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1篇 您的检索式:作者名="Luguang Ding"
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1Cellular modulation by the mechanical cues from biomaterials for tissue engineering显示文摘Mechanical cues from the extracellular matrix(ECM)microenvironment are known to be significant in modulating the fate of stem cells to guide developmental processes and maintain bodily homeostasis.Tissue engineering has provided a promising approach to the repair or regeneration of damaged tissues.Scaffolds are fundamental in cell-based regenerative therapies.Developing artificial ECM that mimics the mechanical properties of native ECM would greatly help to guide cell functions and thus promote tissue regeneration.In this review,we introduce various mechanical cues provided by the ECM including elasticity,viscoelasticity,topography,and external stimuli,and their effects on cell behaviours.Meanwhile,we discuss the underlying principles and strategies to develop natural or synthetic biomaterials with different mechanical properties for cellular modulation,and explore the mechanism by which the mechanical cues from biomaterials regulate cell function toward tissue regeneration.We also discuss the challenges in multimodal mechanical modulation of cell behaviours and the interplay between mechanical cues and other microenvironmental factors.Qiang Wei Shenghao Wang Feng Han Huan Wang Weidong Zhang Qifan Yu Changjiang Liu Luguang Ding Jiayuan Wang Lili Yu Caihong Zhu Bin Li 2021Biomaterials Translational2021,2,4:0
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