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| 1 | Overexpression of the tonoplast aquaporin AtTIP5;1 conferred tolerance to boron toxicity in Arabidopsis显示文摘Boron (B) toxicity to plants is responsible for low crop productivity in many regions of the world. Here we report a novel and effective means to alleviate the B toxicity to plants under high B circumstance. Functional characterization of AtTIP5;1, an aquaporin gene, re-vealed that overexpression of AtTIP5;1 (OxAtTIP5;1) in Arabidopsis significantly increased its tolerance to high B toxicity. Compared to wild-type plants, OxAtTIP5;1 plants exhibited longer hypocotyls, accelerated development, increased silique production under high B treatments. GUS staining and quantitative RT-PCR (qRT-PCR) results demonstrated that the expression of AtTIP5;1 was induced by high B concentration treatment. Subcellular localization analysis revealed that the AtTIP5;1-GFP fusion protein was localized on the tonoplast membrane, which was consistent with the prediction based on bioinformatics. Taken together, our results suggest that AtTIP5;1 is in-volved in B transport pathway possibly via vacuolar compartmentation for B, and that overexpression of AtTIP5;1 in plants may provide an effective way to overcome the problem resulting from high B concentration toxicity. | Yongqi Pang, Lijuan Li, Fei Ren, Pingli Lu, Pengcheng Wei, Jinghui Cai, Lingguo Xin, Juan Zhang, Jia Chen, Xuechen Wang State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China | 2010 | Journal of Genetics and Genomics2010，37，6： | 11 |
| 2 | Ricin-B-lectin enhances microsporidia Nosema bombycis infection in BmN cells from silkworm Bombyx mori显示文摘 | Han Liu Mingqian Li Shunfeng Cai Xinyi He Yongqi Shao Xingmeng Lu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 6 |
| 3 | Emission inventories of NOx from commercial energy consumption in china,1995-1998显示文摘 | Tian Hezhong Lu Yongqi | 2002 | Environ Sci Technol2002，36，： | 1 |
| 4 | In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy显示文摘The therapeutic efficiency of active targeting nanoparticulate drug delivery systems(nano-DDS)is highly compromised by the plasma proteins adsorption on nanoparticles(NPs)surface,which significantly hinders cell membrane receptors to recognize the designed ligands,and provokes the off-target toxicity and rapid clearance of NPs in vivo.Herein,we report a novel dihydroartemisinin(DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E(apoE)on the NPs surface.The apoE-anchored corona is able to prolong PLGA-PEG2000-DHA(PPD)NPs circulation capability in blood,facilitate NPs accumulating in tumor cells by the passive enhanced permeability and retention(EPR)effect and low-density lipoprotein receptor(LDLr)-mediated target transport,and ultimately improve the in vivo antitumor activity.Our findings demonstrate that the strategy of in situ regulated apoE-enriched corona ensures NPs an efficient LDLr-mediated tumor-homing chemotherapy. | Zhenbao Li Jiaojiao Zhu Yongqi Wang Mei Zhou Dan Li Shunzhe Zheng LiLi Yin Cong Luo Huicong Zhang Lu Zhong Wei Li JianWang Shuangying Gui Biao Cai Yongjun Wang Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，4： | 1 |
| 5 | Emission inventories of NOx from commercial consumption in China,1995-1998显示文摘 | Hao Jiming Tian Hezhong Lu Yongqi | 2002 | Environ Sci Technol2002，36，4： | 1 |
| 6 | Impacts of Kuwait oil Fires on the Mount Qornolangma Region显示文摘 | Gao Dengyi Lu J Weixiu Gao Yongqi | 1996 | Adv Atrnos Sci1996，13，2： | 1 |
| 7 | Analysis of errors & calibration method for manufacturing multilevel diffractive optical element by ion etching显示文摘 | Fu Yongqi Lu Zhenwu Ma Yueying | 1998 | SPIE1998，3357，： | 1 |
| 8 | Three-dimensional WO3 nanostruetures on carbon paper:photoelectroehemical property and visible light driven photoeatalysis 显示文摘 | Zhang Xianghui Lu Xihong Shen Yongqi | 2011 | Chemical Communications2011，47，20： | 1 |
| 9 | Behavior of Gas-Solid flow in the Downcomer of a Circulating Fluidized Bed Reactor with a V-valve显示文摘 | Yongqi Lu Fengming Wang | 1997 | Powder Technology1997，91，： | 1 |
| 10 | Emission inventories of NOx from commercial energy consumption in China, 1995~1998 显示文摘 | Hao Jiming Tian Hezhong Lu Yongqi | 2002 | Environmental Science & Technology2002，36，4： | 1 |
| 11 | Preparation of Ag+/TiO2 Composite Coating Film for Preservation of Nanfeng Citrus显示文摘Using tetrabutyl titanate as the precursor,silver nitrate as the load agent,silver-doped titanium dioxide coating film was prepared by sol-gel method.Three agent samples were characterized by X-ray diffraction( XRD) analysis to investigate the crystal structure,which confirmed a synergistic antibacterial effect.The antibacterial and preservative effects of silver-doped titanium dioxide coating film on Nanfeng citrus were investigated preliminarily. Nutritional indicators of ripe Nanfeng citrus before and after preservation were detected to investigate the preservative properties of silver-doped titanium dioxide coating film and compare the effects of different components of composite coating film. The results showed that Ag^+/TiO_2 composite coating film exhibited high antibacterial and preservative effects on Nanfeng citrus under visible light illumination condition. | Xiaoyi LONG Jinyin CHEN Fenju LAI Tianyi LU Yongqi FU Shaolin JIANG Xiaoqiang YU | 2016 | Agricultural Biotechnology2016，5，3： | 1 |
| 12 | Anthropogenic nitrogen oxides Emissions in china in the period1990- 1998显示文摘 | Tian Hezhong Lu Yongqi | 2001 | Abstracts of Papers of American Chemistry Society2001，221，11： | 1 |
| 13 | impacts of the Kuwait Oil Fires on the Mount Qomolangma Region显示文摘 | Gao Dengyi Lu Weixiu Gao Yongqi | 1996 | Adv Atmos Sci1996，13，： | 1 |
