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您的检索式：作者名="Luling Xiong"
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| 1 | Two awn-development-related peptides,GAD1 and OsEPFL2,promote seed dispersal and germination in rice显示文摘In nature,seed dispersal and germination are crucial for plant survival and propagation.Elaborate mechanisms have evolved that enhance the success of these events(Peart,1981;Bewley,1997),and the widespread distribution of grass species has been associated with the evolution of these traits.Many of these mechanisms are associated with characteristics that are intrinsic to the seed,such as awn development,seed shattering,and germination(Ntakirutimana et al.,2019).Awns and/or other seed appendages often help mature seeds to disperse widely and germinate under various challenging environments(Elbaum et al.,2007). | Jing Jin Luling Xiong Julie E.Gray Bin Hu Chengcai Chu | 2023 | Molecular Plant2023，16，3： | 1 |
| 2 | Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma显示文摘Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of cancer.However,conventional cell-SELEX technologies for aptamer discovery are time-consuming and laborious.Here we discovered a new aptamer BC-3 by using an improved rapid X-Aptamer selection process for human bladder carcinoma,for which there is no specific molecular probe yet.We show that BC-3 exhibited excellent affinity in bladder cancer cells but not normal cells.We demonstrate that BC-3 displayed high selectivity for tumor cells over their normal counterparts in vitro,in mice,and in patient tumor tissue specimens.Further endocytosis pathway analysis revealed that BC-3 internalized into bladder cancer cells via clathrin-mediated endocytosis.Importantly,we identified ribosomal protein S7(RPS7)as the binding target of BC-3 via an integrated methodology(mass spectrometry,colocalization assay,and immunoblotting).Together,we report that a novel aptamer BC-3 is discovered for bladder cancer and its properties in the disease are unearthed.Our findings will facilitate the discovery of novel diagnostic and therapeutic strategies for bladder cancer. | Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu Yi Xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu | 2023 | Genes & Diseases2023，10，5： | 0 |
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