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| 1 | Measurement of gaseous and aqueous trace formaldehyde:Revisiting the pentanedione reaction and field applications显示文摘 | Li J Dasgupta P K Luke W | 2005 | Anal Chim Acta2005，531，： | 1 |
| 2 | 'One-pot' meth- ylation of Fmoc amino acids 显示文摘 | R W A Luke P G T Boyce E K Dorling | 1996 | Tetrahedron Lett1996，37，2： | 1 |
| 3 | Genetic associations of inflammatory bowel disease in a South Asian population显示文摘AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 R :rs11805303, ARPC2 :rs12612347, IRGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGR2 A :rs3737240, PTGER4 :rs4613763, IL17 REL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMURF1 :rs7809799, LAMB1 :rs886774, HLA-DRB5, DQA1, DRB1, DRA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values < 0.003 were considered significant.RESULTS A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(OR = 1.66, P < 0.001) and remained in remission(OR = 1.48, P < 0.001). A positive association was noted between rs10045431(IL 12 B gene) and upper gastrointestinal involvement in CD(OR = 4.76, P = 0.002). CONCLUSION This confirms the heterogeneity of allelic mutations in South Asians compared to Caucasians. Most SNPs and disease associations reported here have not been described in South Asians. | Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin De Silva Nimna Rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi Silva Metthananda Nawarathne Ranjith K Peiris Udaya P Kalubovila Sujeewa R Kumarasena Vajira Harshadeva Weerabaddana Dissanayake Rohan W Jayasekara Hithanadura Janaka de Silva | 2018 | World Journal of Clinical Cases2018，6，15： | 1 |
| 4 | Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung 显示文摘 | Luke W P Pearson F G Todd R J | 1986 | J Thorac Cardiovasc Surg1986，91，： | 1 |
| 5 | Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi:CD45RBlo T-cell proportions显示文摘 | Luke P P W Deng J P Lian D | | 0，，09： | 1 |
| 6 | Modern air craft hangars: A review of the design trends显示文摘 | LUKE STEVEN J HOWSON W P | 2002 | Structural Engineer2002，80，15： | 1 |
| 7 | 'One -pot' methylation of Fmoc amino acids显示文摘 | Luke R W A Boyce P G T Dorling E K | 1996 | Tetrahedron Letters1996，37，2： | 1 |
| 8 | Prospective evaluation of mediastinoscopy for assessment of the lung显示文摘 | Luke W P Pearson F G Todd T R | 1986 | Thorac Cardiovase Surg1986，91，1： | 1 |
| 9 | Improved identification of volcanic features using Landsat 7 ETM+显示文摘 | Luke P F Andrew J L H Robert W | 2001 | Remote Sensing of Environment2001，78，12： | 1 |
| 10 | Prospective evaluation of mediastinoscopy for assessment of carcinoma of the lung显示文摘 | Luke W P Pearson F G Todd T R | 1986 | J Thorac Cardiovasc Sung1986，91，1： | 1 |
| 11 | Alteration in CD45RBhi/CD45RBlo T-cell ratio following CD45RB monoclonal-antibody therapy occurs by selective deletion of CD45RBhi effector cells显示文摘 | Luke P P W Deng J P O'Brien C A | | 0，，02： | 1 |
