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| 1 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 2 | Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier显示文摘Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)mice.To investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 minutes.Either LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 post-insult.After AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation end-products.After intervention with LBP,the above changes were significantly reduced.Remarkably,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also observed.These results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH insult.This study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval No.CULTRA-#1664-08). | Xue-Song Mi Qian Feng Amy Cheuk Yin Lo Raymond Chuen-Chung Chang Sookja Kim Chung Kwok-Fai So | 2020 | Neural Regeneration Research2020，15，12： | 8 |
| 3 | Molecular basis of von Hippel-Lindau syndrome in Chinese patients显示文摘背景 Von Hippel-Lindau ( VHL )症候群是预先安排的正染色体的主导的家庭癌症症候群影响个人到在用南部的汉语的 VHL 的基因基础大部分是的各种各样的 organs.The 的多重瘤 unknown.In 这研究,我们在九无关的南部的中国 families.Methods 描绘了 VHL 的变化光谱有 VHL 的临床的特征的九 probands ,二征兆并且八个无征状的家庭成员在这 study.Prenatal | SIU Wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert Yan-wo | 2011 | Chinese Medical Journal2011，，2： | 6 |
| 4 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 5 | Pre-B-cell-colony- enhancing factor is critically involved in thromhin-induced lung endothelial cell barrier dysregulation显示文摘 | Ye SO Zhang LO Adyshev D | 2005 | Microvasc Res2005，70，3： | 1 |
| 6 | Rapamycin-FKBP inhibits cell cycle rogulators of proliferation in vascular smooth muscle cells 显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，3： | 1 |
| 7 | Rapamycin-FKB-Pinhibits cell cycle regulators of proliferation in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 8 | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells 显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 9 | Rapamycin -FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 10 | Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | Winnie K.W. So Gene Marsh W.M. Ling F.Y. Leung Joe C.K. Lo Maggie Yeung George K.H. Li | 2009 | European Journal of Oncology Nursing2009，，1： | 1 |
| 11 | Rapamycin-FKBP inhibits cell cycle regulators of prolife ration in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，3： | 1 |
| 12 | Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells显示文摘 | Mi XS Zhang X Feng Q Lo AC Chung SK So KF | 2012 | Invest Ophthalmol Vis Sci2012，53，8： | 1 |
| 13 | Photodynamic inactivation of Candida albicans by BAM-SiPc显示文摘 | SO C W P W TSANG P C LO | 2009 | Mycoses2009，2，4： | 1 |
| 14 | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells 显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 15 | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 16 | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，： | 1 |
| 17 | Is albumin therapy worthwhile in surgery for colorectal cancer 显示文摘 | Nilsson E I amke LO Liljedahl SO | 1980 | Acta Chir Scand1980，146，8： | 1 |
| 18 | Rapamycin-FKBP in- hibits cell cycle regulators of proliferation in vascular smooth muscle cells 显示文摘 | MARX SO JAYARAMAN T GO LO | 1995 | Circ Res1995，76，3： | 1 |
| 19 | Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells显示文摘 | Marx SO Jayaraman T Go LO | 1995 | Circ Res1995，76，3： | 1 |
| 20 | Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy显示文摘 | So WK Marsh G Ling WM Leung FY Lo JC Yeung M Li GK | 2010 | Eur J On- col Nurs2010，14，1： | 1 |
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