维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

1篇 您的检索式：作者名="Liuxing Qin"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure显示文摘Cholesterol-25-hydroxylase(CH25 H)is a membrane protein associated with endoplasmic reticulum,and it is an interferon-stimulated factor regulated by interferon.CH25 H catalyzes cholesterol to produce 25-hydroxycholesterol(25 HC)by adding a second hydroxyl to the 25 th carbon atom of cholesterol.Recent studies have shown that both CH25 H and 25 HC could inhibit the replication of many viruses.In this study,we found that ectopic expression of CH25 H in HEK-293 T and BHK-21 cell lines could inhibit the replication of Seneca Valley virus(SVV)and that there was no species difference.On the other hand,the knockdown of CH25 H could enhance the replication of SVV in HEK-293 T and BHK-21 cells,indicating the importance of CH25 H.To some extent,the CH25 H mutant without hydroxylase activity also lost its ability to inhibit SVV amplification.Further studies demonstrated that 25 HC was involved in the entire life cycle of SVV,especially in repressing its adsorption process.This study reveals that CH25 H exerts the advantage of innate immunity mainly by producing 25 HC to block virion adsorption.	Hui Li Zekai Zhao Xiangmin Li Liuxing Qin Wei Wen Huanchun Chen Ping Qian	2021	Virologica Sinica2021，36，5：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费