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| 1 | Endoscopic ultrasound-guided treatments: Are we getting evidence based- a systematic review显示文摘The continued need to develop less invasive alternatives to surgical and radiologic interventions has driven the development of endoscopic ultrasound(EUS)-guided treatments.These include EUS-guided drainage of pancreatic fluid collections,EUS-guided necrosectomy,EUS-guided cholangiography and biliary drainage,EUSguided pancreatography and pancreatic duct drainage,EUS-guided gallbladder drainage,EUS-guided drainage of abdominal and pelvic fluid collections,EUS-guided celiac plexus block and celiac plexus neurolysis,EUSguided pancreatic cyst ablation,EUS-guided vascular interventions,EUS-guided delivery of antitumoral agents and EUS-guided fiducial placement and brachytherapy.However these procedures are technically challenging and require expertise in both EUS and interventional endoscopy,such as endoscopic retrograde cholangiopancreatography and gastrointestinal stenting.We undertook a systematic review to record the entire body of literature accumulated over the past 2decades on EUS-guided interventions with the objective of performing a critical appraisal of published articles,based on the classification of studies according to levels of evidence,in order to assess the scientific progress made in this field. | Carlo Fabbri Carmelo Luigiano Andrea Lisotti Vincenzo Cennamo Clara Virgilio Giancarlo Caletti Pietro Fusaroli | 2014 | World Journal of Gastroenterology2014，20，26： | 18 |
| 2 | Proton pump inhibitors in cirrhosis:Tradition or evidence based practice?显示文摘Proton Pump Inhibitors (PPI) are very effective in inhibiting acid secretion and are extensively used in many acid related diseases. They are also often used in patients with cirrhosis sometimes in the absence of a specific acid related disease, with the aim of preventing peptic complications in patients with variceal or hypertensive gastropathic bleeding receiving multidrug treatment. Contradicting reports support their use in cirrhosis and evidence of their efficacy in this condition is poor. Moreover there are convincing papers suggesting that acid secretion is reduced in patients with liver cirrhosis. With regard to Helicobacter pylori (H pylori) infection, its prevalence in patients with cirrhosis is largely variable among different studies, and it seems that H pylori eradication does not prevent gastro-duodenal ulcer formation and bleeding. With regard to the prevention and treatment of oesophageal complications after banding or sclerotherapy of oesophageal varices, there is little evidence for a protective role of PPI. Moreover, due to liver metabolism of PPI, the dose of most available PPIs should be reduced in cirrhotics. In conclusion, the use of this class of drugs seems more habit related than evidence- based eventually leading to an increase in health costs. | Francesca Lodato Francesco Azzaroli Maria Di Girolamo Valentina Feletti Paolo Cecinato Andrea Lisotti Davide Festi Enrico Roda Giuseppe Mazzella | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 3 | Role of endoscopy in the conservative management of biliary complications after deceased donor liver transplantation显示文摘The clinical outcome of patients receiving liver trans-plantation could be significantly affected by biliary complications, including strictures, leaks, stones and bilomas; early diagnosis and treatment of these con-ditions lead to markedly reduction in morbidity and mortality. Therapeutic gold standard is represented by conservative approaches, both endoscopic and percutaneous, based on the type of biliary reconstruction, the local availability of the procedures and specific expertise. In patients with previous transplantation, the difficult biliary access and the possible presence of concomitant complications(mainly strictures) further restrict the efficacy of the endoscopic and percutaneous treatments; on the other hand, surgery should generally be avoided because of the even increased morbidity and mortality due to technical and clinical issues. Here we review the most common biliary complications occurring after liver transplantation and discuss available treatment options including future perspectives such as endoscopic ultrasound-guided biliary access in patients with Roux-en-Y choledocho-jejunostomy or extracorporeal shock wave lithotripsy for difficult stones. | Andrea Lisotti Pietro Fusaroli Giancarlo Caletti | 2015 | World Journal of Hepatology2015，7，30： | 4 |
