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| 1 | Metabolic phenotype of isoflavones differ among female rats,pigs,monkeys,and women显示文摘 | Liwei Gu Suzanne E Ronald L | 2006 | J Nutr2006，136，3： | 1 |
| 2 | The IFITM proteins inhibit HIV-1 infection显示文摘 | Jennifer L Qinghua P Liwei R | 2011 | J Virology2011，85，5： | 1 |
| 3 | Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect显示文摘 | Liwei C Ning Y Yan L | 2014 | PLoS One2014，9，10： | 1 |
| 4 | A Kind of Stochastic Duel Model for GuerrillaWar显示文摘 | Liwei L Jun Y Zhi G | 2006 | European Journal of Operational Reseach2006，171，2： | 1 |
| 5 | Anti-nociCeptive and anti-inflammatory activity caused by Cistanche deserticola in rodents显示文摘 | Liwei L Mingtsuen H Fanhsiu T | 2002 | J Ethnophannacol2002，83，3： | 1 |
| 6 | Delayed abscission and shorter internodes correlate with a reduction in the ethylene receptor LeETR1 transcript in transgenic tomato显示文摘 | CATHERINE A W NICHOLAS N L LIWEI C | 2002 | Plant Physiology2002，128，： | 1 |
| 7 | Astudyonisomerizationofvinylnorbornene(Ⅱ)-(Na2O-Na)/(γ-Al2O3)typesuperbasecatalyst[J]显示文摘 | CuiChangyi(崔昌亿) WangXun(王浔) DingYuansheng(丁元生) LüWeidong(吕伟东) WangHongbin(王洪斌) LiWei(李伟) WangBing(王兵) | | 化工科技0，，： | 1 |
| 8 | PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling显示文摘Oral squamous cell carcinoma(OSCC)has a high incidence of metastasis.Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary;however,only a few patients with OSCC respond to this treatment.Therefore,it is essential to gain insights into the molecular mechanisms underlying the growth and metastasis of OSCC.In this study,we analysed the expression levels of protein kinase D3(PKD3)and PD-L1 and their correlation with the expression of mesenchymal and epithelial markers.We found that the expression of PKD3 and PD-L1 in OSCC cells and tissues was significantly increased,which correlated positively with that of mesenchymal markers but negatively with that of epithelial markers.Silencing PKD3 significantly inhibited the growth,metastasis and invasion of OSCC cells,while its overexpression promoted these processes.Our further analyses revealed that there was positive feedback regulation between PKD3 and PD-L1,which could drive EMT of OSCC cells via the ERK/STAT1/3 pathway,thereby promoting tumour growth and metastasis.Furthermore,silencing PKD3 significantly inhibited the expression of PD-L1,and lymph node metastasis of OSCC was investigated with a mouse footpad xenograft model.Thus,our findings provide a theoretical basis for targeting PKD3 as an alternative method to block EMT for regulating PD-L1 expression and inhibiting OSCC growth and metastasis. | Bomiao Cui Jiao Chen Min Luo Yiying Liu Hongli Chen Die Lü Liwei Wang Yingzhu Kang Yun Feng Libin Huang Ping Zhang | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 9 | Additional Gene Therapy with rAAV-wt-p53 enhanced the efficacy of cisplatin in human bladder cancer cells显示文摘 | Ruifa H Liwei L Binxin L | 2006 | Urol Int2006，77，4： | 1 |
| 10 | Occurrence and biological significance of proanthocyanidins in the American diet 显示文摘 | Ronald L Prior Gu Liwei | 2005 | Phytochemistry2005，66，： | 1 |
| 11 | Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples显示文摘 | PRIOR R L HOANG H GU Liwei | 2003 | Journal of Agricultural and Food Chemistry2003，51，11： | 1 |
| 12 | eIF4E phosphorylation pro- motes Tumorigenesis and is associated with prostate cancer progression显示文摘 | Luc F Liwei Rong Ola L | 2010 | Proc Natl Acad Sci USA2010，107，14： | 1 |
| 13 | Association between genetic variantsin glutathione peroxidase 1 gene and risk of prostate cancer: a meta-a-nalysis显示文摘 | Liwei L Wei Z Ruifa H | 2012 | Mol Biol Rep2012，39，9： | 1 |