| 14 | Extended research on software hybrid testing combining reliability and directed testing显示文摘The software reliability testing has many disadvantages in practice,such as high complexity of constructing operational profiles and poor fault detection efficiency.Oppositely,the directed testing with a high fault detection rate is incapable of estimating reliability quantificationally.To solve this problem,a hybrid testing combining reliability and directed testing as well as a reliability model based on the order statistic(OS) model were presented by Mitchell.An extended research on Mitchell's work is proposed.Firstly,the most proper distribution of the fault's failure rate which tends to be lognormal is suggested,and a detailed form of the OS model based on lognormal and the corresponding parameter estimation method are proposed,respectively.Secondly,an implementing framework for the hybrid testing is proposed.Finally,the hybrid testing and the OS model are applied on a real website system.The experimental results indicate:the hybrid testing has more efficient fault detection power and lower testing cost than the reliability testing;compared with three traditional software reliability growth models,the OS model has a best or pretty estimation or prediction power for each data set;and for the failure data set collected from hybrid testing,the OS model also achieves an acceptable estimation result. | Haifeng Li Yongqi Zhang Minyan Lu | 2011 | Journal of Systems Engineering and Electronics2011，22，5： | 1 |
| 15 | Layer-by-layer enriching active Ni-N_(3)C sites in nickel-nitrogen-carbon electrocatalysts for enhanced CO_(2)-to-CO reduction显示文摘Transition metal and nitrogen co-doped carbons(M-N-C)have proven to be promising catalysts for CO_(2)electroreduction into co because of the high activity and selectivity.Effective enrichment of the active transition metal coordinated nitrogen sites is desirable but is challenging for a practical volumetric productivity.Herein,we report four kinds of model electrocatalysts to unveil this issue,which include the NC structures with surface N-functionalities,Ni-N-CI with one layer of surface Ni-NsC sites,NC@Ni-N-CI with surface N-functionalities and underneath Ni-N3C sites as well as Ni-N-C_II with doubled surface Ni-NsC sites.The X-ray absorption spectroscopy indicates the coordination configuration of Ni-NsC.For NC catalysts,when N-doping level increased from 3.5 at%to 8.4 at%,the CO partial current density increased from below 0.1 mA/cm^(2)to 3 mA/cm^(2).Introducing one layer of Ni-N_(3)C onto the NC structures leads to a 54 times higher CO partial current density than that of NC,in the meantime the FE_(CO) is 66 times higher.Furthermore,doubling the density of surface Ni-N_(3)C sites by a layer-by-layer method doubles the CO partial current density Gco,indicating its potential to achieve a high density of active coordinated sites and current densities. | Yongqi Ren Ruopeng Chang Xu Hua Junjie Guo Guangping Hao Anhui Lu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 16 | Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions显示文摘Drug repurposing or repositioning has been well-known to refer to the therapeutic applications of a drug for another indication other than it was originally approved for.Repurposing non-oncology small-molecule drugs has been increasingly becoming an attractive approach to improve cancer therapy,with potentially lower overall costs and shorter timelines.Several non-oncology drugs approved by FDA have been recently reported to treat different types of human cancers,with the aid of some new emerging technologies,such as omics sequencing and artificial intelligence to overcome the bottleneck of drug repurposing.Therefore,in this review,we focus on summarizing the therapeutic potential of non-oncology drugs,including cardiovascular drugs,microbiological drugs,small-molecule antibiotics,anti-viral drugs,anti-inflammatory drugs,antineurodegenerative drugs,antipsychotic drugs,antidepressants,and other drugs in human cancers.We also discuss their novel potential targets and relevant signaling pathways of these old non-oncology drugs in cancer therapies.Taken together,these inspiring findings will shed new light on repurposing more non-oncology small-molecule drugs with their intricate molecular mechanisms for future cancer drug discovery. | Leilei Fu Wenke Jin Jiahui Zhang Lingjuan Zhu Jia Lu Yongqi Zhen Lan Zhang Liang Ouyang Bo Liu Haiyang Yu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 17 | PxSy nanoparticles encapsulated in graphene as highly reversible cathode for sodium ion batteries显示文摘Herein,phosphorus-mediated sulfur nanoparticles encapsulated in reduced graphene oxide nanosheets(P-SrGO-T)were successfully synthesized as the cathode for sodium ion battery by a ball milling and the following thermal treatment.A series of covalent bonds,such as P–S,C–S–C,C–O–P and C–S–P,are formed in this process,which are in favor of fixing the sulfur and suppressing the parasitic shuttle effect of polysulfide.Benefiting from the graphene sheets and these covalent bonds,a high reversible capacity of 637.4 m Ah/g was achieved in P-SrGO-T after 100 cycles at the current density of 0.2 A/g.In addition,P-SrGO-T also delivers a high-rate capacity(330.7 m Ah/g at 5 A/g)attributing to low charge transfer resistance and faster ion diffusion kinetic.This work pushes the progress forward in developing phosphosulfide cathode for sodium ion batteries. | Ting Wang Zhixiong Huang Donghuang Wang Jiqi Wu Junjie Lu Zihan Jin Shaojun Shi Yongqi Zhang | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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