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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | pH-Mediated fluorescence and G-quadru-plex binding of amido phthalocyanines 显示文摘 | Alzeer J Luedtke N W | 2010 | Biochemistry2010，49，： | 1 |
| 3 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B | 1979 | Geoehim Cosmoehim Acta1979，43，7： | 1 |
| 4 | Guanidinoglycosides : A novel family of RNA ligands显示文摘 | Luedtke NW Baker TJ Goodman M | 2002 | J Am Chem Soc2002，122，12： | 1 |
| 5 | Comparison of titanium elastic nails with traction and a spica cast to treat femoral fractures in children显示文摘 | Flynn J M Luedtke L M Ganley T J | 2004 | J Bone Joint Surg Am2004，86，4： | 1 |
| 6 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B Maynard V | 1979 | Geochim Cosmochim Acta1979，43，7： | 1 |
| 7 | Chronic toxicity of ammonia to rainbow trout显示文摘 | Thurston R V Russo R C Luedtke R J | 1984 | Trans Am Fish Soc1984，113，： | 1 |
| 8 | Incurred sample reproducibility:views and recommendations by the European Bioanalysis Forum显示文摘 | TIMMERMAN P LUEDTKE S Van AMSTERDAM P | 2009 | Bioanalysis2009，1，6： | 1 |
| 9 | Evaluation of off-label prescribing at a children' s rehabilitation center 显示文摘 | LUEDTKE K E BUCK M L | 2014 | J Pediatr Pharmaeol Ther2014，19，4： | 1 |
| 10 | 显示文摘 | Landman U | 1989 | Phys Rev B1989，40，： | 1 |
| 11 | A review of avascular nec- rosis in developmental dysplasia of the hip and contemporary efforts at prevention 显示文摘 | Luedtke LM Flynn JM Pill SG | 2000 | The University of Pennsylvania Or- thopaedic Journal2000，13，： | 1 |
| 12 | Duloxetine in the treatment of chronic pain due to fibromyalgia and diabetic neuropathy 显示文摘 | Wright A Luedtke KE Vandenberg C | 2010 | J Pain Res2010，4，： | 1 |
| 13 | Metabolic labeling of DNA by purine analogues in vivo显示文摘 | Anne B Neef Florent Samain Nathan W Luedtke | 2012 | Chem Bio Chem2012，13，12： | 1 |
| 14 | AtomisticMechanisms and Dynamics of Adhesion, Nanoindent- ation, and Fracture 显示文摘 | Landman U Luedtke W D Burnham N | 1990 | Science1990，248，4954： | 1 |
| 15 | Atomistic mechanisms of adhesive contact formation and interracial processes显示文摘 | Landman U Luedtke W D Ringer E M | 1992 | Wear1992，153，1： | 1 |
| 16 | Atomistic mechanisms and dynamics of adhesion, nanoindentation and fracture 显示文摘 | Landman U Luedtke W | 1990 | Science1990，248，： | 1 |
| 17 | Comparison of titanium elastic nails with traction and a spica cast to treat femoral fractures in children显示文摘 | Flynn JM Luedtke LM Gangley TJ | 2004 | J Bone Joint Surg Am2004，86，： | 1 |
| 18 | A sampling approximation approach for optimization with probabilistic constraints显示文摘 | Luedtke J Ahred S | | 0，，2： | 1 |
| 19 | The marine phosphorus cycling 显示文摘 | Froelich P N Bender M L Luedtke N A | 1982 | Am J Sci1982，282，： | 1 |
| 20 | Atomistic mechanisms and dynamics of adhesion,nanoindentation and fracture显示文摘 | Landman U Luedtke W D Nancy A B | 1990 | Science1990，248，4： | 1 |
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