| 4 | 内镜超声治疗及其系统回顾显示文摘当代减少外科手术治疗和介入辐射的理念有力地促进了目前内镜超声治疗手段的发展水平。内镜超声已经应用于胰腺积液引流,坏死灶切除,胆管造影及引流,胰管造影及引流,胆囊引流,腹腔及盆腔引流,腹腔丛阻滞及消融,囊肿切除,血管介入,抗肿瘤药物导入,校准放置放疗及抵近放射治疗等领域。然而该技术对操作要求较高,操作人员必须同时精通内镜及内镜介入操作,如内镜下逆行胰胆管造影术(ERCP)及胃肠道支架放置等技术。本文着眼于近20年内发表的所有相关文献进行系统回顾,在循证医学的基础上对现行发表文章进行相对客观的评价,力求推动该领域内的进一步发展。 | 龚雪屹 汪谦 Fabbri C Luigiano C Lisotti A | 2014 | 中华普通外科学文献(电子版)2014，8，6： | 3 |
| 5 | Colonoscopy-related colonic ischemia显示文摘Colonoscopy is a risk factor for colon ischemia.The colon is susceptible to ischemia due to its minor blood flow compared to other abdominal organs;the etiology of colon ischemia after colonoscopy is multifactorial.The causative mechanisms include splanchnic circulation impairment,bowel preparation,drugs used for sedation,bowel wall ischemia due to insufflation/barotrauma,and introduction of the endoscope.Gastroenterologists must be aware of this condition and its risk factors for risk minimization,early diagnosis,and proper treatment. | Sinan Sadalla Andrea Lisotti Lorenzo Fuccio Pietro Fusaroli | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 6 | Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis显示文摘 | Andrea Lisotti Francesco Azzaroli Federica Buonfiglioli Marco Montagnani Paolo Cecinato Laura Turco Claudio Calvanese Patrizia Simoni Massimo Guardigli Rosario Arena Alessandro Cucchetti Antonio Colecchia Davide Festi Rita Golfieri Giuseppe Mazzella | 2014 | Hepatology2014，，2： | 2 |
| 7 | Severe immune thrombocytopenia after peg-interferonalpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature显示文摘Mild to moderate autoimmune thrombocytopenia(AITP) is a common finding in patients receiving interferonbased antiviral treatment, due to bone marrow suppression. Here we report the case of a patient with chronic genotype 1b hepatitis C virus(HCV) infection treated with pegylated-interferon alpha-2a, ribavirin and telaprevir for 24 wk; the patient developed severe AITP three weeks after treatment withdrawal. We performed a systematic literature search in order to review all published cases of AITP related to HCV antiviral treatment. To our knowledge, this is the second case of AITP observed after antiviral treatment withdrawal. In most published cases AITP occurred during treatment; in fact, among 24 cases of AITP related to interferonbased antiviral treatment, only one occurred after discontinuation. Early diagnosis of AITP is a key factor in order to achieve an early interferon discontinuation; in the era of new direct antiviral agents those patients have to be considered for interferon-free treatment regimens. Prompt prescription of immuno-suppressant treatment(i.e., corticosteroids, immunoglobulin infusion and even rituximab for unresponsive cases) leads to favourable prognosis in most of cases. Physicians using interferonbased treatments should be aware that AITP can occur both during and after treatment, specially in the new era of interferon-free antiviral treatment. Finally, in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but alsoafter discontinuation. | Rosario Arena Paolo Cecinato Andrea Lisotti Federica Buonfiglioli Claudio Calvanese Giuseppe Grande Marco Montagnani Francesco Azzaroli Giuseppe Mazzella | 2015 | World Journal of Hepatology2015，7，12： | 2 |
| 8 | Correlation between Indocyanine green retention test and esophageal varices among patients with hepatocellular carcinoma显示文摘 | Andrea Lisotti Francesco Azzaroli Marco Montagnani Alberto Porro Giuseppe Mazzella | 2014 | Journal of Gastroenterology2014，，5： | 1 |
| 9 | Indocyanine green retention test as a noninvasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis显示文摘 | Lisotti A Azzaroli F Buonfiglioli F | 2014 | Hepatology2014，59，2： | 1 |
