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| 1 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 2 | Accuracy accessment of sattelite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEI V D | 1994 | Potogramatic Engineering & Remote Sensing1994，60，4： | 1 |
| 3 | Accuracy assessment of satellite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEL V D | 1994 | Photogrammetric Engineering & Remote Sensing1994，60，4： | 1 |
| 4 | Utilization of metabolic scope in relation to feeding and activity by individual and grouped zebrafish, Brachydanio rerio ( Hamilton-Buchanan ) 显示文摘 | Lucas M C Priede I G | 1992 | J Fish Biol1992，41，： | 1 |
| 5 | A new therapeutic strategy for electrical cardioversion of atrial fibrillation 显示文摘 | de Luca I Sorino M Del Salvatore B | 2001 | Italian Heart Journal2001，2，： | 1 |
| 6 | The phenotype of soluble starch synthase Ⅳ defective mutants of Arabidopsis thaliana suggests a novel function of elongation enzymes in the control of starch granule formation显示文摘 | Roldan I Wattebled F Lucas M | 2007 | The Plant Journal2007，49，3： | 1 |
| 7 | Syntyesis of 13X Zeolite from Calcined Kaolins and Sodium Silicate for Use in Detergents显示文摘 | De Lucas A Uguina M A Coviln I | 1992 | Ind Eng Chem Res1992，31，9： | 1 |
| 8 | Accuracy assessment of satellite derived land-cover data: a review 显示文摘 | Lucas I F JFrans J M Wel V D | 1994 | Photogrammetric Engineering and Remote Sensing1994，60，4： | 1 |
| 9 | Accuracy assessment of satellite derived land-cover data: review 显示文摘 | Lucas I F J Frans J M Wel V D | 1994 | Photogram-metric Engineering & Remote Sensing1994，60，4： | 1 |
| 10 | Atyp;eal Presentations and Rare Metastatic Sites of Renal Cell Careinoma 显示文摘 | Petros S I inda M Luca C | 2011 | Journal of Medical Case Reports2011，5，429： | 1 |
| 11 | Energy Metabolism of eggs during embryogenesis in balanus balanoides显示文摘 | Lucas M I Crisp D J | 1987 | J Mar Biol Ass U K1987，67，： | 1 |
| 12 | Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis显示文摘 | Vergne I Chua J Lee HH Lucas M Belisle J Deretic V | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 13 | Effect of angiotensin-converting enzyme inhibition on infarct collagen deposition and remodelling during healing after transmural canine myocardial infarction显示文摘 | Lucas A Khan M I | 1997 | Can J Cardiol1997，13，7： | 1 |
| 14 | Histone acetylation regulates the time of replication origin firing 显示文摘 | Vogelauer M Rubbi L Lucas I | 2002 | Mol Cell2002，10，5： | 1 |
| 15 | Accuracy assessment of satellite derived land cover data: a review显示文摘 | Lucas I F J Frans J M Wel V D | 1994 | Photogrammetric Engineering and Remote Sensing1994，60，4： | 1 |
| 16 | Accuracy assessment of satellite derived land-cover data: a review 显示文摘 | Lucas I F J Frans J M | 1994 | Photogrammetric Engineering & Remote Sensing1994，60，4： | 1 |
| 17 | HLA-DR in cou- ples associated with preeclampsia: background and updating by DNA sequencing显示文摘 | de Luca Brunori I Battini L Simonelli M | 2003 | J Reprod Immunol2003，59，2： | 1 |
| 18 | Accuracy assessment of satellite derived land-cover data:A review photogram metric 显示文摘 | Lucas I F J FRANS J M | 1994 | Engineering & Remote Sensing1994，60，4： | 1 |
| 19 | cDNA cloning, sequence comparison, and developmental expression of Xenopus rael显示文摘 | J M Lucas I Nikolic M D Hens | 2002 | Mechanisms of Development2002，115，： | 1 |
| 20 | Preparation and characterization of Ca1-xCexMnO3 perovskite electrodes 显示文摘 | LUCAS C EIROA I NUNES M R | 2009 | Journal of Solid State Electrochemistry2009，13，6： | 1 |
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