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| 1 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 2 | Vibrational properties of silicene and germanene显示文摘 | Emilio Scalise Michel Houssa Geoffrey Pourtois B. van den Broek Valery Afanas'ev andAndr Stesmans | 2013 | Nano Research2013，6，1： | 5 |
| 3 | Topological to trivial insulating phase transition in stanene显示文摘stanene 的电子性质, graphene 的 Sn 对应物理论上用第一原则的模拟被学习。对一个 out-of-plane 电场或由量监禁效果导致的小绝缘阶段转变拓扑被预言。结果加亮潜力在门电压使用 stanene nanoribbons 控制了无驱散的基于纺纱的设备并且被用来将最小的 nanoribbon 宽度放为如此的设备,它典型地是约 5 nm。 | Michel Houssa Bas van den Broek Konstantina Iordanidou Anh Khoa Augustin Lu Geoffrey Pourtois Jean-Pierre Locquet Valery Afanas'ev Andre Stesmans | 2016 | Nano Research2016，9，3： | 2 |
| 4 | Role for adrenal venous sampling in primary aldosteronism显示文摘 | William F. Young Anthony W. Stanson Geoffrey B. Thompson Clive S. Grant David R. Farley Jon A. van Heerden | 2004 | Surgery2004，，6： | 1 |
| 5 | Environmental Supply Chain Management: Using Life Cycle Assessment to Structure Supply Chains 显示文摘 | Hagelaar Geoffrey J L F der Vorst Jack G A J Van | 2002 | International Food and Agribusiness Management Review2002，，4： | 1 |
| 6 | Platform Envelopment显示文摘 | Thomas Eisenmann Geoffrey Parker Marshall Van Alstyne | 2011 | Strategic Management Journal2011，32，12： | 1 |
| 7 | NASH is an lnflammatory Disorder: Pathogenic, Prognostic and Therapeutic Imp- lications显示文摘 | Geoffrey C Farrell Derrick van Rooyen Lay Gan | 2012 | Gut and Liver2012，6，2： | 1 |
| 8 | Papillary Thyroid Carcinoma Managed at the Mayo Clinic during Six Decades (1940–1999): Temporal Trends in Initial Therapy and Long-term Outcome in 2444 Consecutively Treated Patients显示文摘 | Ian D. Hay Geoffrey B. Thompson Clive S. Grant Eric J. Bergstralh Catherine E. Dvorak Colum A. Gorman Megan S. Maurer Bryan McIver Brian P. Mullan Ann L. Oberg Claudia C. Powell Jon A. van Heerden John R. Goellner | 2002 | World Journal of Surgery2002，，8： | 1 |
| 9 | Windpressure distribution influence on natural ventilation for differentincidences and environment densities显示文摘 | Geoffrey van Moeseke Elisabeth Gratia Sigrid Reiter | 2005 | Energy and Buildings2005，37，8： | 1 |
| 10 | Environmental Supply Chain Management:Using Life Cycle Assessment to Structure Supply Chains 显示文摘 | Geoffrey J L F Hagelaar Jack G A J van der Vorst | 2002 | International Food and Agribusiness Management Review2002，5，4： | 1 |
| 11 | Platform Envelopment显示文摘 | Thomas Eisenmann Geoffrey Parker Marshall Van Alstyne | 2011 | Strategic Management Jour- nal2011，，32： | 1 |
| 12 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 13 | Wind Pressure Distribution Influence on Natural Ventilation for Different Incidences and Environment Densities显示文摘 | Geoffrey van Moeseke Elisabeth Gratia Sigrid Reiter | 2005 | Energy and Buildings2005，37，8： | 1 |
| 14 | Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation显示文摘 | Eric van der Veer Zengxuan Nong Caroline O’Neil Brad Urquhart David Freeman J Geoffrey Pickering | 2005 | Circulation Research2005，，1： | 1 |
| 15 | The Role of Subacromial Decompression in Patients Undergoing Arthroscopic Repair of Full-Thickness Tears of the Rotator Cuff: A Systematic Review and Meta-analysis显示文摘 | Jaskarndip Chahal Nathan Mall Peter B. MacDonald Geoffrey Van Thiel Brian J. Cole Anthony A. Romeo Nikhil N. Verma | 2012 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2012，，5： | 1 |
| 16 | Wind pres-sure distribution influence on natural ventilation for different incidences and environment densities显示文摘 | Geoffrey van Moeseke Elisabeth Gratia Sigrid Reiter | 2005 | Energy and Buildings2005，37，8： | 1 |
| 17 | Periprosthetic fractures in total hip arthroplasty 显示文摘 | Geoffrey J Van Flandern | 2005 | Orthopedics2005，28，： | 1 |
| 18 | Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart显示文摘 | Geoffrey G. Hesketh Manish H. Shah Victoria L. Halperin Carol A. Cooke Fadi G. Akar Timothy E. Yen David A. Kass Carolyn E. Machamer Jennifer E. Van Eyk Gordon F. Tomaselli | 2010 | Circulation Research2010，，6： | 1 |
| 19 | Intradermal Versus Intramuscular Hepatitis B Vaccination in Hemodialysis Patients: A Prospective Open-Label Randomized Controlled Trial in Nonresponders to Primary Vaccination显示文摘 | Katherine A. Barraclough Kathryn J. Wiggins Carmel M. Hawley Carolyn L. van Eps David W. Mudge David W. Johnson Michael Whitby Sally Carpenter E. Geoffrey Playford | 2009 | American Journal of Kidney Diseases2009，，1： | 1 |
| 20 | Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome<!-- Doctopic: GMD -->显示文摘 | Derrick M. Van Rooyen Lay T. Gan Matthew M. Yeh W. Geoffrey Haigh Claire Z. Larter George Ioannou Narci C. Teoh Geoffrey C. Farrell | 2013 | Journal of Hepatology2013，，1： | 1 |
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