| 10 | Spleen stiffness measurement can predict clinical complications in compensated HCV-related cirrhosis: a prospective study显示文摘 | Antonio Colecchia Agostino Colli Giovanni Casazza Daniele Mandolesi Ramona Schiumerini Letizia Bacchi Reggiani Giovanni Marasco Martina Taddia Andrea Lisotti Giuseppe Mazzella Anna Rita Di Biase Rita Golfieri Massimo Pinzani Davide Festi | 2014 | Journal of Hepatology2014，，： | 1 |
| 11 | The pharmacological management of intrahepatic cholestasis of pregnancy 显示文摘 | Azzaroli F Turco L Lisotti A | 2011 | Curr Clin Pharmacol2011，6，1： | 1 |
| 12 | Indocyanine green retention test as a non-invasive marker of portal hypertension and esophageal varices in compensated liver cirrhosis 显示文摘 | Lisotti A Azzaroli F Buonfiglioli F | 2014 | Hepatology2014，59，2： | 1 |
| 13 | Conservative management of malignant gastric outlet obstruction syndrome-evidence based evaluation of endoscopic ultrasoundguided gastroentero-anastomosis显示文摘Gastric outlet obstruction(GOO)is a clinical syndrome characterized by postprandial vomiting,abdominal pain,bloating and,in advanced cases,by weight loss secondary to inadequate oral intake.This clinical entity may be caused by mechanical obstruction,either benign or malignant,or by motility disorders.In this review we will focus on malignant GOO and on its endoscopic ultrasound(EUS)-guided palliative treatment.The most frequent malignant causes of this syndrome are gastric and locally advanced pancreatic carcinomas;other causes include duodenal or ampullary neoplasms,gastric lymphomas,retroperitoneal lymphadenopathies and,more infrequently,gallbladder and bile duct cancers.Surgery represents the treatment of choice when radical and curative resection is potentially feasible;if the malignant cause is not likely to be completely resected,palliative treatments should be proposed.Palliative treatments for malignant GOO are primarily based on surgical gastro-jejunostomy and endoscopic placement of an enteral self-expanding metal stent.Both treatments are effective;however,endoscopic stent placement is less invasive and it is associated with good short-term results,while surgery provides longer-lasting effects with a lower frequency of reintervention.In the last few years,EUS-guided gastroenterostomy(GE)has been proposed as palliative treatment for malignant GOO.This novel technique consists of the creation of an anastomosis between the gastric lumen and a small bowel loop distal to the malignant obstruction,through the deployment of a lumen-apposing metal stent under EUS-view.EUS-GE has the advantage of being as minimally invasive as enteral stent placement,and of guaranteeing long-term results similar to those of surgery. | Anna Cominardi Giacomo Tamanini Nicole Brighi Pietro Fusaroli Andrea Lisotti | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 1 |
| 14 | High dose lamivudine in HBV-related cirrhotic patients with unsatisfactory response after adefovir add on 显示文摘 | Montagnani M Giandinoto M Lisotti A | 2012 | Dig Dis Sci2012，57，2： | 1 |
| 15 | 电刀辅助切除(KAP)治疗小直肠神经内分泌瘤显示文摘Rectal neuroendocrine neoplasia(rNEN)are usually small(<10mm),well-differentiated(G1/2)lesions arising from the interface between mucosal and submucosal layers;therefore,polypectomy and standard endoscopic mucosal resection(EMR)techniques are usually not curative due to the presence of neoplastic cells on the resection margin,leading to possible tumor recurrence[1].Ligation-assisted EMR and endoscopic submucosal dissection(ESD)have been proposed as treatment of choice in case of lesions<10mm without muscolaris propria involvement[1-3].However,in real practice,most of these lesions undergo standard EMR and are then refereed to tertiary centers in case of incomplete resections[2,3].Pagano et al.[4]recently demonstrated that,in those cases,ESD was indicated for lesions>3mm because of the risk of residual neoplasia. | Andrea Lisotti Sinan Sadalla Anna Cominardi Nicole Brighi Pietro Fusaroli | 2020 | Gastroenterology Report2020，8，6： | 1 |
