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	题名	作者	年代	出处	被引量
1	T-cell ageing in end-stage renal disease patients:Assessment and clinical relevance显示文摘End-stage renal disease(ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment.This is likely to be caused by the uremia-associated pro-inflammatory milieu,created by loss of renal function.Therefore,ESRD patients are highly susceptible for infections,have an increased risk for virus-associated cancers,respond poorly to vaccination and have an increased risk for atherosclerotic diseases.Three ageing parameters can be used to assess an immunological T-cell age.First,thymic output can be determined by assessing the T-cell receptor excision circlescontent together with CD31 expression within the naive T cells.Second,the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing.Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age.After kidney transplantation(KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished.This might be explained by epigenetic modifications at hematopoietic stem cells level.Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression.	Ruud WJ Meijers Michiel GH Betjes Carla C Baan Nicolle HR Litjens	2014	World Journal of Nephrology2014，3，4：	2
2	C-type lectin DCSIGN modulates Toll-like receptor signaling via Raf-1 kinase-depend- ent acetylation of transcriPtion factor NF-kappaB显示文摘	Gringhuis S I den-Dunnen J Litjens M	2007	Immunity2007，26，5：	1
3	Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori 显示文摘	Gringhuis SI den Dunnen J Litjens M	2009	Nat Immuuol2009，10，10：	1
4	Malate plays a central role in plant nutrition显示文摘	SCHUZE J TESFAYE M LITJENS R H	2002	Plant and Soil2002，247，：	1
5	Chronic Kidney Disease and premature age- ing of the adaptive immune response 显示文摘	Betjes MG Litjens NH	2015	Current Urology Reports2015，16，1：	1
6	Current insights into the formation and breakdown of hemidesmosomes 显示文摘	Litjens SH de Pereda JM Sonnenberg A	2006	Trends Cell Biol2006，16，37：	1
7	Serine phos phorylation of the integrin beta4 subunit is necessary for epi- dermal growth factor receptor induced hemidesmosome dis- ruption 显示文摘	Wilhelmsen K Litjens SH Kuikman I	2007	Mol Biol Cell2007，18，9：	1
8	C-Type Lectin DC-SIGN modulates Toll like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kB 显示文摘	Gringhuis SI den Dunnen J Litjens M	2007	Immunity2007，26，5：	1
9	IFN-γ activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigene-specific T cells显示文摘	Kelly MN Kenneth BG Litjen T	1997	J Immunol1997，158，：	1
10	Time course of atrial fibrillation-induced cellular structural remodeling in atria of the goat 显示文摘	Ausma J Litjens N Lenders MH	2001	J Mol Cell Cardio12001，33，12：	1
11	Multiple functions of the Integrin a6β4 in epidermal homeostasis and tumorigenesis显示文摘	Wilhelmsen K Litjens SH Sonnenberg A		0，，8：	1
12	Dectin-I di- rects T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk显示文摘	Gringhuis SI den Dunnen J Litjens M	2009	Nat Im- munol2009，10，2：	1
13	C-type lectin DC-SIGN modulates via Raf-1 kinase-dependent Toll-like receptor signaling acetylation of transcription factor NF-kappaB显示文摘	Gringhuis S I Dendunnen J Litjens M	2007	Immunity2007，26，5：	1
14	Carbohydrate-specificsignaling through the DC-SIGN signalosome tailors immunity toMycobacterium tuberculosis, HIV-1 and Helicobacter pylori 显示文摘	Gringhuis SI denDunnen J Litjens M	2009	NatImmunol2009，10，10：	1
15	C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-depend-ent acetylation of transcription factor NF-kappaB 显示文摘	Gringhuis SI den Dunnen J Litjens M	2007	Immunity2007，26，5：	1
16	Psychosocial inter- ventions for patients with advanced cancer-a systematic review of the literature显示文摘	Uitterhoeve RJ Vernooy M Litjens M	2004	Br J Cancer2004，91，6：	1
17	Monomethylfumarate affects polariazation of monocyte-derived dendritic cells resulting in down-regulated Thl lymphocyte responses显示文摘	Litjens NH Rademaker M Ravensbergen B	2004	Eur J lmmunol2004，34，：	1
18	Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization显示文摘	Singh S K Streng-Ouwehand I Litjens M		0，，04：	1
19	Assessment of prostate cancer aggressiveness using dynamic contrast-enhanced magnetic resonance imaging at 3 T显示文摘	Vos EK Litjens GJ Kobus T	2013	Eur Urol2013，64，3：	1
20	Beneficial effects of fumarate therapy in psoriasis vulgaris patients coincide with downregulation of type 1 cytokines显示文摘	Litjens NH Nibbering PH Barrois A J	2003	Br J Dermatol2003，148，：	1

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