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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 4 | Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant Chemotherapy显示文摘 | Henry Bismuth René Adam Fran?is Lévi Christian Farabos Fabio Waechter Denis Castaing Pietro Majno Luc Engerran | 1996 | Annals of Surgery1996，，4： | 2 |
| 5 | Evaluation of a new, rapid,and quantitative D-Dimer test in patients with suspected pulmonary embolism显示文摘 | Emmanuel O Christophe L Luc B | 1998 | Am J Pespir Crit Care Med1998，158，1： | 1 |
| 6 | Esthesioneuroepitheliome offactif显示文摘 | Berger L Luc RL | 1924 | Bull Cancer(Paris)1924，13，2： | 1 |
| 7 | Firm size and inventive activity: the evidence reconsidered 显示文摘 | SOETE LUC L G | 1979 | European Economic Review1979，，： | 1 |
| 8 | Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice显示文摘 | Luc JW Vander L Christopher L | 2000 | Nature2000，407，： | 1 |
| 9 | Firm size and inventive activity : The evidencereconsidered 显示文摘 | SOETE LUC L G | 1979 | European Economic Review1979，，4： | 1 |
| 10 | Absorption of a mixture of volatile organic compounds(VOCs) in aqueous solutions of soluble cutting oil显示文摘 | FRANK L LUC M JEAN-CLAUDE R | 2008 | Bioresource Technology2008，99，6： | 1 |
| 11 | Firm size and inventive activity: the evi-dence reconsidered 显示文摘 | SOETE LUC L G | 1979 | European Economic Review1979，，2： | 1 |
| 12 | 128 case of myasthenia gravis treated with huperzine A 显示文摘 | CHENG Y S LUC Z YING Z L | 1956 | Chin J New Drugs Clin Rem1956，5，4： | 1 |
| 13 | Multiply scattered aerosol lidar returns: inversion method and coMParison with in situ measurements 显示文摘 | Luc R Bissonnettle Daniel L Hutt | 1995 | APPLIED OPTICS1995，34，30： | 1 |
| 14 | Complex Ownership Structures and Corporate Va- luations显示文摘 | Luc L Ross L | 2008 | Review of Financial Studies2008，21，2： | 1 |
| 15 | Effect of low central venous pressure and phlebotomy on blood product transfusion requirements during liver transplantation 显示文摘 | LUC M SERGE L | 2006 | Liver Transplantation2006，12，1： | 1 |
| 16 | Firm size and inventive activity: the evidence reconsidered 显示文摘 | Soete Luc L G | 1979 | European Economic Review1979，12，4： | 1 |
| 17 | An integrated MELD model including serum sodium &nd &ge improves the prediction of esriy mortslity in p&tients with cirrhosis显示文摘 | Luc& A Angerm&yr B Bertolini G et &l | 2007 | Liver Tr&nsplant2007，13，11： | 1 |
| 18 | Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive im- pairment criteria defined according to a population based study显示文摘 | Hine A Luc L Jean-Franois D | 2004 | Dement Geriatr Cognitive Disorder2004，18，： | 1 |
| 19 | Heavy metal distribution in some French forest soils:evidence for atmospheric contamination显示文摘 | Hemandez L Probst A Luc Probst J | 2003 | The Science of the Total Environment2003，312，： | 1 |
| 20 | L'esthesioneuroneuroepitheliome olfactif显示文摘 | Berger L Luc G Richard D | 1924 | Bull Assoc Franc Etude1924，13，： | 1 |
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