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| 1 | Impact of virus genotype on interferon treatment of patients with chronic hepatitis C: a multicenter controlled study显示文摘BACKGROUND: Some factors have been reported to besassociated with a greater likelihood of sustained viral re-sponse ( SVR) in the interferon (IFN) treatment of chronichepatitis C. The factors include HCV genotype, HCVRNA level in serum, state of liver disease, baseline bodyweight, age, sex, and race. The aim of this trial was to in-vestigate the influence of HCV genotype on the IFN treat-ment of patients with chronic hepatitis C.METHODS: The genotypes of HCV virus were determinedin the patients with chronic hepatitis C from several hospi-tals of China enrolled into the randomized, opened andcontrolled trial of Peg-IFN alpha-2a (pegasys) treatment,controlled with IFN-α-2a (roferon-A). The serum ALTlevels and HCV RNA concentrations of the patients weredetected before and at the end of treatment and during thefollow-up. The influence of HCV genotype on the IFNtreatment of patients with chronic hepatitis C was analyzedin intention-to-treat (ITT) population.RESULTS: The HCV genotypes of 202 patients were deter-mined. Of these patients, 158(78.22%) were infected withgenotype 1 HCV and 44(21.78%) with genotype non-1.The viral response at the end of treatment (ETVR) andsustained viral response (SVR) rates were 53.80% and25.32% respectively in patients with genotype 1 HCV, butthey were 61.36% and 43.18% in patients with genotypenon-1. The difference of SVR between patients with geno-type 1 HCV and those with genotype non-1 was significant(P =0.021). After being grouped by the used drugs, theETVR rates of patients infected with genotype 1 and non-1HCV were 76.83% and 80.95% in the patients treated withpegasys (P =0.686); but their SVR rates were 35.37% and66.67% (P =0. 01). The viral relapse rate of genotype 1HCV (55.56%) was significantly higher than that of geno-type non-1 HCV (23.53%) (P=0.02). In roferon-A group,the ETVR and SVR rates of patients with genotype 1 HCVwere 28.95% and 14.47% respectively, which were lowerbut not more significant than those of patients with geno-type non-1 HCV (43.48% and 21.74%). Moreover, the vi-ral relapse rate of genotype 1 HCV (72.73%) was higherbut not more significant than that of genotype non-1 HCV(50.00%) (P=0.21).CONCLUSION: HCV genotype could affect the efficacies,mainly sustained responses, of IFN treatment in patientswith chronic hepatitis C, and the effects of IFN are relatedto drugs and therapeutic course. | Yao Xie, Dao-Zhen Xu, Zhi-Meng Lu, Kang-Xian Luo, Ji-Dong Jia, Yu-Ming Wang,Gui-Zhen Zhao, Shu-Lin Zhang and Da-Zhi Zhang Department of Infeetious Diseases , Beijing Ditan Hos-pital, Beijing 100011 , China Department of Infec-tious Diseases, Ruijin Hospital, Shanghai 200025, China De-partment of Infectious Diseases, Naifang Hospital, First Military Medical U-niversity, Guangzhou 510515, China (Luo KX) Center of Liver Disease,Beijing Friendship Hospital, Beijing 100050, China (Jia J D ) Institute ofInfectious Disease, Southwest Hospital, Third Military Medical University,Chongqing 410032, China Department of Infectious Disea-ses, Second Hospital, China Medical University, Shenyang 110004, China Department of Infectious Diseases, First Hospital, Xi’ an Jiao-tong University, Xi’ an 710061 , China ) Liver Disease Centerof Chongqing, Second Hospital, Chongqing Medical University,Chongqing 410010, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 2 |
| 2 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 3 | Effect of composition on the microstructure and mechanical properties of Mg-Zn-Al alloys 显示文摘 | ZHANG J GUO Z X PAN F S LI Z S LUO X D | 2007 | Mater Sci Eng A2007，456，12： | 1 |
| 4 | Direct interactions between HIF-1 alphaand Mdm2 modulate p53 function显示文摘 | Chen D Li M Luo J | 2003 | J Biol Chem2003，278，13： | 1 |
| 5 | An Inverse Aeroacoustic Problem on Rotor Wake/Stator Interaction 显示文摘 | Luo J Li X D | 2002 | Journal of Sound and Vibra- tion2002，254，2： | 1 |
| 6 | Population distribution and spatial structure in transitional chinese cities: A study o{ Nanjing, Eurasian 显示文摘 | LUO J WEI Y H D | 2006 | Geography and Ecomomics2006，，5： | 1 |
| 7 | Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole显示文摘 | Luo J D Xie Z L Lam J W Y | 2001 | Chem Commun2001，，： | 1 |
| 8 | Genetic control of rice plant architecture under domestication 显示文摘 | Jin J Huang W Gao J Yang J Shi M Zhu M Luo D Lin H | 2008 | Nature Genetics2008，40，11： | 1 |
| 9 | Investigation of gene effects and epistatic interactions between Aktl and neuregulin 1 in the regula- tion of behavioral phenotypes and social functions in genetic mouse models of schizophrenia显示文摘 | Huang C Pei J Luo D | 2014 | Front Behav Neurosci2014，8，： | 1 |
| 10 | Silver phosphate crystal growth by screw dislocation driven of dynamic-template 显示文摘 | Wang J D Liu J K Luo C X Lu Y Yang X H | 2013 | Crystal Growth & Design2013，13，11： | 1 |
| 11 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 12 | Changes and signifi- cance of HSP70 in Iiver with secondary hepatic injury in the earIy stage in rats after severe trauma 显示文摘 | LUO D L ZHOU J H LIU B H | 2002 | Chin J Emerg Med2002，11，2： | 1 |
| 13 | 显示文摘 | Luo C P Luo S H Sellmyer D J | 2000 | Journal of Applied Physics2000，87，9： | 1 |
| 14 | Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae 显示文摘 | Flores R Luo J Chen D | 2007 | Microbiology2007，153，3： | 1 |
| 15 | The dislocation microstructure of a nickel-base single crystal superalloy after tensile fracture 显示文摘 | LUO Z P WU Z T MILLER D J | 2003 | Materials Science and Engineering2003，，354： | 1 |
| 16 | Leaf traits and associated ecosystem characteristics across subtropical and timberline forests in the Gongga Mountains,Eastern Tibetan Plateau显示文摘 | LUO TX LUO J PAN Y D | 2005 | Oecologia2005，142，： | 1 |
| 17 | Material removal regions in chemical mechanical planarization for submicron integrated circuit fabrication:Coupling effects of slurry chemicals,abrasive size distribution,and wafer-pad contact area显示文摘 | Luo J F Doronfeld D A | 2003 | IEEE Transactions on Semiconductor Manufacturing2003，16，1： | 1 |
| 18 | Face recognition using spatially con- strained earth mover's distance显示文摘 | Xu D Yan S C Luo J B | 2009 | IEEE Trans on image proces- sing2009，18，11： | 1 |
| 19 | Antioxidant activities of different fractions of polysaccharide purified from Gynostemma pentaphyllum Makino显示文摘 | WANG Z J LUO D H | 2007 | Carbohydrate Polymers2007，68，1： | 1 |
| 20 | Viral Myocarditis:Identification of five differentially expressed genes incoxsackievirus B3-infected mouse heart显示文摘 | Yang D Yu J Luo Z | 1999 | Circ Res1999，84，6： | 1 |
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