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| 1 | Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey显示文摘AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer dyspepsia.METHODS: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme immunoassay.RESULTS: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western countries.CONCLUSION: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals. | Ender Serin Uur Yilmaz Ganiye Künefeci Birol zer Yüksel Gümürdülü Mustafa Gülü Fazilet Kayaseluk Sedat Boyaciolu | 2003 | World Journal of Gastroenterology2003，9，4： | 10 |
| 2 | PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress显示文摘One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detailed mechanism is less clear.In this study,the expressing plasmids of wild-type PrP (PrP-PG5)and various PrP mutants containing 0(PrP-PG0),9(PrP-PG9)and 12(PrP-PG12)octarepeats were generated and PrP proteins were expressed both in E.coli and in mammalian cells.Protein aggregation and formation of carbonyl groups were clearly seen in the recombinant PrPs expressed from E.coli after treatment of H2O2.MTT and trypan blue staining assays revealed that the cells expressing the mutated PrPs within octarepeats are less viable than the cells expressing wild-type PrP.Statistically significant high levels of intracellular free radicals and low levels of glutathione peroxidase were observed in the cells transfected with plasmids containing deleted or inserted octarepeats.Remarkably more productions of carbonyl groups were detected in the cells expressing PrPs with deleted and inserted octarepeats after exposing to H2O2.Furthermore,cells expressing wild-type PrP showed stronger resistant activity to the challenge of H2O2 at certain extent than the mutated PrPs and mock. These data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation.Loss of its protective function against oxidative stress may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases. | AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China | 2008 | Science China(Life Sciences)2008，51，7： | 3 |
| 3 | Pelvic pain : overlooked and underdiagnosed gynecologic conditions 显示文摘 | Kuligowska E Deeds L 3rd Lu K 3 rd | 2005 | Radiographics2005，25，1： | 1 |
| 4 | Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease 显示文摘 | Lund RD Wang S Lu B | 2007 | Stem Cells2007，25，3： | 1 |
| 5 | Ceils isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease显示文摘 | Lund RD Wang S Lu B | 2007 | Stem Cells2007，25，3： | 1 |
| 6 | Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus显示文摘 | Lu YF Kandel ER Hawkins RD | 1999 | J Neurosci1999，19，10： | 1 |
| 7 | Comparison of two tension - band fixation materials and techniques in transverse patella fractures: a biomechanical study显示文摘 | Rahalais RD Burger E Lu Y | 2008 | Orthopedics2008，31，2： | 1 |
| 8 | CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56^+ T cells显示文摘 | Lopez RD Waller EK Lu PH | 2001 | Cancer Immunol Immunother2001，49，12： | 1 |
| 9 | Comparisonof two tension-band fixation materials andtechniques in transverse patella fractures:abiomechanical study显示文摘 | Rabalais RD Burger E Lu Y et a 1 | 2008 | Orthopedics2008，31，2： | 1 |
| 10 | Cd58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+Tcell显示文摘 | Lopez RD Waller EK Lu PH | | 0，，12： | 1 |
| 11 | Molecular comparison of Giardia lamblia isolates显示文摘 | Lu SQ Baruch AC Adam RD | 1998 | Int J Parasitol1998，28，9： | 1 |
| 12 | Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease显示文摘 | Lund RD Wang S Lu B | 2007 | Stem Cells2007，25，： | 1 |
| 13 | Comparison of two tension-band fixation materials and techniques in transverse patella fractures: a biomechanical study显示文摘 | Rabalais RD Burger E Lu Y | 2008 | Orthopedics2008，31，2： | 1 |
| 14 | Cells isolated from um- bilical cord tissue rescue photoreceptors and visual func- tions in a rodent model of retinal disease 显示文摘 | Lund RD Wang SM Lu Bin | 2007 | Stem Cells2007，25，3： | 1 |
| 15 | CD58/LFA-3 and IL-12 pro- vided by activated monocytes are critical in the in vitro expansion of CD56A- T cells显示文摘 | Lopez RD Waller EK Lu PH | 2001 | Cancer Immunol Immunother2001，49，12： | 1 |
| 16 | Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus显示文摘 | Lu YF Kandel ER Hawkins RD | 1999 | J neurosci1999，19，10： | 1 |
| 17 | CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells显示文摘 | Lopez RD Wailer EK Lu P H | 2001 | Cancer Immunol Immunother2001，49，12： | 1 |
| 18 | CD58/(LAF-3) and IL12 provided by activated monocytes are critical in the vitro expansion of CD56 + T cells显示文摘 | Lopez RD Waller EK Lu PH | 2001 | Cancer Immunol Immunother2001，49，12： | 1 |
| 19 | CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56 + T cells显示文摘 | Lopez RD Waller EK Lu PH | | 0，，12： | 1 |
| 20 | Duodenoscopy in treatment acute gallstone pancreatitis显示文摘 | Zhou MQ Li NP Lu RD | 2002 | Hepatobilliary Pancreat Dis Int2002，1，4： | 1 |
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