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您的检索式：作者名="Luchen Sun"
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| 1 | A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy显示文摘Currently the main treatment of acute myeloid leukemia(AML)is chemotherapy combining hematopoietic stem cell transplantation.However,the unbearable side effect of chemotherapy and the high risk of life-threatening infections and disease relapse following hematopoietic stem cell transplantation restrict its application in clinical practice.Thus,there is an urgent need to develop alternative therapeutic tactics with significant efficacy and attenuated adverse effects.Here,we revealed that umbilical cord-derived mesenchymal stem cells(UC-MSC)efficiently induced AML cell differentiation by shuttling the neutrophil elastase(NE)-packaged extracellular vesicles(EVs)into AML cells.Interestingly,the generation and release of NE-packaged EVs could be dramatically increased by vitamin D receptor(VDR)activation in UC-MSC.Chemical activation of VDR by using its agonist 1a,25-dihydroxyvitamin D3 efficiently enhanced the pro-differentiation capacity of UC-MSC and then alleviated malignant burden in AML mouse model.Based on these discoveries,to evade the risk of hypercalcemia,we synthetized and identified sw-22,a novel non-steroidal VDR agonist,which exerted a synergistic prodifferentiation function with UC-MSC on mitigating the progress of AML.Collectively,our findings provided a non-gene editing MSC-based therapeutic regimen to overcome the differentiation blockade in AML. | Luchen Sun Nanfei Yang Bing Chen Yuncheng Bei Zisheng Kang Can Zhang Nan Zhang Peipei Xu Wei Yang Jia Wei Jiangqiong Ke Weijian Sun Xiaokun Li Pingping Shen | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 2 | Experimental study and assessment of thermal energy storage mortar with paraffin/recycled brick powder composite phase change materials显示文摘Thermal energy storage recycled powder mortar(TESRM)was developed in this study by incorporating paraffin/recycled brick powder(paraffin/BP)composite phase change materials(PCM).Fourier transform infrared and thermogravimetric analysis results showed that paraffin/BP composite PCM had good chemical and thermal stability.The onset melting temperature and latent heat of the composite PCM were 46.49°C and 30.1 J·g−1.The fresh mortar properties and hardened properties were also investigated in this study.Paraffin/BP composite PCM with replacement ratio of 0%,10%,20%,and 30%by weight of cement were studied.The results showed that the static and dynamic yield stresses of TESRM were 699.4%and 172.9%higher than those of normal mortar,respectively.The addition of paraffin/BP composite PCM had a positive impact on the mechanical properties of mortar at later ages,and could also reduce the dry shrinkage of mortar.The dry shrinkage of TESRM had a maximum reduction about 26.15%at 120 d.The thermal properties of TESRM were better than those of normal mortar.The thermal conductivity of TESRM was 36.3%less than that of normal mortar and the heating test results showed that TESRM had good thermal energy storage performance. | Luchen HAO Jianzhuang XIAO Wanzhi CAO Jingting SUN | 2022 | Frontiers of Structural and Civil Engineering2022，16，10： | 0 |
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