterm survival in patients with aortic valve disease after TAVI procedure.CONCLUSION: Age and kidney function determine the degree of anemia. The anisocytosis of red blood cells in anemic patients supplements prognostic information in addition to that derived from the WHO-based definition of anemia. | Katharina Hellhammer Tobias Zeus Pablo E Verde Verena Veulemanns Lisa Kahlstadt Georg Wolff Ralf Erkens Ralf Westenfeld Eliano P Navarese Marc W Merx Tienush Rassaf Malte Kelm | 2016 | World Journal of Cardiology2016，8，2： | 0 |
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