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| 1 | Renin-angiotensin system in the kidney: What is new?显示文摘The renin-angiotensin system(RAS)has been known for more than a century as a cascade that regulates body fluid balance and blood pressure.AngiotensinⅡ(AngⅡ)has many functions in different tissues;however it is on the kidney that this peptide exerts its main functions.New enzymes,alternative routes for AngⅡformation or even active AngⅡ-derived peptides have now been described acting on AngⅡAT1or AT2receptors,or in receptors which have recently been cloned,such as Mas and AT4.Another interesting observation was that old members of the RAS,such as angiotensin converting enzyme(ACE),renin and prorenin,well known by its enzymatic activity,can also activate intracellular signaling pathways,acting as an outside-in signal transduction molecule or on the renin/(Pro)renin receptor.Moreover,the endocrine RAS,now is also known to have paracrine,autocrine and intracrine action ondifferent tissues,expressing necessary components for local AngⅡformation.This in situ formation,especially in the kidney,increases AngⅡlevels to regulate blood pressure and renal functions.These discoveries,such as the ACE2/Ang-(1-7)/Mas axis and its antangonistic effect rather than classical deleterious AngⅡeffects,improves the development of new drugs for treating hypertension and cardiovascular diseases. | Fernanda M Ferr?o Lucienne S Lara Jennifer Lowe | 2014 | World Journal of Nephrology2014，3，3： | 5 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 4 | The reflection of guided waves from circumferential notches in pipes 显示文摘 | Alleyne D N Lowe M J S Cawley P | 1998 | Trans ASME J of Appl Mech1998，65，： | 2 |
| 5 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | LOWE S E THEODOROU M K TRINCI A P J | 1985 | Journal of General Microbiology1985，131，： | 1 |
| 6 | Coronary in-stent restenosis:current status and future strategies显示文摘 | LOWE H C OESTERLE S N KHACHIGIAN L M | 2002 | J Am Coll Cardiol2002，39，2： | 1 |
| 7 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen S M Low D E Henry B | 2003 | N Engl J Med2003，348，20： | 1 |
| 8 | Guided waves in curved pipes显示文摘 | DEMMA A CAWLEY P LOWE M J S | 2002 | Review of Progress in Quantitative Nondestructive Evaluation2002，21，： | 1 |
| 9 | tRNAscanSE: A program for improved detection of Transfer RNA genes in genomic sequence显示文摘 | Lowe T M Eddy S R | 1997 | Nucleic Acids Research1997，25，5： | 1 |
| 10 | Fundamental impor- tance of Na+-Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node显示文摘 | Sanders L Rakovic S Lowe M | 2006 | J Physiol2006，571，3： | 1 |
| 11 | The sport psychology program of the USA women's national volleyball team显示文摘 | GIPSON M MCKENZIE T LOWE S | 1989 | Sport Psychol1989，3，： | 1 |
| 12 | Non-destructive testing of rock bolts using guided ultrasonic waves显示文摘 | Beard M D Lowe M J S | 2003 | Intl Journal of Rock Mechanics & Mining Science2003，40，： | 1 |
| 13 | Defect detection in pipes using guided waves显示文摘 | LOWE M J S ALLEYNE D N CAWLEY P | 1998 | Ultrasonics1998，36，： | 1 |
| 14 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Lowe S E Theodoron M K Trinci A P J | 1985 | J Gen Microbiol1985，131，： | 1 |
| 15 | Optimistic Synchronization in HLA-based Distributed Simulation 显示文摘 | X Wang S J Turner M Y H Low | 2005 | Simulation (S0037-5497)2005，81，4： | 1 |
| 16 | Non-destructive testing ofrock bolts using guided ultrasonic waves显示文摘 | BEARD MD LOWE M J S | 2003 | InternationalJournal of Rock Mechanics and Mining Sciences & Ge-omechanics Abstracts2003，40，4： | 1 |
| 17 | Myocardial infarction in young people with normal coronary arteries显示文摘 | Restieanx N J Low C J S | 1998 | Heart1998，79，5： | 1 |
| 18 | Pediatric ethmoidectomy显示文摘 | PRANSKY S M LOW W S | 1996 | Otolaryngol Clio North Am1996，29，1： | 1 |
| 19 | Coronary instent restenosis:current status and future strategies显示文摘 | Lowe H C Oesterle S N Khachigian L M | 2002 | J Am Coll Cardiol2002，39，21： | 1 |
| 20 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen S M Low D E Henry B | 2003 | N Engl J Med2003，13，： | 1 |
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