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| 1 | 抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟显示文摘目的数值模拟抗血管生成因子Angiostatin和Endostatin对肿瘤血管生成的影响。方法建立肿瘤内外血管生成的二维离散数学模型。模型耦合两种抗血管生成因子Angiostatin和Endostatin的抑制效应,数值模拟在促血管生成因子诱导下肿瘤微血管网生成,讨论血管生成抑制因子的影响。结果抗血管生成因子Angiostatin对肿瘤内外血管网络生成的速度和成熟度有抑制作用。抗血管生成因子Angiostatin和Endostatin耦合作用时,在肿瘤血管生成的早期有明显的抑制效应;在肿瘤血管生成的中后期,它们可以降低肿瘤血管化程度。结论本文模型能够较好的模拟抗血管生成因子Angiostatin和Endostatin对内皮细胞迁移和增殖的抑制作用。 | 赵改平 高昊 吴洁 许世雄 Collins MW LONG Quan Carola Koenig Padhani AR | 2006 | 医用生物力学2006，21，4： | 10 |
| 2 | A histological study on the effect of different periods of orthodontic force on the innervation and di-mensions of the cat periodontal ligament显示文摘 | Long A Loescher AR Robinson PP | 1996 | Arch Oral Biol1996，41，89： | 1 |
| 3 | Isolation of drug residues from tissues by solid phase dispersion显示文摘 | Barker SA Long AR Short CR | 1989 | J Chromatogr A1989，475，2： | 1 |
| 4 | Matrix solid phase dispersion isolation and liquid chromatographic determination of oxytetracycline in catfish ( lctalurus punctatus ) muscle tissue显示文摘 | Long AR Hsien LC Malbrough MS | 1990 | JAOAC lnt1990，73，6： | 1 |
| 5 | Long-term results of CD+34 cell Transplantation in children with neuroblastoma显示文摘 | Kanold J Long G Migliaccio AR | 2000 | Med Pediatr Oncol2000，35，1： | 1 |
| 6 | Isolation of drug residues from tissues by solid phase dispersion显示文摘 | Barker SA Long AR Short CR | | 0，，： | 1 |
| 7 | A histological study on the effect of dif- ferent periods of orthodontic force on the innervation and dimensions of the cat periodontal ligament 显示文摘 | Long A Loescher AR Robinson PP | 1996 | Arch Oral Biol1996，41，89： | 1 |
| 8 | Matrix soild phase dispersion (MSPD) isolation and liquid chromatographic determination of clorsulon in milk显示文摘 | Barker SA Long AR | 1991 | Journal of Liquid Chromatography1991，14，15： | 1 |
| 9 | Cardiovascular renal disease, report of a case three thousand years ago显示文摘 | Long AR | 1931 | Arch Pathol (Chic)1931，12，： | 1 |
| 10 | A histological study on the effect of different periods of orthodontic force on the innervation and dimensions of the cat periodontal ligament 显示文摘 | Long A Loescher AR Robinson PP | 1996 | Arch Oral Biol1996，41，89： | 1 |
| 11 | Method for the isolation and liquid chromatographic determination of furazolidone in milk显示文摘 | Long AR Hsieh LC Malbrough MS | 1990 | J Agric Food Chem1990，38，02： | 1 |
| 12 | Matrix solid-phase dispersion (MSPD)isolation and liquid chromatographic determination of oxytetracycline,tetracycline,and chlortetracycline in milk 显示文摘 | Long AR Hsieh LC Malbrough MS | 1990 | J Assoc Off Anal Chem1990，73，3： | 1 |
| 13 | The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein显示文摘 | Miyauchi K Curran AR Long Y Kondo N lwamoto A Engelman DM Matsuda Z | 2010 | Retrovirology2010，7，： | 1 |
| 14 | A histological study on the effect of different periods of orthodontic force on the innervation and dimensions of the cat periodontal ligament显示文摘 | Long A Loescher AR Robinson PP | 1996 | Arch Oral Biol1996，41，89： | 1 |
| 15 | Isolation of drug residues from tissues by solid phase dispersion显示文摘 | Barker SA Long AR Short CR | 1989 | J Chromatogr1989，475，： | 1 |
| 16 | Matrix solid -phase dispersion (MSPD) isolation and liquid chromatographic determination of oxytetracycline,tetracycline,and chlortetracycline in milk显示文摘 | Long AR Hsieh LC Malbrough MS | 1990 | J Assoc Off Anal Chem1990，73，3： | 1 |
| 17 | Method for the isolation and liquid chromatographic determination of chloranphenicol in milk显示文摘 | Long AR Hsieh LC Malbrough MS | 1990 | J Agric Food Chem1990，38，： | 1 |
| 18 | 注射方式对二维实体肿瘤中药物输运影响的数值研究显示文摘目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不同的施药注射方式进行了探讨。结果MEC较小时各种注射方式效果接近;MEC较大时,比较适合采用短时间集中注射方式。结论对肿瘤进行药物注射策略选取时,应根据肿瘤具体特性,以及药物施加方式对肿瘤细胞产生的不同作用来组合设计相应的优化施药方案。 | 浏丹 许世雄 吴洁 卫晶晶 Long Quan Collins MW Carola Koenig 蒋雨平 Padhani AR | 2006 | 医用生物力学2006，21，4： | 0 |
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