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| 1 | Response of testicular antioxidant enzymes to hexachlorocy clohexane is species specific显示文摘Aim:To find out whether the response of testicular oxidative stess parameters to hexachlorocyclohexane(HCH)is species specific.Methods:In rats and mice(n=5in each group).HCHwas administered at a dose of 20mg/kg/day intraperitoneally for 30daysin0.1ml of refined rgoundnut oil.The control groups received equal volume of the vehicle.Animals were sacrificed 24hours after the last injection and various oxidative stress parameters were measured immediately.Results:The level of both endogenous as well as FeSO4and ascorbic acid-stimulated lipid peroxidation was increased significantly in the HCH-treated rats,whereas the pattern was just the reverse in case of mice.Although the level of H2O2content increased inresponse to HCHinboth groups,a totally different trend was observed for the activity of the principal H2O2-metabolising emzyme,catalase,In case of rats,a significant decline inthe activity of catalase was recorded in response to HCH whereas a sharp augmentation in the enzyme activity was noticed im mice,Similarly,the decreased activity of superoxide dismutase observed in rast remained unaltered in mice.Conclusion:HCH induces oxidative stress in the testis of both rats and mice,However,the pattern of response of testicular oxidative stress parameters seems to be species specific. | Luna Samanta G.B.N. Chainy | 2002 | Asian Journal of Andrology2002，4，3： | 6 |
| 2 | Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility显示文摘由他们表示的水平的比较 proteomics 和确认与精索静脉曲张在不肥沃的人在精子蛋白质的分发学习主要差别。为每精索静脉曲张结果的学习特定的估计被联合识别不管他们的临床的精索静脉曲张的舞台和对一个侧面的偏重,在人涉及联系精索静脉曲张的不孕的蛋白质。5 关键蛋白质(PKAR1A, AK7, CCT6B, HSPA2,和 ODF2 ) 的表达式层次在压力反应包含了,包括分子的女伴的精子功能被西方的弄污验证。99 蛋白质是在精索静脉曲张组表示的差别。涉及主要精力新陈代谢和关键精子功能的超过 87% DEP 是在精索静脉曲张组的 underexpressed。在精索静脉曲张组影响的关键蛋白质功能是精子发生,精子活动性,和 mitochondrial 机能障碍,它被西方的弄污进一步验证,支持 proteomics 分析。精索静脉曲张是实质上由于损害的血供应的精力剥夺,组织缺氧,和过高热的一个状态,它被类脂化合物新陈代谢, mitochondrial 电子运输链,和克雷布斯周期的下面规定支持酶。支持 proteomic 分析,兴趣的 5 识别蛋白质的表示被西方的弄污验证。这研究向建立 biomarker “ 作出贡献; fingerprint”根据分子的参数估计精子质量。 | Ashok Agarwal Rakesh Sharma Luna Samanta Damayanthi Durairajanayagam Edmund Sabanegh | 2016 | Asian Journal of Andrology2016，18，2： | 6 |
| 3 | Oxidative Stress and Heart Failure in Altered Thyroid States显示文摘 | Pallavi Mishra Luna Samanta B. Biondi L. Lanfrancone E. Skalidis F. Thuny | 2012 | The Scientific World Journal2012，，： | 1 |
| 4 | Age-related changes in rat testicular oxidative stress parameters by hexachlorocyclohexane显示文摘 | Luna Samanta Arjun Sahoo G. B. N. Chainy | 1999 | Archives of Toxicology1999，，2： | 1 |
| 5 | Proteomic analysis reveals dysregulated cell sign aling in ejaculated spermatozoa from in fertile men显示文摘Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile men.Spermatozoa from infertile men were fractioned on three-layer density gradient(80%,60%,and 40%).Fraction 1(Fl)refers to the least mature stage having the lowest den sity,whereas the fraction 4(F4)in eludes the most dense and morphologically mature motile spermatozoa.Fraction 2(F2)and fraction 3(F3)represent the intermediate stages.Proteins were extracted and separated by dimensional gel.Bands were digested with trypsin and analyzed on a LTQ-Orbitrap Elite hybrid mass spectrometer system.Functional annotations of proteins were obtained using bioinformatics tools and pathway databases.A total of 1585 proteins were detected in the four fractions of spermatozoa.A dysregulated protein turnover and protein folding may lead to accumulation of defective proteins or proteins that otherwise would have been eliminated during the process of maturation,resulting in the impairment of sperm fun ction.Aberra nt chaper one expressi on may be a major con tributing factor to the defective sperm function.Androge n receptor was predicted as a transcription regulator in one of the networks and the affected pathways were chaperone-mediated stress response,proteosomal pathway,and sperm function.The down regulation of key pathways and protei ns which compromises the fertilizi ng potential of spermatozoa may provide in sight into the mecha nisms that lead to male infertility. | Luna Samanta Rakesh Sharma Zhihong Cui Ashok Agarwal | 2019 | Asian Journal of Andrology2019，21，2： | 0 |
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