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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 4 | Govern- ment Ownership of Banks 显示文摘 | La Porta R Lopez - de - Silanes F Shleifer A | 2002 | Journal of Finance2002，57，1： | 1 |
| 5 | Corporate Ownership Around the Wurld 显示文摘 | La Port R Lopez - De - Silanes F Shleifer A | 1999 | the Journal of Finance1999，，54： | 1 |
| 6 | Investor Protection and Corporate Governance 显示文摘 | La Porta R Lopez - de - Silanes F Shleifer A Vishny R | 2000 | Journal of Financial Economics2000，58，： | 1 |
| 7 | Cognitive trajectories associated with b-amyloid deposition in the oldest- old without dementia显示文摘 | Snitz BE Weissfeld LA Lopez OL | 2013 | Neurology2013，80，15： | 1 |
| 8 | Fine-tuning of the piping model through small-scale,medium-scale and ijkdijk experiments 显示文摘 | SELLMEIJER J B LOPEZ de LA CRUZ J van BEEK V M KNOEFF J G | 2011 | European Journal of Environmental and Civil Engineering2011，15，8： | 1 |
| 9 | Investor protection and corporate governance 显示文摘 | La Port R Lopez - De - Silanes F Shleifer A Vishny R | 2000 | Journal of Financial Economics2000，58，： | 1 |
| 10 | Posterior alien hand syndrome after a right thalamic infarction显示文摘 | Lopez JM nazabal ER Magdalena LA | 2002 | J Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 11 | Estimating conjectural variations for electricity market models 显示文摘 | Lopez de Haro S Sanchez Martin P de la Hoz Ardiz J E | 2007 | European Journal of Operational Research2007，181，3： | 1 |
| 12 | Corporate Ownemhip around the World显示文摘 | La Porta Rafael Florence Lopez - De - Silanes An - drei Shlcifer | | 0，，02： | 1 |
| 13 | Corporate Ownership around the World 显示文摘 | La Porta R Lopez -de -Silanes F Shleifer A Vishny R W | 1999 | Journal of Finance1999，54，： | 1 |
| 14 | Investor protection and corporate valuation 显示文摘 | La Port R Lopez - De - Silanes F Shleifer A Vishny R | 2002 | Journal of Finance2002，57，3： | 1 |
| 15 | Legal Determinants of External Finance 显示文摘 | La Porta R Lopez - de - Silanes F Shleifer A Vishny R | 1997 | Journal of Finance1997，52，3： | 1 |
| 16 | Vascular endothelial growth factor administration in chronic myocardial ischemia显示文摘 | Harada K Friedman M Lopez JJ et la | 1996 | Am J Physiol1996，270，52： | 1 |
| 17 | Corporate ownership around the World显示文摘 | La Porta R Lopez de Silanes F Shleifer A | | 0，，02： | 1 |
| 18 | The window for clinical effectiveness of mass evacuation in a rat balloon model mimicking an intraparenchymatous hematoma显示文摘 | Lopez VE Hernandez LA Calandre L | 2000 | J Neurol Sci2000，74，： | 1 |
| 19 | The benefits of privatization : evidence from Mexico 显示文摘 | La Porta R Lopez - de - Silance F | 1999 | Quarterly Journal of Economics1999，，： | 1 |
| 20 | Law and finance显示文摘 | La Porta Rafael Lopez - de - Silanes Florencio Shleifer Andrei Vishny Robert W | 1998 | Journal of Political Economy1998，106，： | 1 |
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