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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 3 | tRNAscanSE: A program for improved detection of Transfer RNA genes in genomic sequence显示文摘 | Lowe T M Eddy S R | 1997 | Nucleic Acids Research1997，25，5： | 1 |
| 4 | Anessentiat role for A adeninemet hylation in bacterial virulence显示文摘 | Heithoff D M Sinsheimer R L Low D A | 2000 | Trans R Soc Lond B Biol Sci2000，355，1397： | 1 |
| 5 | Rationalizing the Activities of Diverse Cholecystokinin 2 Receptor Antagonists Using Molecular Field Points显示文摘 | Low C M R Vinter J G | 2008 | J Med Chem2008，51，3： | 1 |
| 6 | An Exploration of the Technical Feasibility of Achieving CO2 Emission Reductions in Excess of 60% Within the UK Housing Stock by the Year 2050显示文摘 | Johnston D Lowe R Bell M | 2005 | Energy Policy2005，83，： | 1 |
| 7 | Folate receptor-mediated targeting of liposomal drugs to cancer cells显示文摘 | STEPHENSON S M LOW P S LEE R J | 2004 | Methods Enzymol2004，387，： | 1 |
| 8 | Intra-prostatic uriuary reflux:an aetological factor in abacterial prostatitis显示文摘 | KIRBY R S LOWE D BULTITUDE M I | 1982 | Urol1982，54，6： | 1 |
| 9 | Outcome assessment of double-J stents during extracorporeal shockwave lithotripsy of small solitary renal calculi显示文摘 | LOW R K STOLLER M L IRBY P | 1996 | Endourol1996，10，： | 1 |
| 10 | Relation between extent of coronary artery disease and blood viscosity显示文摘 | LOWE G D DRUMMOND M M LORIMER A R | 1980 | Br Med J1980，280，3： | 1 |
| 11 | MR staging of primary colorectal carcinoma: comparison with surgical and histopathologic findings 显示文摘 | Low RN McCue M Barone R | 2003 | Abdom Imaging2003，28，6： | 1 |
| 12 | Monitoring acoustic wave propagation in buried cast iron water pipes显示文摘 | Long R Vine K Lowe M J S | | Review of Progress in Quantitative Nondestructive Evaluation0，200，20： | 1 |
| 13 | tRNAscan-SE: A program for improved detection of transfer RNA genes in genomic sequence显示文摘 | Lowe T M Eddy S R | 1997 | Nucleic Acids Research1997，25，5： | 1 |
| 14 | Factors controlling the thermal stability of aluminum titanate ceramics in vacuum 显示文摘 | LOW I M LAWRENCE D SMITH R I | 2005 | J Am Ceram Soc2005，88，： | 1 |
| 15 | An Fscherichia coli strain for use nitrate analyses显示文摘 | Lowe R H Gillespie M | 1975 | J Agric Food Chem1975，23，： | 1 |
| 16 | New Lignan Glucosides from Stemmadenia minima 显示文摘 | Achenbach H Lowe M Waibel R | 1992 | Planta Med1992，58，： | 1 |
| 17 | Early salt stress effects on the differential expression of vacuolar H -ATPase genes in roots and leaves of mesembryanthemum erystallinum 显示文摘 | LOW R ROCKED B KRISH M | 1996 | Plant Physiol1996，110，1： | 1 |
| 18 | Coordination of pro- duction scheduling and delivery problems with heterogeneous fleet 显示文摘 | Low C Chang C M Li R K | 2014 | International Journal of Production Economics2014，153，1： | 1 |
| 19 | tRNAscan-SE:a program for improved detection of transfer RNA genes in genomic sequence显示文摘 | Lowe T M Eddy S R | | 0，，05： | 1 |
| 20 | Distal symmetric polyneuropathy: A definition for clinical research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation显示文摘 | J D. England G S. Gronseth G Franklin R G. Miller A K. Asbury G T. Carter J A. Cohen M A. Fisher J F. Howard L J. Kinsella N Latov R A. Lewis P A. Low A J. Sumner | 2005 | Neurology2005，，2： | 1 |
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