| 14 | The RhHB1/RhLOX4 module affects the dehydration tolerance of rose flowers(Rosa hybrida)by fine-tuning jasmonic acid levels显示文摘Phytohormones are key factors in plant responsiveness to abiotic and biotic stresses,and maintaining hormone homeostasis is critically important during stress responses.Cut rose(Rosa hybrida)flowers experience dehydration stress during postharvest handling,and jasmonic acid(JA)levels change as a result of this stress.However,how JA is involved in dehydration tolerance remains unclear.We investigated the functions of the JA-and dehydration-induced RhHB1 gene,which encodes a homeodomain-leucine zipper Iγ-clade transcription factor,in rose flowers.Silencing RhHB1 decreased petal dehydration tolerance and resulted in a persistent increase in JA-Ile content and reduced dehydration tolerance.An elevated JA-Ile level had a detrimental effect on rose petal dehydration tolerance.RhHB1 was shown to lower the transient induction of JA-Ile accumulation in response to dehydration.In addition to transcriptomic data,we obtained evidence that RhHB1 suppresses the expression of the lipoxygenase 4(RhLOX4)gene by directly binding to its promoter both in vivo and in vitro.We propose that increased JA-Ile levels weaken the capacity for osmotic adjustment in petal cells,resulting in reduced dehydration tolerance.In conclusion,a JA feedback loop mediated by an RhHB1/RhLOX4 regulatory module provides dehydration tolerance by fine-tuning bioactive JA levels in dehydrated flowers. | Youwei Fan Jitao Liu Jing Zou Xiangyu Zhang Liwei Jiang Kun Liu Peitao Lü Junping Gao Changqing Zhang | 2020 | Horticulture Research2020，7，1： | 1 |
| 15 | Additional gene therapy with rAAV-wt-p53 enhanced the efficacy of cisplatin in human bladder cancer cells显示文摘 | Ruifa H Liwei L Binxin L | 2005 | Urol Int2005，77，4： | 1 |
| 16 | Regulation of rose petal dehydration tolerance and senescence by RhNAP transcription factor via the modulation of cytokinin catabolism显示文摘Petals and leaves share common evolutionary origins but have different phenotypic characteristics,such as the absence of stomata in the petals of most angiosperm species.Plant NAC transcription factor,NAP,is involved in ABA responses and regulates senescence-associated genes,and especially those that affect stomatal movement.However,the regulatory mechanisms and significance of NAP action in senescing astomatous petals is unclear.A major limiting factor is failure of flower opening and accelerated senescence.Our goal is to understand the finely regulatory mechanism of dehydration tolerance and aging in rose flowers.We functionally characterized RhNAP,an AtNAP-like transcription factor gene that is induced by dehydration and aging in astomatous rose petals.Cytokinins(CKs)are known to delay petal senescence and we found that a cytokinin oxidase/dehydrogenase gene 6(RhCKX6)shares similar expression patterns with RhNAP.Silencing of RhNAP or RhCKX6 expression in rose petals by virus induced gene silencing markedly reduced petal dehydration tolerance and delayed petal senescence.Endogenous CK levels in RhNAP-or RhCKX6-silenced petals were significantly higher than those of the control.Moreover,RhCKX6 expression was reduced in RhNAP-silenced petals.This suggests that the expression of RhCKX6 is regulated by RhNAP.Yeast one-hybrid experiments and electrophoresis mobility shift assays showed that RhNAP binds to the RhCKX6 promoter in heterologous in vivo system and in vitro,respectively.Furthermore,the expression of putative signal transduction and downstream genes of ABA-signaling pathways were also reduced due to the repression of PP2C homolog genes by RhNAP in rose petals.Taken together,our study indicates that the RhNAP/RhCKX6 interaction represents a regulatory step enhancing dehydration tolerance in young rose petals and accelerating senescence in mature petals in a stomata-independent manner. | Jing Zou Peitao Lü Liwei Jiang Kun Liu Tao Zhang Jin Chen Yi Yao Yusen Cui Junping Gao Changqing Zhang | 2021 | Molecular Horticulture2021，1，1： | 0 |
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