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| 1 | Public Awareness and Mask Usage during the COVID-19 Epidemic:A Survey by China CDC New Media显示文摘An online survey conducted March 18–19,2020 on the official China CDC WeChat account platform was used to evaluate the effect of public education about masks usage during the new coronavirus disease 2019(COVID-19)epidemic.Chinese nationals older than 18 were eligible for the survey.The survey collected 5,761 questionnaires from the 31 provinces,municipalities,and autonomous regions of China's Mainland.99.7%and 97.2%of the respondents answered correctly that respiratory droplets and direct contact were the main transmission routes.73.3%of the respondents considered COVID-19 to be‘serious’or‘very serious’. | SUN Cheng Xi HE Bin MU Di LI Pei Long ZHAO Hong Ting LI Zhi Li ZHANG Mu Li FENG Lu Zhao ZHENG Jian Dong CHENG Ying CUI Ying LI Zhong Jie | 2020 | Biomedical and Environmental Sciences2020，33，8： | 2 |
| 2 | Correlation between Anxiety,Depression,and Sleep Quality in College Students显示文摘Sleep disorders will lead to difficulties in entering or maintaining sleep. Short-term sleep disorders will affect people’s attention and memory, and longterm sleep disorders will lead to a decline in human immunity and induce some potential physical diseases and psychological diseases such as anxiety symptoms and depressive symptoms. Facing pressure from study, life, employment, and other aspects, college students are prone to depressive symptoms, anxiety symptoms, sleep disorders, and other problems. | ZHANG Yu Tong HUANG Tao ZHOU Fang HUANG Ao Di JI Xiao Qi HE Lu GENG Qiang WANG Jia MEI Can XU Yu Jia YANG Ze Long ZHAN Jian Bo CHENG Jing | 2022 | Biomedical and Environmental Sciences2022，35，7： | 1 |
| 3 | A Numerical Approach to Simulate Fiber Motion Trajectory in an Airflow Field in Compact Spinning with a Perforated Drum显示文摘 | Zhuan Yong Zou Long Di Cheng Zhi Hong Hua | 2010 | Textile Research Journal2010，，5： | 1 |
| 4 | A Rotor Unbalance Response Based Approach to the Identification of the Closed-Loop Stiffness and Damping Coefficients of Active Magnetic Bearings显示文摘 | Zhou Jin Di Long Cheng Changli | 2016 | Mechanical Systems and Signal Processing2016，6667，： | 1 |
| 5 | Identification and characterization of isocitrate dehydrogenase 1(IDH1)as a functional target of marine natural product grincamycin B显示文摘Grincamycins(GCNs)are a class of angucycline glycosides isolated from actinomycete Streptomyces strains that have potent antitumor activities,but their antitumor mechanisms remain unknown.In this study,we tried to identify the cellular target of grincamycin B(GCN B),one of most dominant and active secondary metabolites,using a combined strategy.We showed that GCN B-selective-induced apoptosis of human acute promyelocytic leukemia(APL)cell line NB4 through increase of ER stress and intracellular reactive oxygen species(ROS)accumulation.Using a strategy of combining phenotype,transcriptomics and protein microarray approaches,we identified that isocitrate dehydrogenase 1(IDH1)was the putative target of GCN B,and confirmed that GCNs were a subset of selective inhibitors targeting both wild-type and mutant IDH1 in vitro.It is well-known that IDH1 converts isocitrate to 2-oxoglutarate(2-OG),maintaining intracellular 2-OG homeostasis.IDH1 and its mutant as the target of GCN B were validated in NB4 cells and zebrafish model.Knockdown of IDH1 in NB4 cells caused the similar phenotype as GCN B treatment,and supplementation of N-acetylcysteine partially rescued the apoptosis caused by IDH1 interference in NB4 cells.In zebrafish model,GCN B effectively restored myeloid abnormality caused by overexpression of mutant IDH1(R132C).Taken together,we demonstrate that IDH1 is one of the antitumor targets of GCNs,suggesting wild-type IDH1 may be a potential target for hematological malignancies intervention in the future. | Zheng Wang Zeng-xia Li Wen-cao Zhao Hong-bo Huang Jia-qi Wang Hao Zhang Jun-yan Lu Rui-na Wang Wei Li Zhao Cheng Wen-long Xu Di Zhu Li-sha Zhou Wei Jiang Long Yu Jun-yan Liu Cheng Luo Heng Zhu Dan Ye Wei-jun Pan Jian-hua Ju Yong-jun Dang | 2021 | Acta Pharmacologica Sinica2021，42，5： | 0 |
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