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| 1 | New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review显示文摘In this paper review we describe benefits and disadvantages of the established methods of cartilage regeneration that seem to have a better long-term effectiveness.We illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineering, through mesenchymal stem cells and biomaterials,and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair procedures.Adult articular cartilage has low capacity to repair itself,and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, result-ing in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to implement clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubM ed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the wellknown tissue engineering methods for the treatment of knee osteoarthritis. | Giuseppe Musumeci Paola Castrogiovanni Rosalia Leonardi Francesca Maria Trovato Marta Anna Szychlinska Angelo Di Giunta Carla Loreto Sergio Castorina | 2014 | World Journal of Orthopedics2014，5，2： | 10 |
| 2 | Hepatocellular carcinoma and the risk of occupational exposure显示文摘Hepatocellular carcinoma(HCC)is the most common type of liver cancer.The main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and hemophilia.Occupational exposure to chemicals is another risk factor for HCC.Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent.This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. | Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta Bertino Mariano Malaguarnera Vito Emanuele Catania Isidoro Di Carlo Adriana Toro Emanuele Bertino Dario Mangano Gaetano Bertino | 2016 | World Journal of Hepatology2016，8，13： | 5 |
| 3 | Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms显示文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:'F'and'f'for Fok I,'B'and'b'for Bsm I,'A'and'a'for ApaI,and 'T'and't'for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. | Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci | 2017 | Cancer Biology & Medicine2017，14，2： | 5 |
| 4 | Paclobutrazol and Its Use in Fruit Production:A Review显示文摘There are documentary records referring to paclobutrazol(PBZ)as a growth bioregulator that inhibits the gibberellin synthesis and its application increases yields in fruit and vegetable crop productions.Its agronomic management includes it as an emerging technology to reduce vigour,promote flower induction and flower development in fruit trees with increased economic returns.Its use is banned in some countries because of concerns about residues that can cause harmful effects on the environment.Therefore,the aim of this article was to collect,analyse and summarise relevant information on the use of PBZ in fruit tree production and its possible risks to the environment.The results obtained indicated that the application of PBZ can be effective in solving some problems related to flowering if it is applied in the right amount and at the right time.However,it is necessary to elucidate the physiological processes with which it is associated and its response to be taken into account to increase yield.PBZ is currently used in fruit trees such as mango,lime,apple and guava,increasing their productivity.However,some studies have shown its residual effect on the environment.Therefore,PBZ is a viable strategy,because it presents a series of advantages in the production of fruit trees.However,it is vital to generate protocols that seek its regulation with a rational and sustainable approach. | Laura Raquel Orozco-Meléndez Ofelia Adriana Hernández-Rodríguez Oscar Cruz-Álvarez Loreto Robles-Hernández Graciela Dolores Avila-Quezada Esteban Sánchez Chavez DamiánAarón Porras-Flores Dámaris Leopoldina Ojeda-Barrios | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 5 | New findings showing how DNA methylation influences diseases显示文摘In 1975, Holliday and Pugh as well as Riggs independently hypothesized that DNA methylation in eukaryotes could act as a hereditary regulation mechanism that influences gene expression and cell differentiation. Interest in the study of epigenetic processes has been inspired by their reversibility as well as their potentially preventable or treatable consequences. Recently, we have begun to understand that the features of DNA methylation are not the same for all cells.Major differences have been found between differentiated cells and stem cells.Methylation influences various