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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 3 | Industrial applications of electrical tomography to solid conveying显示文摘 | LUKE S P WILLIAMS R A | 1997 | Measurement & Control1997，，30： | 1 |
| 4 | Biasing coevolutionary search for optimal multiagent behaviors显示文摘 | PANAIT L LUKE S WIEGAND R P | 2007 | IEEE Transactions on Evolutionary Computation2007，10，6： | 1 |
| 5 | 'One-pot' meth- ylation of Fmoc amino acids 显示文摘 | R W A Luke P G T Boyce E K Dorling | 1996 | Tetrahedron Lett1996，37，2： | 1 |
| 6 | Electroph-ysiological abnormalities in age-related macular degeneration显示文摘 | Walter P Widder RA Luke C Konigsfeld P Brunner R | 1999 | Graefe Arch Clin Exp Ophthalmol1999，237，12： | 1 |
| 7 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 8 | Strategic hospital alli-ances:do the type and market structure of strategic hospital alli-ances matter?显示文摘 | MCCUE M J CLEMENT J P LUKE R D | 1999 | Medical care1999，37，10： | 1 |
| 9 | Genetic associations of inflammatory bowel disease in a South Asian population显示文摘AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 R :rs11805303, ARPC2 :rs12612347, IRGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGR2 A :rs3737240, PTGER4 :rs4613763, IL17 REL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMURF1 :rs7809799, LAMB1 :rs886774, HLA-DRB5, DQA1, DRB1, DRA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values < 0.003 were considered significant.RESULTS A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(OR = 1.66, P < 0.001) and remained in remission(OR = 1.48, P < 0.001). A positive association was noted between rs10045431(IL 12 B gene) and upper gastrointestinal involvement in CD(OR = 4.76, P = 0.002). CONCLUSION This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians. | Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin De Silva Nimna Rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi Silva Metthananda Nawarathne Ranjith K Peiris Udaya P Kalubovila Sujeewa R Kumarasena Vajira Harshadeva Weerabaddana Dissanayake Rohan W Jayasekara Hithanadura Janaka de Silva | 2018 | World Journal of Clinical Cases2018，6，15： | 1 |
| 10 | Hydrogen peroxide and ozone formation in hybrid gas-liquid electrical discharge reactors显示文摘 | LUKES P APPLETON A T LOCKE B R | 2004 | IEEE Transactions on Industry Applications2004，40，1： | 1 |
| 11 | Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung 显示文摘 | Luke W P Pearson F G Todd R J | 1986 | J Thorac Cardiovasc Surg1986，91，： | 1 |
| 12 | Hydrogen peroxide and ozone formation in hybrid gas-liquid electrical discharge reactors 显示文摘 | Lukes P Appleton A Locke B R | 2004 | IEEE Trans Ind Appl2004，40，1： | 1 |
| 13 | 'One -pot' methylation of Fmoc amino acids显示文摘 | Luke R W A Boyce P G T Dorling E K | 1996 | Tetrahedron Letters1996，37，2： | 1 |
| 14 | Application of conjugate harmonics to electrical process tomography 显示文摘 | Ostrowski K L Luke S P Williams R A | 1996 | Meas Sci Technol1996，7，： | 1 |
| 15 | Prospective evaluation of mediastinoscopy for assessment of the lung显示文摘 | Luke W P Pearson F G Todd T R | 1986 | Thorac Cardiovase Surg1986，91，1： | 1 |
| 16 | Simulation of the performance of electrical capacitance tomography for measurement of dense phase pneumatic conveying 显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，6，： | 1 |
| 17 | Real time visualization and analysis of dense phase powder conveying 显示文摘 | Ostrowski K L Luke S P Bennet M A Wilhams R A | 1999 | Powder Technology1999，102，1： | 1 |
| 18 | Simulation of the performance of electrical capacitance topography for measurement of dense phase pneumatic conveying显示文摘 | OSTROWSKI K L LUKE S P WILLIAMS R A | 1997 | Chemical Engineering Journal1997，68，23： | 1 |
| 19 | Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung显示文摘 | Luke W P Pearson F G Todd T R | 1986 | J Thorac Cardiovasc Sung1986，91，1： | 1 |
| 20 | Plasma chemical oxidation processes in ahybrid gas-liquid electrical discharge reactor 显示文摘 | Lukes P Locke B R | 2005 | Journal ofPhysics D: Applied Physics2005，38，： | 1 |
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