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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | 伴炎性肌纤维母细胞肿瘤样特征的去分化脂肪肉瘤显示文摘 | Lucas D R Shukla A Thomas D G 李岩(摘译 ) 张仁亚(审校) | 2010 | 临床与实验病理学杂志2010，26，5： | 6 |
| 3 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 4 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 5 | The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches显示文摘 | Antonella De Luca Monica R Maiello Amelia D’Alessio Maria Pergameno Nicola Normanno | 2012 | Expert Opinion on Therapeutic Targets2012，，2： | 2 |
| 6 | Antioxidant response to NaCI stress in sah-tolerant and sahsensitive cultivars of cotton显示文摘 | Gossett D R Millhollon E P Lucas M C | 1994 | Crop Sci1994，34，： | 1 |
| 7 | A Study of Current Logic Design Prac- tices in the Automotive Manufacturing Industry显示文摘 | Lucas M R Ilbury D M | 2003 | International Journal of Human-computer Studies2003，59，5： | 1 |
| 8 | Subjective well-be- ing:Three decades of progress 显示文摘 | Diener E d Suh E M Lucas R | 1999 | Psychological Bulle- tin1999，125，2： | 1 |
| 9 | Feature depth observation 显示文摘 | A D Luca G Oriolo P R Giordano | 2008 | International Journal of Robotic Research2008，27，10： | 1 |
| 10 | Screening of virulence- associated genes as a molecular typing method for characteriza- tion of Streptococcus suis isolates recovered from wild boars and pigs显示文摘 | Veronica S R Jose F G Lucas D | 2016 | Vet J2016，209，： | 1 |
| 11 | The Toxic Intensity of Industrial Production: Global Patterns, Trends, and Trade Policy 显示文摘 | Hettige H Lucas R E B Wheeler D | 1992 | American Economic Review1992，82，2： | 1 |
| 12 | From trimethylvinylsilane to ZrC-SiC hybrid materials 显示文摘 | PIZON D LUCAS R CHEHAIDI S | 2011 | J Eur Ceram Soc2011，31，14： | 1 |
| 13 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 14 | Oxida- tive stress induced by zere-valent iron nanoparticles and Fe(lI) in human bronchial epithelial cells 显示文摘 | KEENAN C R GOTH-GOLDSTEIN R LUCAS D | 2009 | Environmental Science and Technology2009，43，12： | 1 |
| 15 | Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women显示文摘 | Lucas E A Wild R D Hammond L J | 2002 | J Clin Endocr Metab2002，87，4： | 1 |
| 16 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 17 | The toxic intensity of industrial production: Global patterns,trends and trade policy 显示文摘 | Hettige H Lucas R E B Wheeler D | 1992 | American Economic Review1992，82，2： | 1 |
| 18 | Polycyclic aromatic hydrocarbons assessment in the sediments of the Porto Torres Harbor (Northern Sardinia,Italy)显示文摘 | Luca G D Furesi A Leardi R | | 0，，1： | 1 |
| 19 | Adhesive joints at high and low temperatures using similar and dissimilar adherends and dual adhesives 显示文摘 | Lucas F M da Silva Adams R D | 2007 | International Journal of Adhesion & Adhesives2007，27，： | 1 |
| 20 | Reversible optical transcription of supramolecular chirality into molecular chirality 显示文摘 | de Jong J J D Lucas L N Kellogg R M | 2004 | Science2004，304，： | 1 |
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