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| 1 | Heme oxygenase system in hepatic ischemia-reperfusion injury显示文摘Hepatic ischemia-reperfusion injury (IRI) limits access to transplantation. Heme oxygenase-1 (HO-1) is a powerful antioxidant enzyme which degrades free heme into biliverdin,free iron and carbon monoxide. HO-1 and its metabolites have the ability to modulate a wide variety of inflammatory disorders including hepatic IRI. Mechanisms of this protective effect include reduction of oxygen free radicals,alteration of macrophage and T cell phenotype. Further work is required to understand the physiological importance of the many actions of HO-1 identified experimentally,and to harness the protective effect of HO-1 for therapeutic potential. | James A Richards Stephen J Wigmore Luke R Devey | 2010 | World Journal of Gastroenterology2010，16，48： | 14 |
| 2 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 3 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 4 | Entry of hepatitis B and C viruses — recent progress and future impact显示文摘 | Thomas F Baumert Luke Meredith Yi Ni Daniel J Felmlee Jane A McKeating Stephan Urban | 2013 | Current Opinion in Virology2013，，： | 3 |
| 5 | Effects of antiagglomerants on the interactions between hydrate particles显示文摘 | Mark R A J Dalton Y Luke H | 2007 | American Institute of Chemical Engineers2007，54，2： | 1 |
| 6 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 7 | Theoretical study of the carbenoid CH2FLi 显示文摘 | Luke B T Pople J A | 1983 | Chem Phys Lett1983，102，： | 1 |
| 8 | Reconstruction of skull base and fronto-orbital defects following tumor resection显示文摘 | LAEDRACH K LUKES A RAVEH J | 2007 | Skull Base2007，17，1： | 1 |
| 9 | Towards a critical, worldly, literacy 显示文摘 | LUKE A ELKINS J | 2002 | Journal of Adolescent & Adult Literacy2002，45，15： | 1 |
| 10 | Stromelysin-1 and gelatinase A are upregulated before TNF-a in LPS-stimulated neuroin ammation显示文摘 | Mun-Bryce S Lukes A Wallace J | 2002 | Brain Res2002，33，9： | 1 |
| 11 | The family of five : TIR - domain - containing adaptors in Toll - like receptor signaling 显示文摘 | Luke A J O Andrew G B | 2007 | Nat Rev Immunol2007，7，： | 1 |
| 12 | Nuclear magnetic resonance imaging in multiple sclerosis 显示文摘 | Lukes S A Crookes L E Aminoff M J | 1983 | Ann Neurol1983，13，： | 1 |
| 13 | Acute subdural hematoma from ruptured cerebral aneurysm 显示文摘 | Marbacher S Fandino J Lukes A | 2010 | Acta Neurochir (Wien)2010，152，3： | 1 |
| 14 | Reconstruction of skull baseand fronto-orbital defect following tumor resection显示文摘 | Laedrach K Lukes A Raveh J | 2007 | SkullBase2007，17，1： | 1 |
| 15 | Dithiadiazolium salts as initiators for the cationic ring-opening polymerization of tetrahydrofuran显示文摘 | Banister A J Luke A W | 1992 | J Polym Sci Part A1992，30，： | 1 |
| 16 | After the Toll rush显示文摘 | Luke A J O’Neill | 2004 | Science2004，303，5663： | 1 |
| 17 | Human Salivary Glucose Analysis by High-performance ion -exchange Chromatography and Pulsed Amperometric Detection显示文摘 | Gough H Luke G A Beeley J A | 1996 | Archives of Oral Biology1996，41，2： | 1 |
| 18 | Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimnlated neuroninflammation 显示文摘 | Mun-Bryce S Lukes A Wallace J | 2002 | Brain Res2002，933，1： | 1 |
| 19 | Making community texts objects of study显示文摘 | Luke A&O’Brien J&Comber B | 1994 | The Australian Journal of Language and Literacy1994，，17： | 1 |
| 20 | Hark back: passive immunotherapy for influenza and other serious infections 显示文摘 | Luke TC Casadevall A Watowich S J | 2010 | Crit Care Med2010，38，： | 1 |
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