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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 3 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | LUKE T W T PATEL J JENNINGS N R | 2006 | Journal of Autonomous Agent Multi-Agent System2006，13，12： | 1 |
| 4 | Sputtering of Lithium Compounds for Preparation of Electrolyte Thin Films显示文摘 | Dudney N J Bates J B Luke C F | 1992 | Solid State Ionics1992，5356，： | 1 |
| 5 | Microscopic enteritis:Bucharest consensus显示文摘Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient deficiency.It is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern endoscopy.This work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical relevance.The consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and treatment.Following the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,independently.There was strong agreement on all statements about ME histology(95%-100%).Statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of ME.There was strong agreement on the histological definition of ME.Weaker agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for management.This ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy. | Kamran Rostami David Aldulaimi Geoffrey Holmes Matt W Johnson Marie Robert Amitabh Srivastava Jean-Francois Fléjou David S Sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan Sauid Ishaq Mohammad Rostami-Nejad A Salvador Pe?a Gabrio Bassotti Michael N Marsh Vincenzo Villanacci | 2015 | World Journal of Gastroenterology2015，21，9： | 1 |
| 6 | Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes 显示文摘 | Gardiner N J Wang Z C Luke C | 2007 | Brain Res2007，1175，： | 1 |
| 7 | A provincial program of blood conservation:The Ontario Transfusion Coordinators(ONTra C)显示文摘 | Freedman J Luke K Monga N | 2005 | Transfus Apher Sci2005，33，3： | 1 |
| 8 | Electron trapping nonuniformity in high-pressure-Bridg- man-grown CdZnTe显示文摘 | AMMAN M LEE J S LUKE P N | 2002 | J Appl Phys2002，92，6： | 1 |
| 9 | Lower Critical Solution Temperature Control and Swelling Behaviour of Physically Crosslinked Thermosensitive Copolymers Based on N-isopropylacrylamide 显示文摘 | LUKE M G DECLAN M D MICHAEL J D N | 2006 | European Pulymer Journal2006，42，： | 1 |
| 10 | Suicide ideation and attempt in a community cohort of urban Aboriginal youth:A cross-sectional study显示文摘 | Luke J N Anderson I P Gee G J | 2013 | Crisis2013，34，4： | 1 |
| 11 | TRA- VOS: Trust and reputation in the context of inaccurate information sources 显示文摘 | LUKE T W T PATEL J JENNINGS N R | 2006 | Journal of Autonomous Agent Multi-Agent System2006，，12： | 1 |
| 12 | TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources显示文摘 | LUKE T W T PATEL J JENNINGS N R | 2006 | Journal of Autonomous Agent Multi-agent System2006，，12： | 1 |
| 13 | Revealing the role of phos- pholipase CI33 in the regulation of VEGF-induced vascular permeability 显示文摘 | Luke H Kathryn N Karl J | 2012 | Blood2012，120，11： | 1 |
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