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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Late reopening of an occluded infarct related artery improves left ventricular function and long term clinical outcome显示文摘 | Piscione F Galasso G De Luca G | 2005 | Heart2005，91，5： | 1 |
| 3 | Transformation of maltose into prebiotic isomahooligosaccharides by a novel &-glucosidase from Xantophyllomyces dendrorhous 显示文摘 | Luca F A Dolores M Aranzazu G | 2007 | Process Biochemistry2007，42，： | 1 |
| 4 | Screening of virulence- associated genes as a molecular typing method for characteriza- tion of Streptococcus suis isolates recovered from wild boars and pigs显示文摘 | Veronica S R Jose F G Lucas D | 2016 | Vet J2016，209，： | 1 |
| 5 | Early glyco- protein lib-Ilia inhibitors in primary angioplasty (EGYPT) cooperation : an individual patient data meta- analysis 显示文摘 | de LUCA G GIBSON C M BELLANDI F | 2008 | Heart2008，94，： | 1 |
| 6 | Poly ( ethylene-co-vinylacetate) ( EVA) as wax in hibit or of a Brazili an crude oil: oilviscosity, pour point and phase behavior of organic solutions 显示文摘 | Machado A L C Lucas E F Gonzalez G | 2001 | Journal of Petroleum Science and Engineering2001，32，234： | 1 |
| 7 | Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk显示文摘 | Sibilia V Pagani F Rindi G Lattuada N Rapetti D De Luca V et al | 2008 | Br J Pharmacol2008，154，： | 1 |
| 8 | Assessment of polymeric flocculants in oily water systems显示文摘 | Gonzalez G Lucas E F | 2005 | Colloid Polym Sci2005，283，： | 1 |
| 9 | The effects of tertiary wastewater treatment on the prevalence of antimicrobial re- sistant bacteria显示文摘 | Luca G Danilo M A Lo F W | 2002 | Water Research2002，36，： | 1 |
| 10 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 11 | Reversal of cardiac and large artery structural abnormalities induced by long-term antihypertensive treatment with trandolapril显示文摘 | De Luca N Rosiello G Lamenza F | 1992 | Am J Cardiol1992，70，： | 1 |
| 12 | Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty显示文摘 | De Luca G Suryapranata H Zijlstra F | | 0，，： | 1 |
| 13 | Poly (ethylene-co-vinyl acetate)(EVA)as wax inhibitor of a Brazilian crude oil:Oil viscosity, pour point and phase behavior of organic solutions显示文摘 | MACHADO A L C LUCAS E F GONZáLEZ G | 2001 | Journal of Petroleum Science and Engineering2001，32，2： | 1 |
| 14 | Early glycoprotein Ⅱb-Ⅲa inhibitors in primary angioplasty-abciximab long-term results (EGYPTALT) cooperation:individual patient's data meta-analysis显示文摘 | De Luca G Bellandi F Huber K | | 0，，12： | 1 |
| 15 | At the end of a two-year follow-up elevated TSH levels normalize or remain unchanged in most the children with subclinical hypothyroidism 显示文摘 | De Luca F Wasniewska M Zirilli G | 2010 | Ital J Pediatr2010，36，： | 1 |
| 16 | Gene therapy of inherited skin adhesion disorders:a critical overview显示文摘 | De Luca M Pellegrini G Mavilio F | 2009 | Br J Dermatol2009，161，1： | 1 |
| 17 | Thrombus aspi ration in primary percutaneous coronary intervention in high risk patients with ST elevation myocardial infarction: a real world registry显示文摘 | Mangiacapra F Wijns W De Luca G etal | 2010 | Catheter Cardiovasc Interv2010，76，： | 1 |
| 18 | Statin-like principles of Bergamot fruit ( Citrus bergamia) : isolation of 3-hydroxymethylglutaryl flavonoid glycosides 显示文摘 | DI DONNA L DE LUCA G MAZZOTFI F | 2009 | J Nat Prod2009，72，7： | 1 |
| 19 | Determination ofillicit drugs in seized materials : role of sampling and analysisin estimationof measurement uncertaonty 显示文摘 | Luca Z Giampietro F Maria G | 2011 | Forensic Science International2011，208，10： | 1 |
| 20 | Recipient-derived HPA-1a antibodies: a cause of prolonged thrombocytopenia af- ter unrelated donor stem cell transplantation 显示文摘 | Lucas G Culliford S Green F | 2010 | Transfusion2010，50，2： | 1 |
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