| 1 | The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital.based multi.center study显示文摘Background: Stage at diagnosis and molecular subtype are important clinical factors associated with breast cancer patient survival. However, subgroup survival data from a large study sample are limited in China.To estimate the survival differences among patients with different stages and various subtypes of breast cancer, we conducted a hospital-based multi-center study on breast cancer in Beijing, China.Methods: All resident patients diagnosed with primary, invasive breast cancer between January 1,2006 and December 31,2010 from four selected hospitals in Beijing were included and followed up until December 31,2015. Hospitalbased data of stage at diagnosis, hormone receptor status, and selected clinical characteristics, including body mass index(BMI), menopausal status, histological grade, and histological type, were collected from the medical records of the study subjects. Overall survival(OS) and cancer-specific survival(CSS) were estimated. Cox proportional hazards models were employed to evaluate the associations of stage at diagnosis and molecular subtype with patient survival.Results: The 5-year OS and CSS rates for all patients were 89.4% and 90.3%. Survival varied by stage and molecular subtype. The 5-year OS rates for patients with stage I, Ⅱ, Ⅲ, and IV diseases were 96.5%, 91.6%, 74.8%, and 40.7%,respectively, and the corresponding estimates of 5-year CSS rates were 97.1%, 92.6%, 75.6%, and 42.7%, respectively.The 5-year OS rates for patients with luminal A, luminal B, HER2, and triple-negative subtypes of breast cancer were92.6%, 88.4%, 83.6%, and 82.9%, respectively, and the corresponding estimates of 5-year CSS rates were 93.2%, 89.1 %,85.4%, and 83.5%, respectively. Multivariate analysis showed that stage at diagnosis and molecular subtype were important prognostic factors for breast cancer.Conclusions: Survival of breast cancer patients varied significantly by stage and molecular subtype. Cancer screening is encouraged for the early detection and early diagnosis of breast cancer. More advanced therapies and health care policies are needed on HER2 and triple-negative subtypes. | Tingting Zuo Hongmei Zeng Huichao Li Shuo Liu Lei Yang Changfa Xia Rongshou Zheng Fei Ma Lifang Liu Ning Wang Lixue Xuan Wanqing Chen | 2017 | Chinese Journal of Cancer2017，36，11： | 18 |
| 2 | Recent advances of morphology adaptive nanomaterials for anti-cancer drug delivery显示文摘The morphology of nanomaterials combines the characteristics of their size, shape and spatial structure. Owing to the improved spatiotemporal control of the nanocarriers for anti-cancer drug delivery, the morphology adaptive nanomaterials have received tremendous attention in the field of nanomedicine, while they are able to respond through chemical or physical change. In this review, we summarize the recent advancements of morphology adaptive nanomaterials and their application in anti-cancer drug delivery system, wherein the size, shape and spatial structure of nanocarriers can be changed to adapt the complex living system, thus overcoming the pathological barriers in drug delivery. The overview of the recent examples shows that each step of delivery process can be improved by the morphology adaption, which represents the great potential for clinic translation of morphology adaptive nanomaterials. | Dongbing Cheng Zengying Qiao Lixue Xuan Hao Wang | 2020 | Progress in Natural Science:Materials International2020，30，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员