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| 1 | Preliminary Investigation of the Clinical Significance of Detecting Circulating Tumor Cells Enriched from Lung Cancer Patients显示文摘 | Chi Wu Huaijie Hao Longyun Li Xiaoyun Zhou Zijian Guo Li Zhang Xiaotong Zhang Wei Zhong Huiqin Guo Ross Macrae Bremner Ping Lin | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 2 | Synthesis of a thin-layer MnO2 nanosheet-coated Fe3O4 nanocomposite as a magnetically separable photocatalyst显示文摘 | ZHANG Lishu LIAN Jianshe WU Longyun | 2014 | Langmuir2014，30，23： | 1 |
| 3 | Cerebrospinal Fluid Concentrations of Gefitinib in Patients With Lung Adenocarcinoma显示文摘 | Jing Zhao Minjiang Chen Wei Zhong Li Zhang Longyun Li Yi Xiao Ligong Nie Pei Hu Mengzhao Wang | 2012 | Clinical Lung Cancer2012，，： | 1 |
| 4 | LncRNA LIMT(LINC01089)contributes to sorafenib chemoresistance via regulation of miR-665 and epithelial to mesenchymal transition in hepatocellular carcinoma cells显示文摘Hepatocellular carcinoma(HCC)is one of the most malignant tumors worldwide and HCC patients often develop drug resisitene.Long non-coding RNAs(LncRNAs)are closely related to cell cycle,growth,development,differentiation,and apoptosis.Abnormally expressed lncRNAs have been proved to mediate drug resistance in tumor cells.However,the effect of LIMT on drug resistance has not been explored in HCC.In this study,we explored the effect of long non-coding RNA LIMT on drug resistance and its underlying mechanism in hepatocellular carcinoma(HCC).Our results showed that LncRNA LINC01089(LIMT)expression is downregulated in 78.57%(44/56)of 56 HCC tumor tissue samples.LIMT expression is also downregulated in HCC cells compared with that in normal liver LO2 cells.Inhibition of LIMT increases the resistance to sorafenib and promotes cell invasion via regulation of epithelial to mesenchymal transition(EMT)in HCC.StarBase V3.0 was used to predict the potential binding site of miR-665 in LIMT.Furthermore,miR-665 participates in sorafenib resistance and also regulates the level of EMT-related proteins in HCC cells.A rescue experiment demonstrated that silencing of LIMT eliminats the inhibitory effect of the miR-665 inhibitor on sorafenib resistance in HCC cells.Taken together,our findings revealed that downregulation of LIMT increases the resistance of HCC to sorafenib via miR-665 and EMT.Therefore,LIMT,which serves as a therapeutically effective target,will provide new hope for the treatment of HCC. | Jing Sun Xiaoxiao Zheng Baoming Wang Ying Cai Li Zheng Liqiang Hu Xuemei Lu Shangzhi Xie Xin Zhang Hao Liu Longyun Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 5 | Preliminary Investigation of the Clinical Significance of Detecting Circulating Tumor Cells Enriched from Lung Cancer Patients显示文摘 | Chi Wu Huaijie Hao Longyun Li Xiaoyun Zhou Zijian Guo Li Zhang Xiaotong Zhang Wei Zhong Huiqin Guo Ross Macrae Bremner Ping Lin | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 6 | High corn oil dietary intake improves health and longevity of aging mice显示文摘 | Hongwei Si Longyun Zhang Siqin Liu | 2014 | Experimental Gerontology2014，58，10： | 1 |
| 7 | Star pattern recognition method based on neural network显示文摘Star sensor is an avionics instrument used toprovide the absolute 3-axis attitude of a spacecraft by utiliz-ing star observations. The key function is to recognize theobserved stars by comparing them with the reference cata-logue. Autonomous star pattern recognition requires thatsimilar patterns can be distinguished from each other with a small training set. Therefore, a new method based on neural network technology is proposed and a recognition systemcontaining parallel backpropagation (BP) multi-subnets isdesigned. The simulation results show that the method per-forms much better than traditional algorithms and the pro-posed system can achieve both higher recognition accuracyand faster recognition speed. | LI Chunyan LI Ke ZHANG Longyun JIN Shengzhen ZU Jifeng | 2003 | Chinese Science Bulletin2003，48，18： | 0 |
| 8 | Investigation of mass transfer model of CO_(2) absorption with Rayleigh convection using multi-relaxation time lattice Boltzmann method显示文摘CO_(2) absorption into absorbents is a widely used method to reduce carbon emissions,in which the concentration gradient near the gas-liquid interface may induce Rayleigh convection(RC).Once RC occurs,the mass transfer rate will be significantly enhanced.Therefore,it is necessary to explore the mass transfer enhancement mechanism further and develop a penetration/surface divergence hybrid mass transfer model.In this study,we conduct research on the process of CO_(2) absorption into ethanol with RC.Firstly,we use a multi-relaxation time lattice Boltzmann method to simulate the absorption process and obtain the flow and concentration fields.And we also verify the reliability of the numerical simulation results by comparing with the experimental results.Then,we analyze the characteristics of non-uniform flow and concentration fields in RC.Moreover,we divide the near-interface region into diffusion-dominated and convection-dominated mass transfer zones by checking whether the horizontal average velocity is greater than 1.0×10^(-4) m·s^(-1).Furthermore,based on the differences in mass transfer mechanisms of the aforementioned two zones,we propose a penetration/surface divergence hybrid model to predict the instantaneous mass transfer coefficient.The prediction results demonstrate that the hybrid model can precisely predict the instantaneous mass transfer coefficient of the entire CO_(2) absorption process.Our proposed hybrid model provides a promising way to deal with the complex mass transfer problems with non-uniform flow and concentration fields. | Longyun Zheng Kai Guo Hongwei Cai Bo Zhang Hui Liu Chunjiang Liu | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 0 |
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