| 16 | Long-term leukocyte natural α-interferon and ribavirin treatment in hepatitis C virus recurrence after liver transplantation显示文摘AIM:To evaluate the effect of long-term treatment with leukocyte natural-interferon(ln-α-IFN)plus ribavirin(RBV).METHODS:Forty-six patients with hepatitis C virus(HCV)recurrence received 3 MU three times a week of ln-α-IFN plus RBV for 1 mo;then,patients with good tolerability(n=30)were switched to daily IFN administration,while the remaining were treated with the same schedule.Patients have been treated for 12 mo after viral clearance while non-responders(NR)entered in the longterm treatment group.Liver biopsies were planned at baseline,1 year after sustained virological response(SVR)and at 36 mo after start of therapy in NR.MedCalc software package was used for statistical analysis.RESULTS:About 16.7%of genotype 1-4 and 70%of genotype 2-3 patients achieved SVR.Nine patients withdrew therapy because of non-tolerance or noncompliance.A significant improvement in serum biochemistry and histological activity was observed in all SVR patients and long-term treated;100%of patients with SVR achieved a histological response(fibrosis stabilization or improvement)with a significant reduction in mean staging value(from 2.1 to 1.0;P=0.0031);histological response was observed in 84%of long-term treated patients compared to 57%of drop-out.Six patients died during the entire study period(follow-up 40.6±7.7 mo);of them,5 presented with severe HCV recurrence on enrollment.Diabetes(OR=0.38,95%CI:0.08-0.59,P=0.01),leukopenia(OR=0.54,95%CI:0.03-0.57,P=0.03)and severe HCV recurrence(OR=0.51,95%CI:0.25-0.69,P=0.0003)were variables associated to survival.Long-term treatment was well tolerated;no patients developed rejection or autoimmune disease.CONCLUSION:Long-term treatment improves histology in SVR patients and slows disease progression also in NR,leading to a reduction in liver decompensation,graft failure and liver-related death. | Mariarosa Tamè Federica Buonfiglioli Massimo Del Gaudio Andrea Lisotti Paolo Cecinato Antonio Colecchia Francesco Azzaroli Antonietta D’Errico Rosario Arena Claudio Calvanese Chiara Quarneti Giorgio Ballardini Antonio Daniele Pinna Giuseppe Mazzella | 2013 | World Journal of Gastroenterology2013，19，32： | 0 |
| 17 | Single-use duodenoscopes for the prevention of endoscopic retrograde cholangiopancreatography -related cross-infection – from bench studies to clinical evidence显示文摘BACKGROUND Several strategies have been implemented to reduce or abolish the life-threatening risk of endoscopic retrograde cholangiopancreatography(ERCP)-related multidrug-resistant infections due to duodenoscopes contaminations;among those strategies,serial microbiologic tests,thorough reprocessing schedules,and use of removable scope cap have been adopted,but the potential cross-infection risk was not eliminated.AIM To review available evidence in the field of single-use duodenoscopes(SUD)use for ERCP.METHODS An overview on ongoing clinical studies was also performed to delineate which data will become available in the next future.RESULTS One bench comparative study and four clinical trials performed with EXALT model-D(Boston Scientific Corp.,United States)have been identified.Of them,one is a randomized controlled trial,while the other three studies are prospective single-arm,cross-over studies.Pooled technical success rate(4 studies,368 patients)was 92.9%[95%confidence interval(CI):89.9-95.5;I2:11.8%].Pooled serious adverse event(4 studies,381 patients)rate was 5.9%[3.7%-8.5%;I2:0.0%].CONCLUSION Although few clinical trials are available,evidence is concordant in identifying an absolute feasibility and safety and feasibility for SUD use for ERCP.The expertise and quality of evidence in this field are going to be improved by further large clinical trials;data on cost-effectiveness and environmental impact will be needed for a worldwide spread of SUD use for ERCP. | Andrea Lisotti Pietro Fusaroli Bertrand Napoleon Anna Cominardi Rocco Maurizio Zagari | 2022 | World Journal of Methodology2022，12，3： | 0 |
| 18 | 一种特制的黏稠溶液用于黏膜下注射可确保快速安全地对巨大(8 cm)盲肠侧向生长型肿瘤行内镜黏膜切除术显示文摘Endoscopic mucosal resection(EMR)is the technique of choice for large colonic laterally spreading tumors(LSTs)[1].The use of a dye-containing fluid solution for submucosal injection is necessary for a better depiction of polyp margins,deep wall layers,and possible residual tissue[2].In recent years,dedicated viscous solutions have been registered for gastrointestinal(GI)endoscopy together with other routinely used non-dedicated viscous solutions,such as hyaluronic acid or Gelofusine,Eleview(Aries Pharmaceutical,CA,USA). | Andrea Lisotti Pietro Fusaroli | 2021 | Gastroenterology Report2021，9，5： | 0 |
