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20篇 您的检索式:作者名="Livingston MJ"
    题名 作者 年代 出处 被引量
1p53/microRNA-214/ULK1信号通路调控的自噬在糖尿病肾病中的作用机制显示文摘目前有多个研究证实糖尿病肾病中存在自噬失调,但其潜在的病理机制并不清楚。该研究通过对糖尿病小鼠及糖尿病患者肾脏组织分析发现,自噬反应在肾脏中均明显被抑制。特异性敲除小鼠肾脏近端小管的自噬相关基因Atg6后可抑制自噬作用,导致糖尿病小鼠肾脏肥大,加重小管损伤、炎症反应及纤维化,最终导致蛋白尿增加,说明自噬在糖尿病肾病中起保护作用。与此同时,研究发现糖尿病组织中小RNA214(miR-214)表达上调,从而抑制下游unc-51样自噬相关激活酶(ULK1)的表达,最终导致自噬表达降低。特异性沉默肾脏近端小管miR-214的表达可减少对ULK1的抑制,阻止了糖尿病肾病肾脏体积的增大,降低了蛋白尿水平。Ma Z Li L Livingston MJ 梅淑钦(编译) 2021中华医学杂志2021,101,42:2
2Autophagy in acute kidney injury and repair显示文摘He L Livingston MJ Dong Z 2014Nephron Clin Practice2014,127,14:1
3Autophagy in acute kidney injury and repair显示文摘He L Livingston MJ Dong Z 2014Nephron Clin Pract2014,127,14:1
4Comprehensive identification and characterization of diallelic insertion-deletion polymorphisms in 330 human candidate genes显示文摘Bhangale TR Rieder MJ Livingston RJ 2005Hum Mol Genet2005,14,91:1
5Closed suction surgical wound drainage after orthopaedic surgery显示文摘Parker MJ Livingstone V Clifton R 0,,:1
6Closed suction surgical wound drainage after orthopaedic surgery 显示文摘Parker MJ Livingstone V Clifton R 2007Cochrane Database Syst Rev2007,,00:1
7Autophagy in acute kidney injury and repair显示文摘He L Livingston MJ Dong Z 2014Nephmn Clin Pract2014,127,14:1
8Computer hexapod assisted orthopaedic surgery(CHAOS)in the correction of long bone fracture and deformity显示文摘Rogers MJ McFadyen I Livingstone JA 2007J Orthop Trauma2007,5,:1
9Autophagy in acute kidney injury 显示文摘Livingston MJ Dong Z 2014Semin Nephrol2014,34,4:1
10Autophagy in acute kidney injury and repair显示文摘He L Livingston MJ Dong Z 2014Nephron Clin Pract2014,127,14:1
11Autophagy in acute kidney injury显示文摘Livingston MJ Dong Z 2014Semin Nephrol2014,34,:1
12Closed suction surgical wound drainage after orthopaedic surgery显示文摘Parker MJ Livingstone V Clifton R 0,,:1
13Vaccines containing purified GM2 ganglioside elicit GM2 antibodies in melanoma patients显示文摘 Natoli EJ Calves MJ 1987Proc Natl Acad Sci USA1987,84,9:1
14Effect of molecular size on permeability coefficients in human dentine显示文摘Pashley DH Livingston MJ 1987Arch Oral Biol1987,23,4:1
15Autophagy in acute kidney injury 显示文摘Livingston MJ Dong Z 2014Semi Nephrol2014,34,1:1
16Dentin permeabil- ity: determinants of hydraulic conductance 显示文摘Reeder JR Walton RE Livingston MJ 1978J Dent Res1978,57,2:1
17Computer hexapod assisted orthopaedic surgery (CHAOS) in the correction of long bone fracture and deformity显示文摘Rogers MJ McFadyen I Livingstone JA 0,,5:1
18Characterization of IgG and IgM antibodies induced in melanoma patients by immunization with purified GM2 ganglioside 显示文摘Livingston PO Riner G Srivastava P Padavan M Calves MJ Oengen HF 1989Cancer Res1989,49,24:1
19Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy 显示文摘Wilson CC Newman MJ Livingston BD 2008Clin Vaccine Immunol2008,15,6:1
20Comprehensive identification and characterization of diallelic insertion-deletion palymorphisms in 330 human candidate genes显示文摘Bhangale TR Rieder MJ Livingston RJ 2005Hum Mal Genet2005,14,1:1
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