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| 1 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Pharmacokinetics of nicotine in healthy elderly people 显示文摘 | Molander L Hansson A Lunell E | 2001 | Clin Pharmacol Ther2001，69，1： | 1 |
| 3 | Site of nicotine absorption from a vapour inhaler-comparison with cigarette smoking 显示文摘 | Lunell E Molander L Ekberg K | 2000 | Eur J Clin Pharmacol2000，55，： | 1 |
| 4 | Vibrational control of nonlinear time lag systems with bounded delay:Averaging theory,stabilizability,and transient behavior显示文摘 | Lehman B Bentsman J Lunel S V Verriest E I | 1994 | IEEE Transactions on Automatic Control1994，39，： | 1 |
| 5 | Marfan、syndrome and pregnancy显示文摘 | Lunel A Audra P Plauchu H | 2006 | Gynecol Obstet Biol Reprod2006，35，6： | 1 |
| 6 | Sexuality after sigmoid vaginoplasty in patients with Mayer-Rokitansky-Ktister- Hauser syndrome显示文摘 | Carrard C Chevret-Measson M Lunel A | 2012 | Fertil Steril2012，97，3： | 1 |
| 7 | Vibrational control of nonlinear time lag systems with bounded delay: Averaging theory, stability, and transient behavior显示文摘 | Lehnan B bentsman J Lunel S V Verriest E I | 1994 | IEEE Trans Automat Contr1994，39，： | 1 |
| 8 | Quality of life in der-matology显示文摘 | Halioua B Beumont MG Lunel F | 2000 | Int J Dermatol2000，39，11： | 1 |
| 9 | The closure of the gesneralised eigenspace of a class of infinitesimal generators显示文摘 | | 1991 | Proceedings of the Royal Society of Edinburgh1991，117，： | 1 |
| 10 | Hepatitis C virus genotypes and subtypes in patients with hepatitis C, with and without cryoglobulinemia显示文摘 | Lionel Frangeul Lucile Musset Pascale Cresta Patrice Cacoub Jean-Marie Huraux Fran?oise Lunel | 1996 | Journal of Hepatology1996，，4： | 1 |
| 11 | Nosocomial fungal infections:candidemia显示文摘 | Verduyn Lunel F M Meis J F Voss A | 1999 | Diagn Microbiol Infect Dis1999，34，3： | 1 |
| 12 | Trends in fungaemia and antifungal susceptibility in the Netherlands显示文摘 | Verduyn Lunel F Koeleman JG Spanjaard L | 2006 | Neth J Med2006，64，7： | 1 |
| 13 | Oral lichen planus and hepatitis C virus infection:a fortuitous association?显示文摘 | Dupin N Chosidow O Lunel F | 1997 | Arch Dermatol1997，133，8： | 1 |
| 14 | Nosocomial fungal infections: Candidemia显示文摘 | Meis JFGM VOSS A | 1999 | Diagn Microbiol Infect Dis1999，34，3： | 1 |
| 15 | Marfan's syndrome and pregnancy显示文摘 | Lunel A Audra P Plauchu H | 2006 | Gynecol Obstet Biol Reprod2006，35，6： | 1 |
| 16 | Index in intrauterine growth retardation of fetal or maternal origin显示文摘 | Nylund L Lunell NO Lewander R | 1983 | Br J Obstet Gynaecol1983，90，： | 1 |
| 17 | Poly-lactic acid synthesis for application in biomedical devices显示文摘 | Laspril a AJ Martinez GA Lunel i BH | | 0，，01： | 1 |
| 18 | Nosocomial fungal infections: candidemia显示文摘 | Verduyn Lunel FM Meis JF Voss A | 1999 | Diagn Microbiol Infect Dis1999，34，： | 1 |
| 19 | Non-organ specific auto-antiodies with chrnic C virus hepatitis显示文摘 | Abuaf N Lunel F Giral P | 1993 | Journal of Hepatology1993，18，： | 1 |
| 20 | Hepatitis C virus infection and cryoglobulinemia显示文摘 | Lunel F Musset L | 1998 | J Hepatol1998，29，5： | 1 |
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