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| 1 | Management of biliary complications after orthotopic liver transplantation:The role of endoscopy显示文摘Biliary complications are signifi cant causes of morbidity and mortality after orthotopic liver transplantation (OLT). The estimated incidence of biliary complications after OLT ranges between 10%-25%,however,these numbers continue to decline due to improvement in surgical techniques. The most common biliary complications are strictures (both anastomotic and non-anastomotic) and bile leaks. Most of these problems can be appropriately managed with endoscopic retrograde colangiography (ERC). Other complications such as bile duct stones,bile casts,sphincter of Oddi dysfunction,and hemobilia,are less frequent and also can be managed with ERC. This article will review the risk factors,diagnosis,and endoscopic management of the most common biliary complications after OLT. | Maria C Londoo Domingo Balderramo Andrés Cárdenas | 2008 | World Journal of Gastroenterology2008，14，4： | 22 |
| 2 | A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic juice grape‘Concord’显示文摘‘Concord’,the most well-known juice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in berries.This aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species V.vinifera.Here we discovered homology-induced promoter indels as a major genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA biosynthesis.We found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other V.labrusca-derived grapes.These promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis germplasm.Moreover,functional impact of these indels was validated in transgenic Arabidopsis.Superimposed on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some V.vinifera grapes.Elucidation of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding. | Yingzhen Yang JoséCuenca Nian Wang Zhenchang Liang Honghe Sun Benjamin Gutierrez Xiaojun Xi Jie Arro YiWang Peige Fan Jason Londo Peter Cousins Shaohua Li Zhangjun Fei Gan-Yuan Zhong | 2020 | Horticulture Research2020，7，1： | 3 |
| 3 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Interferon-Free Regimens in the Liver-Transplant Setting显示文摘 | Sabela Lens Martina Gambato María-Carlota Londo?o Xavier Forns | 2014 | Semin Liver Dis2014，，01： | 2 |
| 5 | Association between CSF biomarkers and incipient Alzheimer’s disease in patients with mild cognitive impairment: a follow-up study显示文摘 | Oskar Hansson Henrik Zetterberg Peder Buchhave Elisabet Londos Kaj Blennow Lennart Minthon | 2006 | Lancet Neurology2006，，3： | 2 |
| 6 | Telomere length heterogeneity and chromosome instability显示文摘 | Londoňo-Vallejo JA | 2004 | Cancer Letters2004，212，： | 1 |
| 7 | Telomeric function of mammalian telomerases at short telomeres显示文摘 | Fakhoury J Marie-Egyptienne DT Londo?o-Val ejo JA | | 0，，： | 1 |
| 8 | Chromosomal damage and ageing:effect on micronuclei frequency in peripheral blood lymphocytes显示文摘 | Londo C Forni A | 1999 | Age Ageing1999，28，： | 1 |
| 9 | Role of PAT proteins in lipid metabolism 显示文摘 | LONDOS C SZTALRYD C TANSEY J T | 2005 | Biochimie2005，87，1： | 1 |
| 10 | Role of PAT proteins in lipid metabolism 显示文摘 | Londos C Sztalryd C Tansey J T | 2005 | Biochimie2005，87，1： | 1 |
| 11 | Income distribution,factor endowments,and trade openness显示文摘 | Spilimbergo A Londo?o J L Székely M | 1999 | Journal of development Economics1999，59，77： | 1 |
| 12 | Long-term outcome and prediction models of activities of daily living in Alzheimer disease with cholinesterase inhibit or treatment显示文摘 | Wattmo C Wallin A K Londos E | 2011 | Alzheimer Dis Assoc Disord2011，25，： | 1 |
| 13 | On the control of lipolysis in adipocytes显示文摘 | Londos C Brasaemle D L Sehultz C J | 1999 | Annals of the New York Academy of Sciences1999，892，： | 1 |
| 14 | Perilipin:proteins associated with intracellular neutral lipid droplets in adipocytes and steoidogenic cells显示文摘 | Londos C Brasaemh DL Gruia-Gray J | 1995 | Biochem Soc Trans1995，23，： | 1 |
| 15 | Degradation of perilipin is mediated through ubiquitination- protea- some pathway 显示文摘 | XU G SZTALRYD C LONDOS C | 2006 | Biochim Biophys Acta2006，1761，： | 1 |
| 16 | The Wnt/β-catenin pathway in ovarian cancer:a review显示文摘 | Arend RC Londo?o-Joshi AI Straughn JM Jr | 2013 | Gynecol Oncol2013，131，3： | 1 |
| 17 | Origins and population genetics of weedy red rice in the USA 显示文摘 | LONDO J P SCHAAL B A | 2007 | Molocular Ecology2007，16，： | 1 |
| 18 | Phylogeography of Asian wild rice,Oryza rufipogon, reveals multiple independent domestications of cultivated rice, Oryza sativa 显示文摘 | LONDO J P CHIANG Y C HUNG K H | 2006 | Proc Natl Acad Sci USA2006，103，25： | 1 |
| 19 | On the control of lipolysis in adipocytes显示文摘 | Londos C Brasaemle D L Schultz C J | 1999 | Ann N Y Acad Sci1999，892，： | 1 |
| 20 | Degradation of perilipin is mediated through ubiquitination-proteasome pathway显示文摘 | XU G SZTALRYD C LONDOS C | 2006 | Biochim Biophys Acta2006，1761，1： | 1 |
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