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| 1 | Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men显示文摘We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's infertility.Data from 189 in fertile men were an a lyzed.Semen analysis,serum hormones,and sperm DNA fragmentation(SDF)were obtained.Smoking status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+MD),and heavy drinker(+HD).Descriptive statistics and logistic regression models were applied.Among all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,respectively.In addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+MD and+HD,respectively.Regarding concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),respectively.Similarly,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/abstaining.When concomitant,+S/+D status has an even greater detrimental effect on semen parameters. | Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Filippo Pederzoli Walter Cazzaniga Francesco Chierigo Federico Deho Emanuele Montanari Francesco Montorsi Andrea Salonia | 2019 | Asian Journal of Andrology2019，21，5： | 6 |
| 2 | L.ong-term recovery of normal sexual function in lesticular cancer survivors显示文摘阴囊的癌症(TC ) 是在在生活的第三和第四十年之间的人的最普通的稳固的癌症。由于成功的治疗途径, TC 幸存者(TCS ) 有长寿预期,但是与众多的潜在的长期的 sequelae,包括性机能障碍。我们调查了长期的正常的预言者在 TCS 的性功能(SF ) 恢复。Sociodemographic,医药,并且 psychometric 数据在 143 白种人欧洲人 TCS 被分析,在一个单个机构经历了 orchiectomy。健康重要的 comorbidities 与 Charlson Comorbidity 索引(CCI ) 被获得。病人们完成了可勃起的功能(IIEF ) 的国际索引。统计模型测试了在预言者之间的协会(包括在外科,身体团索引, CCI,和辅助治疗的年龄:放射疗法[ RT ],化疗[ CT ], CT 由 retroperitoneal 淋巴节点解剖列在后面[ RPLND ]并且 RPLND 独自一个)并且正常 SF 的长期的恢复(定义同样IIEF可勃起的功能[ EF ] 26 ,并且性欲望[ SD ],交际满足[]高潮的功能[],并且全面满足[ OS ]在上面的 tertiles 的域分数)。在 86 个月的吝啬的后续, 35 (25.5%) TCS 有可勃起的机能障碍(编辑) ,(11.2%) 与 16 经历 EF 恢复的中部的时间是的严重编辑在 CT, RT,和 RPLND 以后的 60, 60,和 70 个月分别地。仅仅辅助的 RT 作为正常 EF 的 nonrecovery 的一个独立预言者出现了(HR:0.55, P= 0.01 ) 。加 RPLND 或 RPLND 的既不辅助 CT 也不 CT 显著地独自损害了正常勃起的恢复。辅助治疗没总体上与正常的性的损害恢复被联系,认为 IIEF-SD, -OF,-IS, 和 OS 是领域。 | Paolo Capogrosso Luca Boeri Matteo Ferrari Eugenio Ventimiglia Giovanni La Croce Umberto Capitanio Alberto Briganti Rocco Damiano Francesco Montorsi Andrea Salonia | 2016 | Asian Journal of Andrology2016，18，1： | 1 |
| 3 | Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction:outcomes of a tertiary referral center and predictors of early prosthetic infection显示文摘We aimed to evaluate ten-year outcomes of penile prosthesis(PP)implantation for the treatment of erectile dysfunction and to assess predictors of early prosthetic infection(EPI).We identified 549 men who underwent 576 PP placements between 2008 and 2018.Univariate and multivariate analyses were used to identify potential predictors of EPI.An EPI predictive nomogram was developed.Thirty-five(6.1%)cases of EPI were recorded with an explant rate of 3.1%.In terms of satisfaction,82.0%of the patients defined themselves as“satisfied,”while partner’s satisfaction was 88.3%.Diabetes(P=0.012),longer operative time(P=0.032),and reinterventions(P=0.048)were associated with EPI risk,while postoperative ciprofloxacin was inversely associated with EPI(P=0.014).Rifampin/gentamicin-coated 3-piece inflatable PP(r/g-c 3IPP)showed a higher EPI risk(P=0.019).Multivariate analyses showed a two-fold higher risk of EPI in diabetic patients,redo surgeries,or when a r/g-c 3IPP was used(all P<0.03).We showed that diabetes,longer operative time,and secondary surgeries were the risk factors for EPI.Postoperative ciprofloxacin was associated with a reduced risk of EPI,while r/g-c 3IPP had higher EPI rates without an increased risk of PP explant.After further validation,the proposed nomogram could be a useful tool for the preoperative counseling of PP implantation. | Franco Palmisano Luca Boeri Riccardo Ievoli Josvany Sánchez-Curbelo Matteo Giulio Spinelli Andrea Gregori Antonio Maria Granata Eduard Ruiz-Castane Emanuele Montanari Joaquim Sarquella-Geli | 2022 | Asian Journal of Andrology2022，24，1： | 1 |
