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| 1 | Severe COVID-19 patients exhibit an ILC2 NKG2D^(+) population in their impaired ILC compartment显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the current COVID-19 disease pandemic.In some patients,the symptoms are mild,and a fraction of SARS-CoV-2-infected individuals develop severe illness with a high fatality rate due to lung damage and acute respiratory distress syndrome.1 Innate lymphoid cells(ILCs)are a recently identified type of effector immune cells that rapidly sense environmental stimuli and participate in early immune responses by promptly secreting large amounts of cytokines.2 The ILC2 subpopulation was shown to mediate Type 2 responses and to recruit eosinophils during viral lung infections upon the release of alarmins(e.g.,IL-33)by damaged epithelial cells.3,4,5 ILC2s were also shown to participate in the termination of inflammatory responses and tissue repair by amphiregulin secretion.In addition,ILC2s are critical in the early phases of allergic lung inflammation,including that induced by the protease allergen papain.6 Based on the essential function of the papain-like protease PLpro in regulating SARS-CoV-27(Fig.1a)and the severe lung damage caused by this virus,we sought to investigate the potential involvement of ILC2s in immune responses to COVID-19. | Alejandra Gomez-Cadena Laurie Spehner Marie Kroemer Myriam Ben Khelil Kevin Bouiller Grégory Verdeil Sara Trabanelli Christophe Borg Romain Loyon Camilla Jandus | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Chilling injury in plants显示文摘 | LOYONS J M | | Plant Physical0，324，： | 1 |
| 3 | Chilling injury in plants显示文摘 | Loyons J M | 1973 | Plant Physical1973，24，2： | 1 |
| 4 | Chilling injury in plants 显示文摘 | LOYONS J M | 1973 | Plant Physical1973，24，： | 1 |
| 5 | Chilling injury in plants显示文摘 | Loyons J M | 1973 | Plant Physical1973，24，3： | 1 |
| 6 | Gaseous Emissions (NH3,N20,CH4 and CO2)from the aerobic treatment of piggery slurry-comparison with a conventional storage system显示文摘 | L Loyon F Guiziou F Beline | 2007 | Biosystems Engineering2007，97，： | 1 |
| 7 | opinion leadership in a computer mediated environment 显示文摘 | Loyons B | 2005 | Journal of Consumer Behavior2005，4，5： | 1 |
| 8 | Gaseous emissions(NH3, N20, CH4 and CO2) from the aerobic treatment of piggery slurry: Comparison with a conventional storage system显示文摘 | Loyon L Guiziou F Beline F | 2007 | Bio-systems Engineering2007，97，： | 1 |
| 9 | Air and gas drilling manmual显示文摘 | W C LOYONS | 1983 | New York:Gulf PublishingCo1983，，： | 1 |
| 10 | Gaseous Emissions (NH3,N2O,CH4 and CO2) from the aerobic treatment of piggery slurry-Comparison with a conventional storage system显示文摘 | Loyon L Guiziou F Beline F | | 0，，04： | 1 |
| 11 | CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery显示文摘CD226 has been reported to participate in the rescue of CD8^(+)T cell dysfunction.In this study,we aimed to assess the prognostic value of CD226 in tumor-infiltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical surgery.TILs from 43 metastases were isolated and analyzed ex vivo usingflow cytometry.CD155 and CD3 levels in the tumor microenvironment were assessed by immunohistochemistry.Exploration and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression datasets.CD226 expression contributes to the definition of the immune context in CRC liver metastases and primary tumors.CD226 on CD8^(+)T cells was not specifically coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver metastases.Multivariate Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of CD226.Gene expression analysis in a validation dataset confirmed the prognostic value of CD226 in CRC liver metastases but not in primary tumors.Downregulation of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 treatment.Overall,CD226 expression on liver metastasis-infiltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery. | Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre Elodie Renaude Elodie Klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe Borg Marie Kroemer | 2023 | Cellular & Molecular Immunology2023，20，4： | 0 |
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