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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 3 | Kinetics g plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma 显示文摘 | Lo Y M Leung S F Chart L Y | 2000 | Cancer Res2000，60，： | 1 |
| 4 | Molecular prognostication of nasopharygeal carcinoma by quantitative analysis Of circulating Epstein-Barr virus DNA 显示文摘 | LO Y M LEUNG S F CHAN L Y | 2000 | CancerRes2000，60，： | 1 |
| 5 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 6 | Survivin as prognostic factor in squamous cell carcinoma of the oral cavity显示文摘 | Lo Muzio L Farina A Carinci F | 2005 | Cancer Lett2005，225，1： | 1 |
| 7 | The effect of humidity and state of water surfaces on deposition of aerosol particles onto a water surface显示文摘 | LO A K F ZHANG L M SIEVERING H | 1999 | Atmospheric Environment1999，33，28： | 1 |
| 8 | Measurement of corrosion and temperature using a single-pitch Bragg grating fiber sensor显示文摘 | Lo Y L Xiao F Y | 1998 | J Intell Mater Syst Struct1998，9，10： | 1 |
| 9 | Effects of pre-preg-nancy physical activity and maternal BMI on gestational weight gain and birth weight显示文摘 | Lo?f M Hilakivi-Clarke L Sandin S | | 0，，05： | 1 |
| 10 | Natural and experimental infection of white spot syndrome virus (WSSV) in benthic larvae of mud crab Scylla serrata显示文摘 | Chen L L Lo C F Chiu Y L | 2000 | Dis Aquat Organ2000，40，： | 1 |
| 11 | Micro-beamer based on MEMS micro-mirrors and laser light source 显示文摘 | Winter C Fabre L Conte F Lo | 2009 | Proeedia Chemistry(S1876-6196)2009，1，1： | 1 |
| 12 | Field Instrumentation of a Multiple Tunnels Interaction Problem 显示文摘 | Lo K W Chong L K Leung L F | 1998 | Tunnels and Tunnelling1998，18，： | 1 |
| 13 | Synergetic stress of acids and ammonium on the shift in the methanogenic pathways during thermophilic anaerobic digestion of organics 显示文摘 | Lo F Hao L Guan D | 2013 | Water Research2013，47，7： | 1 |
| 14 | Influence of signalpeptide truncations on the functional expression of Escherichia coli gamma-glutamyltranspeptidase 显示文摘 | Lo H F Chou W M Chen P J Lin L L | 2008 | J Basic Microbiol2008，48，： | 1 |
| 15 | Total recovery of resources and energy from rice straw using microwave - induced pyrolysis 显示文摘 | Huang Y F Kuan W H Lo S L | 2008 | Bioresource Technology2008，99，： | 1 |
| 16 | Multimedia education programme for patients with a stoma: effectiveness evaluation 显示文摘 | Lo S F Wang Y T Wu L Y | 2011 | J Adv Nurs2011，67，1： | 1 |
| 17 | Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis显示文摘 | LO L MCLENNAN S V WILLIAMS P F | 2011 | J Hepatol2011，55，2： | 1 |
| 18 | Combination of onclansetron and dexaethasone in the prophylaxis of postoperative nausea and vomiting显示文摘 | Lo pez-Olaondo L Carrascosa F Carrascosa F | 1996 | British Journal of Anesthesia1996，76，6： | 1 |
| 19 | Hybrid approach using counterpropagation neural network for power-system network reduction显示文摘 | L J Peng J F Macqueen | 1997 | IEE Proceedings-Generation Transmission and Distribution1997，14，2： | 1 |
| 20 | Supplementary health benefits of soy aglycons of isoflavone by improvement of serum biochemical at- tributes,enhancement of liver antioxldative capacities and protec- tion of vaginal epithelium of ovariectomized rats 显示文摘 | Lien T F Hsu Y L Lo D Y | 2009 | Nutr Metab (kond)2009，9，： | 1 |
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