| 4 | Substances of abuse consumption among patients seeking medical help for uro-andrological purposes:a sociobehavioral survey in the real-life scenario显示文摘Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility status,erectile function,and ejaculation.We assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological purposes.Data from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed.A complete medical and sexual history was collected for each patient.Smoking,alcohol,and SoA consumption were investigated.Descriptive statistics was used to describe the whole cohort.The primary motivations for their evaluation were lower urinary tract symptoms(LUTS),erectile dysfunction(ED),and infertility in 1912(25.7%),2944(39.5%),and 2591(34.8%)men,respectively.Previous use of SoA was reported by 378(5.1%)men,and 190(2.6%)individuals were current users.Patients seeking medical attention for infertility were more frequently current SoA users(107;4.1%)than men with ED(66;2.2%)and LUTS(17;0.9%)(both P<0.001).Current users of SoA were younger than those with past or no SoA history(P<0.001).Current SoA users were more frequently smokers(P<0.001)and alcohol consumers(P<0.001)than those with a previous history or those who had never tried SoA.In conclusion,approximately 3%of men seeking medical attention for uro-andrological purposes were current SoA consumers.Infertile men reported a higher use of SoA than those with ED or LUTS.Current SoA users were younger and more frequently concomitant smokers and alcohol consumers compared to those who did or had never used SoA. | Federico Belladelli Luca Boeri Paolo Capogrosso Walter Cazzaniga Eugenio Ventimiglia Luigi Candela Edoardo Pozzi Andrea Baudo Massimo Alfano Costantino Abbate Francesco Montorsi Andrea Salonia | 2021 | Asian Journal of Andrology2021，23，5： | 0 |
| 5 | Testicular volume in infertile versus fertile white-European men: a case-control investigation in the real-life setting显示文摘Testicular volume(TV)is considered a good clinical marker of hormonal and spermatogenic function.Accurate reference values for TV measures in infertile and fertile men are lacking.We aimed to assess references values for TV in white-European infertile men and fertile controls.We analyzed clinical and laboratory data from 1940(95.0%)infertile men and 102(5.0%)fertile controls.Groups were matched by age using propensity score weighting.TV was assessed using a Prader orchidometer(PO).Circulating hormones and semen parameters were investigated in every male.Descriptive statistics,Spearman's correlation,and logistic regression models tested potential associations between PO-estimated TV values and clinical variables.Receiver operating characteristic(ROC)curves were used to find TV value cutoffs for oligoasthenoteratozoospermia(OAT)and nonobstructive azoospermia(NOA)status in infertile men.The median testicular volume was smaller in infertile than that of fertile men(15.0 ml vs 22.5 ml;P<0.001).TV positively correlated with total testosterone,sperm concentration,and progressive sperm motility(all P≤0.001)in infertile men.At multivariable logistic regression analysis,infertile status(P<0.001)and the presence of left varicocele(P<0.001)were associated with TV<15 ml.Testicular volume thresholds of 15 ml and 12 ml had a good predictive ability for detecting OAT and NOA status,respectively.In conclusion,infertile men have smaller testicular volume than fertile controls.TV positively correlated with total testosterone,sperm concentration,and progressive motility in infertile men,which was not the case in the age-matched fertile counterparts. | Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Walter Cazzaniga Edoardo Pozzi Federico Belladelli Filippo Pederzoli Massimo Alfano Costantino Abbate Emanuele Montanari Luca Valsecchi Enrico Papaleo Paola Vigano Patrizia Rovere-Querini Suks Minhas Francesco Montorsi Andrea Salonia | 2021 | Asian Journal of Andrology2021，23，5： | 0 |
| 6 | Metabolic syndrome in White-European men presenting for secondary couple's infertility: an investigation of the clinical and reproductive burden显示文摘我们试图与第二等的不孕在人在繁殖功能上决定新陈代谢的症候群(MetS ) 的影响,从研究人员收到了相对小的注意的一个条件。完全人口统计,临床,并且从 167 个连续的第二等的不肥沃的人的实验室数据被分析。健康重要的 comorbidities 与 Charlson Comorbidity 索引被获得(CCI;分类 0 对 1 对 2 或更高) 。NCEP-ATP III 标准被用来定义 MetS。精液分析值基于 2010 世界健康组织被估计() 引用标准。描述的统计和逻辑回归模型测试了在精液参数和临床的特征和 MetS 之间的协会。MetS 在 20 被发现(12%) 167 个人。有 MetS 的病人更老(P < 0.001 ) 并且有更大的 BMI (P < 0.001 ) 与那些相比没有 MetS。MetS 病人有全部的睾丸激素的底层(P = 0.001 ) ,性荷尔蒙绑定血球素, inhibin B,和 anti-M ??? 獮吗?? | Eugenio Ventimiglia Paolo Capogrosso Alessandro Serino Luca Boeri Michele Colicchia Giovanni La Croce Roberta Scano Enrico Papaleo Rocco Damiano Francesco Montorsi Andrea Salonia | 2017 | Asian Journal of Andrology2017，19，3： | 0 |
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