| 19 | Diagnostic performance of endoscopic ultrasound-guided tissue acquisition of splenic lesions:systematic review with pooled analysis显示文摘Background Focal splenic lesions are usually incidentally discovered on radiological assessments.Although percutaneous tissue acquisition(TA)under trans-abdominal ultrasound guidance is a well-established technique for obtaining cyto-histological diagnosis of focal splenic lesions,endoscopic ultrasound(EUS)-guided TA has been described in several studies,reporting different safety and outcomes.The aimwas to assess the pooled safety,adequacy,and accuracy of EUS-TA of splenic lesions.Methods A comprehensive review of available evidence was conducted at the end of November 2021.All studies including more than five patients and reporting about the safety,adequacy,and accuracy of EUS-TA of the spleen were included.Results Six studies(62 patients)were identified;all studies have been conducted using fine-needle aspiration(FNA)needles.Pooled specimen adequacy and accuracy of EUS-TA for spleen characterization were 92.8%[95%confidence interval(CI),86.3%–99.3%]and 88.2%(95%CI,79.3%–97.1%),respectively.The pooled incidence of adverse events(six studies,62 patients)was 4.7%(95%CI,0.4%–9.7%).Conclusion EUS-FNA of the spleen is a safe technique with high diagnostic adequacy and accuracy.The EUS-guided approach could be considered a valid alternative to the percutaneous approach for spleen TA. | Andrea Lisotti Stefano Francesco Crino` Benedetto Mangiavillano Anna Cominardi Andrew Ofosu Nicole Brighi Flavio Metelli Rocco Maurizio Zagari Antonio Facciorusso Pietro Fusaroli | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 20 | Endoscopic ultrasound fine-needle biopsy vs fine-needle aspiration for lymph nodes tissue acquisition:a systematic review and meta-analysis显示文摘Background:Endoscopic ultrasound(EUS)-guided tissue acquisition represents the choice of methods for suspected lymph nodes(LNs)located next to the gastrointestinal tract.This study aimed to compare the pooled diagnostic performance of EUS-guided fine-needle biopsy(EUS-FNB)and fine-needle aspiration(EUS-FNA)for LNs sampling.Methods:We searched PubMed/MedLine and Embase databases through August 2021.Primary outcome was diagnostic accuracy;secondary outcomes were sensitivity,specificity,sample adequacy,optimal histological core procurement,number of passes,and adverse events.We performed a pairwise meta-analysis using a random-effects model.The results are presented as odds ratio(OR)or mean difference along with 95%confidence interval(CI).Results:We identified nine studies(1,276 patients)in this meta-analysis.Among these patients,66.4%were male;the median age was 67 years.Diagnostic accuracy was not significantly different between the two approaches(OR,1.31;95%CI,0.81–2.10;P=0.270).The accuracy of EUS-FNB was significantly higher when being performed with newer end-cutting needles(OR,1.87;95%CI,1.17–3.00;P=0.009)and in abdominal LNs(OR,2.48;95%CI,1.52–4.05;P<0.001)than that of EUSFNA.No difference in terms of sample adequacy was observed between the two approaches(OR,1.40;95%CI,0.46–4.26;P=0.550);however,histological core procurement and diagnostic sensitivity with EUS-FNB were significantly higher than those with EUS-FNA(OR,6.15;95%CI,1.51–25.07;P=0.010 and OR,1.87;95%CI,1.27–2.74,P=0.001).The number of needle passes needed was significantly lower in the EUS-FNB group than in the EUS-FNA group(mean difference,-0.54;95%CI,-0.97 to -0.12;P=0.010).Conclusions EUS-FNA and EUS-FNB perform similarly in LN sampling;however,FNB performed with end-cutting needles outperformed FNA in terms of diagnostic accuracy. | Antonio Facciorusso Stefano Francesco Crino Paraskevas Gkolfakis Daryl Ramai Andrea Lisotti Ioannis S Papanikolaou Benedetto Mangiavillano Ilaria Tarantino Andrea Anderloni Carlo Fabbri Konstantinos Triantafyllou Pietro Fusaroli | 2022 | Gastroenterology Report2022，10，1： | 0 |
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