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| 1 | Outcome of the efficacy of Chinese herbal medicine for functional constipation:A systematic review and meta-analysis显示文摘BACKGROUND Functional constipation(FC)is a common and chronic gastrointestinal disease and its treatment remains challenging.AIM To evaluate the efficacy and safety of Chinese herbal medicine(CHM)on efficacy rate,global symptoms,bowel movements and the Bristol Stool Scale score in patients with FC by summarizing current available randomized controlled trials(RCTs).METHODS RCTs with CHM to treat FC were identified by a systematic search of six databases from inception to October 20,2020.Two independent reviewers assessed the quality of the included articles and extracted data.Meta-analyses were performed to odds ratio(OR),mean differences(MD)and 95%confidence interval(CI)using random-effects models.Subgroup analyses and sensitivity analyses were used to explore and interpret the sources of heterogeneity.The funnel plot,Begg’s test and Egger’s test were used to detect publication bias.RESULTS Ninety-seven studies involving 8693 patients were included in this work.CHM was significantly associated with a higher efficacy rate(OR:3.62,95%CI:3.19-4.11,P<0.00001)less severe global symptoms(OR:4.03,95%CI:3.49-4.65,P<0.00001)compared with control treatment,with the low heterogeneity between studies(I2=0%,P=0.76).CHM was also associated with more frequent bowel movements(MD 0.83,95%CI:0.67-0.98,P<0.00001),a lower score on the Bristol Stool Scale(OR:1.63,95%CI:1.15-2.32,P<0.006),and a not significant recurrence rate(OR:0.47,95%CI:0.22-0.99,P=0.05).No serious adverse effects of CHM were reported.CONCLUSION In this meta-analysis,we found that CHM may have potential benefits in increasing the number of bowel movements,improving stool characteristics and alleviating global symptoms in FC patients.However,a firm conclusion could not be reached because of the poor quality of the included trials.Further trials with higher quality are required. | Zipan Lyu Yibo Fan Yang Bai Tao Liu Linda LD Zhong Hui-Feng Liang | 2022 | World Journal of Clinical Cases2022，10，15： | 4 |
| 2 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 3 | Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease 显示文摘 | Stubbs J Liu S Quarles LD | 2007 | Semin Dial2007，20，： | 1 |
| 4 | Combinatorial effects of lapatinib and rapamycin in triple-negative breast can- cer cells显示文摘 | Liu T Yacoub R Taliaferro-Smith LD | 2011 | Mol Cancer Ther2011，10，8： | 1 |
| 5 | Denonvilliers' fascia in women and its relationship with the fascia propria of the rectum examined by successive slices of celloidin-embedded pelvic viscera显示文摘 | Zhai LD Liu J Li YS | 2009 | Dis Colon Rectum2009，52，9： | 1 |
| 6 | Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity显示文摘 | Liu Z Falo LD Jr You Z | 2011 | J Immunol2011，187，1： | 1 |
| 7 | MK-801 protects against carbon monoxide-induced hearing loss 显示文摘 | Fechter LD Liu Y | 1995 | Toxicol Appl Pharmacol1995，132，： | 1 |
| 8 | Remarkable Enhancement in Thermoelectric Performance of Bi Cu Se O by Cu Deficiencies显示文摘 | Liu Y Zhao LD Liu YC | 2011 | Journal of the American Chemical Society2011，133，20： | 1 |
| 9 | Effects of tetrodotoxin (TTX) inactivation of the central nucleus of the amygdala (CNA) on dark period sleep and activity 显示文摘 | Sanford LD Yang L Liu X | 2006 | Brain Res2006，1084，： | 1 |
| 10 | Middle cerebral artery occlusion model in rodents: methods and potential pitfalls 显示文摘 | Liu F McCullough LD | 2011 | J Biomed Biotechnol2011，2011，46： | 1 |
| 11 | Lack of depotentiation at basal ganglia output neurons in PD patients with levodopa-induced dyskinesia显示文摘 | Prescott IA Liu LD Dostrovsky JO | 2014 | Neurobiology of disease2014，12，6： | 1 |
| 12 | Autosomal tri- somy and maternal use of multivitamin supplements 显示文摘 | Botto LD Mulinare J Yang Q Liu Y Erickson ID | 2004 | Am J Med Genet2004，125，： | 1 |
| 13 | Arbuscular mycorrhizal fungi associated with common pteridophytes in Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Mycorrhiza2004，14，1： | 1 |
| 14 | Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease显示文摘 | Stubbs J Liu S Quarles LD | 2007 | Semin Dial2007，20，4： | 1 |
| 15 | Survey of arbuscular mycorrhizal fungi in deforested and natural forest land in the subtropical region of Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Plant and Soil2004，261，12： | 1 |
| 16 | Preparation and in vitro /in vivo evaluation of sustained-release metformin hydrochloride pellets 显示文摘 | Hu LD Liu Y Tang X | 2006 | Eur J Pharm Biopharm2006，64，2： | 1 |
| 17 | Expression of na-k-cl cotransporter and edema formation are age dependent after ischemic stroke显示文摘 | Liu F Akella P Benashski SE Xu Y McCullough LD | | 0，，2： | 1 |
| 18 | Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination 显示文摘 | Xu HX Chen LD Liu LN | 2012 | Br J Radiol2012，85，1016： | 1 |
| 19 | Hepatecyte growth factor protects renal epithelial cells from apoptotic cell death显示文摘 | Liu Y Sun AM Dworkin LD | 1998 | Biochem Biophys Bes Commun1998，246，3： | 1 |
| 20 | Middle cerebral artery occlusion model in rodents: methods and potential pitfalls 显示文摘 | Liu F Mccullough LD | 2011 | J Biomed Biotechnol2011，2011，46： | 1 |
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