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| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 3 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 4 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 5 | Plastic rotation ca- pacity of high-strength concret beams 显示文摘 | Lopes S M R Bernardo L F A | 2003 | Materials and Structure/Materiaux et Constructions2003，36，225： | 1 |
| 6 | Adding protein context to the human protein -protein interaction network to reveal meaningful inter- actions显示文摘 | SCHAEFER M H LOPES T J S MAH N et at | 2013 | PLoS Comput Biol2013，9，10： | 1 |
| 7 | Lunar and solar triggering of earthquakes显示文摘 | Lopes R M C Malin S R C Mazzarella A | 1990 | Physics of the Earth and Planetary interiors1990，59，： | 1 |
| 8 | Ad- sorption of H2, CO2, CH4, CO, N2 and H20 in activa- ted carbon and zeolite for hydrogen production显示文摘 | LOPES F V S GRANDE C A RIBEIRO A M | 2009 | Sep- aration Science and Technology2009，，5： | 1 |
| 9 | Bio-oils upgrading for second generation biofuels显示文摘 | Graca I Lopes J M Cerqueira H S | | 0，，： | 1 |
| 10 | External validation of a classification for methylene blue magnification chromoendoscopy in premalignant gastric lesions显示文摘 | Miguel Areia Pedro Amaro Mário Dinis-Ribeiro Maria Augusta Cipriano Carol Marinho Altamiro Costa-Pereira Carlos Lopes Luís Moreira-Dias José Manuel Rom?ozinho Hermano Gouveia Diniz Freitas Maximino Correia Leit?o | 2008 | Gastrointestinal Endoscopy2008，，7： | 1 |
| 11 | Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novelnoninvasive treatment by SOD in transfersomes 显示文摘 | Simoes S I Delgado T C Lopes R M | 2005 | J Controlled Release2005，103，2： | 1 |
| 12 | Determination ofammonium in marine waters using a gas diffusion multicommutedflow injection system with in-line prevention of metal hydroxidesprecipitation显示文摘 | Oliveira S M Lopes T Toth I V | 2009 | J Environ Monit2009，11，22： | 1 |
| 13 | Seismic behavior of dual systems with column hinging显示文摘 | LOPES M S BENTO R | 2001 | Earthquake Spectra2001，17，4： | 1 |
| 14 | Analysis of EGFR overexpression,EGFR gene amplification and the EGFRvⅢ mutation in Portuguese high-grade gliomas显示文摘 | Viana M Lopes JM Little S | 2008 | Anticancer Res2008，28，： | 1 |
| 15 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers and Struc- tures2006，，84： | 1 |
| 16 | Geo- metrical Nonlinearities on the Static Analysis of Highly Flexible Steel Cable-stayed Bridges显示文摘 | FREIRE A M S NEGRAO J H O LOPES A V | 2006 | Com puters and Structures2006，84，3132： | 1 |
| 17 | Acid catalyzed alco- holysis of soybean oil 显示文摘 | Goff M J Bauer N S Lopes S | 2004 | J Am Oil Chem Soc2004，81，4： | 1 |
| 18 | Nitrogen source and water regime effects on durum wheat photosynthesis and stable carbon and nitrogen isotope composition显示文摘 | Lopes M S Arans J L | 2006 | Physiologia Plantamm2006，126，3： | 1 |
| 19 | The electrochemical oxidation of xylitol on Pt(Ⅲ) in acid medium显示文摘 | MATOS J P F PROENCA L LOPES M I S | 2004 | J Electroanal Chem2004，571，： | 1 |
| 20 | Conforma- tional preferences of a,a-trehalose in gas phase and aqueous solu- tion显示文摘 | Nunes S C C Lopes Jesus A J Joao Moreno M | 2010 | Carbohydrate Research2010，345，14： | 1 |
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