pathologies, and it is very important to improve the understanding of the pathogenic mechanisms. Epigenetic modifications may take place throughout life and have been related to cancer, brain aging, memory disturbances, changes in synaptic plasticity, and neurodegenerative diseases,such as Parkinson's disease and Huntington's disease. DNA methylation also has a very important role in tumor biology. Many oncogenes are activated by mutations in carcinogenesis. However, many genes with tumor-suppressor functions are 'silenced' by the methylation of CpG sites in some of their regions.Moreover, the role of epigenetic alterations has been demonstrated in neurological diseases. In neuronal precursors, many genes associated with development and differentiation are silenced by CpG methylation. In addition,recent studies show that DNA methylation can also influence diseases that do not appear to be related to the environment, such as IgA nephropathy, thus affecting,the expression of some genes involved in the T-cell receptor signaling. In conclusion, DNA methylation provides a whole series of fundamental information for the cell to regulate gene expression, including how and when the genes are read, and it does not depend on the DNA sequence. | Fabio Sallustio Loreto Gesualdo Anna Gallone | 2019 | World Journal of Biological Chemistry2019，10，1： | 2 |
| 6 | Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children显示文摘 | Martin Gotteland Monica Andrews Marcela Toledo Loreto Mu?oz Paola Caceres Alyerina Anziani Emma Wittig Hernan Speisky Gabriela Salazar | 2008 | Nutrition2008，，5： | 2 |
| 7 | 随钻声波测井新技术显示文摘工程师根据声波测井仪记录的声波资料以更高的安全系数提高钻井效率,优化完井方式。LWD声波测井仪是在上世纪90年代中期问世的,能够记录纵波资料,但不能记录所有地层的横波资料。新型LWD声波测井仪能记录以前无法得到的横渡资料,工程师正在利用横渡资料优化钻井作业,确定最佳钻进方向,识别具有更好完井特征的岩层。 | Jeff Alford Matt Blyth Ed Tollefsen John Crowe Julio Loreto Saeed Mohammed Vivian Pistre Adrian Rodriguez-Herrera | 2013 | 国外测井技术2013，，2： | 2 |
| 8 | Effects of whole-body vibration exercise on the endocrine system of healthy men显示文摘 | Di Loreto C Ranchelli A Lucidi P | 2004 | J Endocrinol Invest2004，27，： | 1 |
| 9 | Collagenase-3 (MMP-13) is expressed in periapical lesions: an immunohistochemical study International显示文摘 | Leonardi R Caltabiano R Loreto C | 2005 | Endodontie2005，38，5： | 1 |
| 10 | Coagulation and cancer:impli- cation for diagnosis and management显示文摘 | Loreto MF De Martinis M Corsi MP | 2000 | Pathol Oncol Res2000，6，： | 1 |
| 11 | Statistical physics of social dynamics显示文摘 | Castellano C Fortunato S Loreto V | 2009 | Rev Mod Phys2009，81，2： | 1 |
| 12 | A High Index of Suspicion: The Key to an Early Diagnosis of Wilson’s Disease in Childhood显示文摘 | Icíar Sánchez-Albisua Teresa Garde Loreto Hierro Carmen Camarena Esteban Frauca Angela de la Vega María Carmen Díaz Javier Larrauri Paloma Jara | 1999 | Journal of Pediatric Gastroenterology & Nutrition1999，，2： | 1 |
| 13 | Genetic networks responsive to low-intensity pulsed ultrasound in human lymphoma U937 cells显示文摘 | Yoshiaki Tabuchi Ichiro Takasaki Qing-Li Zhao Shigehito Wada Takeshi Hori Loreto B. Feril Katsuro Tachibana Takaharu Nomura Takashi Kondo | 2008 | Cancer Letters2008，，2： | 1 |
| 14 | Semiotic dynamics and collaborative tagging显示文摘 | Loreto V Pietroner L | 2007 | Proceedings of the National Academy of Sciences of the United States of America2007，104，： | 1 |
| 15 | Influence of environmental factors and air composition on the emission of alpha-pinene from Quercus ilex leaves显示文摘 | LORETO F CICCIOLI P CECINATO A | 1996 | Plant Physiology1996，110，1： | 1 |
| 16 | Long QT,alteration of calcium-phosphate product,prevalence of ventricular arrhythmias and sudden death in peritoneal dialysis patients:a Holter study显示文摘 | Di Loreto P Ronco C Vescovo G | 2012 | Italian J Med2012，6，2： | 1 |
| 17 | Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis -infected human epithelial cells in vitro显示文摘 | Yurika Ikeda-Dantsuji Loreto B. Feril Katsuro Tachibana Koichi Ogawa Hitomi Endo Yoshimi Harada Ryo Suzuki Kazuo Maruyama | 2010 | Ultrasonics - Sonochemistry2010，，1： | 1 |
| 18 | Statistical physics of social dynamics显示文摘 | Castellano C Fortunato S Loreto V | | 0，，： | 1 |
| 19 | Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin显示文摘 | Musumeci G Lo Furno D Loreto C | | 0，，： | 1 |
| 20 | Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling,vimentin-positive cells and cell death显示文摘 | Loreto C Musumeci G Castorina A | | 0，，02： | 1 |
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