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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Repetitive-control-base selfcommissioning procedure for inverter nonidealities compensation 显示文摘 | SILVERIO B LUCA P MAURO Z | 2008 | IEEE Transaction on Industry Applications2008，44，15： | 1 |
| 3 | Direct ampholyte-free liquid-phase isoelectric peptide focusing: application to the human serum proteome显示文摘 | XIAO Z CONRADS T P LUCAS D A | 2004 | Electrophoresis2004，25，1： | 1 |
| 4 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 5 | Tellurium-based far-infrared transmitting glasses显示文摘 | YANG Z LUCAS P | 2009 | Journal of the American Ceramic Society2009，92，12： | 1 |
| 6 | Sequence stratigraphy based on high-resolution seismic profiles in the Late Pleistocene and Holoeene deposits of the Venice area显示文摘 | Massimo Z Luca B Giuliano B | 2008 | Marine Geology2008，253，3： | 1 |
| 7 | Characterization and pathogenicity of Pythium species isolated from turfgrass with symptoms of root and crown rot in North Cqrolina显示文摘 | Abad Z G Shew H D Lucas L T | 1994 | Phytopathology1994，84，： | 1 |
| 8 | Determination ofillicit drugs in seized materials : role of sampling and analysisin estimationof measurement uncertaonty 显示文摘 | Luca Z Giampietro F Maria G | 2011 | Forensic Science International2011，208，10： | 1 |
| 9 | Clinical and biochemical effects of coenzyme Q10,vitamin E,and selenium supplementation to psoriasis patients显示文摘 | Kharaeva Z Gostova E De Luca C | 2009 | Applied Nutritional Investigation2009，25，3： | 1 |
| 10 | Identifying microRNA targets in different gene regions显示文摘 | Xu W San Lucas A Wang Z | 2014 | BMC Bioinformatics2014，15，7： | 1 |
| 11 | Characterization and pathogenicity of Pythium species isolated from turfgrass with symptoms of root and crown rot in North Carolina显示文摘 | Abad Z G Shew H D Lucas L T | 1994 | Phytopathology1994，84，： | 1 |
| 12 | Effects of intrauterine food restriction and long-term dietary supple mentation with L-arginine on age-related changes in renal function and structure of rats 显示文摘 | Gil F Z Lucas S R Gomes G N | 2005 | Pediatr Res2005，57，51： | 1 |
| 13 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 14 | Common drive in motor units of a syn- ergistic muscle pair显示文摘 | DE LUCA C J ERIM Z | 2002 | J Neurophysiol2002，87，： | 1 |
| 15 | Uranium extraction from aqueous solution using dried and pyrolyzed tea and coffee wastes 显示文摘 | ALY Z LUCA V | 2013 | Journal of Radioanalytical Nuclear Chemistry2013，295，2： | 1 |
| 16 | The environmental 'risky' region:identifying land degradation processes through integration of socio-economic and ecological indicators in a multivariate regionalization model显示文摘 | Luca S Marco Z | 2009 | Environmental Management2009，44，： | 1 |
| 17 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S Li R Zhang Z Li L Gu X Fan W Lucas W J Wang X Xie B Ni P | | 0，，： | 1 |
| 18 | The genome of the cucumber,Cucumis sativus L显示文摘 | Huang S W Li R Q Zhang Z H Li L Gu X F Fan W Lucas W J Wang X W Xie B Y Ni P X Ren Y Zhu H M Li J Lin K Jin W W Fei Z J Li G C Staub J B Kilian A van der Vossen E A G Wu Y Guo J He J Jia Z Q Ren Y Tian G Lu Y Ruan J Qian W Wang M W Huang Q F Li B Xuan Z L | | 0，，12： | 1 |
| 19 | Character sums and congruences with n! 显示文摘 | Garaev M Z Luca F Shparlinski I E | 2004 | Trans Amer Math Soc2004，356，12： | 1 |
| 20 | Sums and congruences with factorials显示文摘 | Garaev M Z Luca F Shparlinski I E | 2005 | J Reine Angew Math2005，584，3： | 1 |
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