| 12 | Measurement of gaseous and aqueous trace formaldehyde: Revisiting the pentanedione reaction and field applications 显示文摘 | Li J Dasgupta P K Luke W | 2005 | AnalyticaChimicaActa2005，531，1： | 1 |
| 13 | Denosine kinase deficiency in associated with developmental abnormalities and reduced transmethylation显示文摘 | Barbara A M Yvonne Y S Mike S A Jamie D S,Luiz A P,Margarita I T,Peter S S,Elizabeth A W,Luke M M,Conrad W A | | 0，，： | 1 |
| 14 | A barley cultivation asso- ciated polymorphism conveys resistance to powdery mildew 显示文摘 | Pietro P L Luke R S Robbie W H | 2004 | Nature2004，430，： | 1 |
| 15 | A barley cultivatlon-associated polymorphism conveys resistance to powdery mildew 显示文摘 | Pierre P L Luke R S Robbie W H | 2004 | Nature2004，430，： | 1 |
| 16 | 'One-pot' methylation of Fmoc amino acids 显示文摘 | Luke R W A Boyce P G T Dorling E K | 1996 | Tetrahedron Lett1996，37，2： | 1 |
| 17 | The efficacy of gauze packing in liver tauma:an evaluation of the management and treatment of liver truma显示文摘 | Susanne H E Christian Van der W Luke P H | 2002 | Euro J Trauma2002，3，： | 1 |
| 18 | 热文点评原文摘要显示文摘中文:背景患者入院后可从不当消毒的环境表面获得多药耐药菌和艰难梭菌。本文确定了3种强化的终末消毒(入住同一病房的两名患者之间的消毒)策略,对感染耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)、艰难梭菌(CD)和多重耐药不动杆菌的影响。方法本文在美国东南部的9家医院开展了一项务实的、集群-随机、交叉研究。凡曾有感染或定植目标细菌感染患者居住过的病房,患者出院后随机采取4种消毒策略中的一种方法进行终末消毒:对照(季胺盐类消毒剂消毒,但凡遇到CD采用含氯消毒剂);UV(季胺盐类+UV-C消毒,但凡遇到CD采用含氯消毒剂+UV-C);含氯消毒剂;含氯消毒剂+UV-C。凡入住目标病房的患者被列为暴露人群。这4种终末消毒方法分别在每家医院连续实施7个月的周期。本文随机设计这几种消毒策略在每家医院内的实施顺序(1:1:1:1)。主要产出的结果是,观察暴露患者中目标细菌的感染的发生或定植情况,以及ITT人群中暴露患者CD感染发生率。本研究ClinicalTrials.gov注册编号:NCT01579370。结果共有31226名患者暴露,其中21395(69%)符合标准,包括4916名对照组,5178名UV组,5438名含氯消毒剂组,以及5863名含氯消毒剂+UV组。在对照组中,22426个暴露日中有115名患者发生目标细菌的感染(51.3/10000暴露日)。在标准清洁策略的基础上增加UV消毒的暴露患者,其目标细菌感染的发生率明显较低(n=76;33.9/10000暴露日;RR:0.70,95%CI:0.50~0.988;P=0.036)。含氯消毒剂组(n=101;41.6/10000暴露日;RR:0.85,95%CI:0.69~1.04;P=0.116),或含氯消毒剂+UV组患者(n=131;45.6/10000暴露日;RR:0.91,95%CI:0.76~1.09;P=0.303)的目标细菌的感染率,其差异无统计学意义。同样,在含氯消毒剂的基础上增加UV消毒,暴露患者中CD感染率也没有发生改变((n=38vs36;30.4vs31.6/10000暴露日;RR:1.0,95%CI:0.57-1.75;P=0.997)。解释污染的医疗机构环境是获得病原微生物的重要来源;强化终末消毒可以降低这一风险。 | Deverick J Anderson Luke F Chen David J Weber Rebekah W Moehring Sarah S Lewis Patricia F Triplett Michael Blocker Paul Becherer J Conrad Schwab Lauren P Knelson Yuliya Lokhnygina William A Rutalo Hajimori Kanamori Marina F Gergen Daniel J Sexton | 2018 | 中华医院感染学杂志2018，28，12： | 1 |
| 19 | Fluoroquinolone treatment of experimental Salmonella enterica serovar Typhimurium DT104 infections in chickens selects for both gyrA mutations and changes in efflux pump gene expression显示文摘 | Luke P R Deborah J E Sue W C | 2005 | Antimicrobial Agents and Chemotherapy2005，56，2： | 1 |
| 20 | Improved identification of volcanic features using Landsat 7 ETM+ 显示文摘 | Luke P F Andrew J L H Robert W | 2001 | Remote Sensing of Environment2001，78，12： | 1 |
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