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| 1 | Gut microbiome in primary sclerosing cholangitis:A review显示文摘Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by biliary inflammation and stricturing.Exploration of the pathogenesis of PSC in light of its association with inflammatory bowel disease(IBD)and the“gut-liver”axis is an emerging area of interest.A growing number of studies have begun to elucidate the role of the gut microbiota,its metabolites and its influence on host immune responses in the development of PSC and PSCIBD.Studies of the fecal microbiota have highlighted enriched levels of certain species,including Veillonella,Streptococcus and Enterococcus,among others.A heightened immune response to enteric dysbiosis and bacterial translocation have also been implicated.For example,Klebsiella pneumoniae strains derived from gnotobiotic mice transplanted with PSC-IBD microbiota were found to induce pore formation in human intestinal epithelial cells and enhanced Th17 responses.Gut microbes have additionally been hypothesized to be implicated in PSC pathogenesis through their role in the synthesis of various metabolites,including bile acids(BAs),which function as signaling molecules with important gut and hepatic effects.An expanded knowledge of the gut microbiome as it relates to PSC offers critical insight into the development of microbe-altering therapeutic interventions,such as antibiotics,nutritional interventions and fecal microbial transplantation.Some of these have already shown some preliminary evidence of benefit.Despite exciting progress in the field,much work remains to be done;areas that are particularly lacking include functional characterization of the microbiome and examination of pediatric populations.In this review,we summarize studies that have investigated the microbiome in PSC and PSC-IBD as well as putative mechanisms,including the potential role of metabolites,such as BAs.We then briefly review the evidence for interventions with microbe-altering properties for treating PSC. | Rebecca Little Eytan Wine Binita M Kamath Anne M Griffiths Amanda Ricciuto | 2020 | World Journal of Gastroenterology2020，26，21： | 5 |
| 2 | Kinetics of CO2 with primary and secondary amines in aqueous solutions显示文摘 | Little R J Versteeg G F Van Swaaij W P M | 1992 | Chem Eng Sci1992，47，： | 3 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | A clinical overview of WT1 gene mutations 显示文摘 | Little M Wells C | 1997 | Hum Mutat1997，9，3： | 1 |
| 5 | Microbiological study of cooked crustaceans and molluscan shellfish from UK production and retail establishments显示文摘 | Little C L Greenwood M | 2007 | Int J Environ Health Res2007，17，3： | 1 |
| 6 | 显示文摘 | Kinloch A J Little M S G Watts J F | 2000 | Aeta Mater2000，48，： | 1 |
| 7 | Intravenous bisphosphonate therapy for traumatic os- teoneerosis of the femoral head in adolescents显示文摘 | Ramachandran M Ward K Brown RR Munns CF Cowell CT Little DG | 2007 | J Bone Joint Surg Am2007，89，： | 1 |
| 8 | Access recirculation in temporary hemodialysis catheters as measured by the saline dilution technique显示文摘 | Little M A Conlon P J Walshe J J | 2000 | Am J Kindney Dis2000，36，6： | 1 |
| 9 | Struc-ture of the FoxMl DNA-recognition domain bound to a pro-moter sequence显示文摘 | Little D R Alvarez Fernandez M Stein A | 2010 | Nucl Acids Res2010，38，13： | 1 |
| 10 | Horrow, esarean delivery scar ec- topic pregnancy 显示文摘 | Elizabeth A Little Babar M | 2010 | Trasound Quarterly2010，6，2： | 1 |
| 11 | A functional phylogenomic view of the seed plants显示文摘 | Lee EK Cibrian-Jaramillo A Kolokotronis SO Katari MS Stamatakis A Ott M Chiu JC Little DP Stevenson DW McCombie WR | | 0，，： | 1 |
| 12 | Comparison of three strategies to delineate the bowel for whole pelvis IMRT of prostate cancer显示文摘 | anguineti G Little M Endres | 2008 | Radiother Oncol2008，88，1： | 1 |
| 13 | MAXBAND:a program for setting signals on arteries and triangularnetworks显示文摘 | LITTLE J D C KELSON M D GARTNER N H | 1981 | Transportation Research Record1981，，795： | 1 |
| 14 | The Impact of Channel Leadership Behavior on Intrachannel Conflict 显示文摘 | Patrick L Schul William M Pride and Taylor L Little | 1983 | Journal of Marketing1983，47，3： | 1 |
| 15 | Estimating Nonlinear Parameters in the Multinomial Logit Model 显示文摘 | Fader P S Lattin J M Little J D C | 1992 | Marketing Science1992，11，4： | 1 |
| 16 | Embodied rural geographies:developing research agendas显示文摘 | Little J Leyshon M | 2003 | Progress in Human Geography2003，27，3： | 1 |
| 17 | Structural and functional studies of UDP-glucuronosyhrans- fcrases显示文摘 | RADOMINSKA-PANDYA A CZERNIK P J LITTLE J M | 1999 | Drug Metab Rev1999，31，4： | 1 |
| 18 | Amoxicillin for acute lower- re- spiratory -tract infection in primary care when pneumonia is not sus- pected : a 12 - country, randomised, placebo - controlled trial 显示文摘 | Little P Stuart B Moore M | 2013 | Lancet Infect Dis2013，13，2： | 1 |
| 19 | Separation control with nanosecond-pulse-driven dielectric barrier discharge plasma actuators 显示文摘 | LITTLE J TAKASHIMA K NISHIHARA M | 2012 | AIAA Journal2012，50，2： | 1 |
| 20 | Robust statistical modelling using the t distribution显示文摘 | Lange K L Little R J A Taylor J M G | 1989 | Journal of American Statistical Association1989，84，： | 1 |
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