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| 1 | emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer显示文摘Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic or epigenetic alterations affecting almost 90%of Wnt/β-catenin gene members.A major challenge is thus learning how the corrupted coordination of this pathway is tied to other signalings to enhance cell growth.Peroxisome proliferator activated receptorγ(PPARγ)is emerging as a growth-limiting and differentiation-promoting factor.In tumorigenesis it exerts a tumor suppressor role and is potentially linked with the Wnt/β-catenin pathway.Based on these results,the identification of new selective PPARγmodulators with inhibitory effects on the Wnt/β-catenin pathway is becoming an interesting perspective.Should,in fact,these molecules display such properties,new research avenues would be opened aimed at developing new molecular targeted drugs.Herein,we review the basic principles and present new hypotheses underlying the crosstalk between Wnt/β-catenin and PPARγsignaling.Furthermore,we discuss the advances in our understanding as to how their altered regulation can culminate in colon cancer and the efforts aimed at designing novel PPARγagonists endowed with Wnt/β-catenin inhibitory effects to be used as therapeutic and/or preventive agents. | Lina Sabatino Massimo Pancione Carolina Votino Tommaso Colangelo Angelo Lupo Ettore Novellino Antonio Lavecchia Vittorio Colantuoni | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 2 | Potential therapeutic applications of mesenchymal stem cells for the treatment of eye diseases显示文摘Stem cell-based treatments have been extensively explored in the last few decades to develop therapeutic strategies aimed at providing effective alternatives for those human pathologies in which surgical or pharmacological therapies produce limited effects.Among stem cells of different sources,mesenchymal stem cells(MSCs)offer several advantages,such as the absence of ethical concerns,easy harvesting,low immunogenicity and reduced tumorigenesis risks.Other than a multipotent differentiation ability,MSCs can release extracellular vesicles conveying proteins,mRNA and microRNA.Thanks to these properties,new therapeutic approaches have been designed for the treatment of various pathologies,including ocular diseases.In this review,the use of different MSCs and different administration strategies are described for the treatment of diabetic retinopathy,glaucoma,and retinitis pigmentosa.In a large number of investigations,positive results have been obtained by in vitro experiments and by MSC administration in animal models.Most authors agree that beneficial effects are likely related to MSC paracrine activity.Based on these considerations,many clinical trials have already been carried out.Overall,although some adverse effects have been described,promising outcomes are reported.It can be assumed that in the near future,safer and more effective protocols will be developed for more numerous clinical applications to improve the quality of life of patients affected by eye diseases. | Giuliana Mannino Cristina Russo Anna Longo Carmelina Daniela Anfuso Gabriella Lupo Debora Lo Furno Rosario Giuffrida Giovanni Giurdanella | 2021 | World Journal of Stem Cells2021，13，6： | 2 |
| 3 | Rectal carcinoma : CT staging with water as contrast medium显示文摘 | Angelelli G Macarini L Lupo L | 1990 | Radiology1990，177，： | 1 |
| 4 | Basiliximab versus steroids in double therapy immunosuppression in liver transplantation: a prospective randomized clinical trial 显示文摘 | Lupo L Panzera P Tandoi F etal | 2008 | Transplantation2008，86，7： | 1 |
| 5 | Solid-state dye-sensitized mesoporous TiO2 solar cells with high photon-to-electron conversion efficiencies显示文摘 | Bach U Lupo D Comte P Moser J E Weiss(o)rtel F Salbeck J Spreitzer H Gr(a)tzel M | | 0，，： | 1 |
| 6 | Antioxidants and vitamins in cosmetics显示文摘 | Lupo M P | 2001 | Clin Dermatol2001，19，4： | 1 |
| 7 | Tumor-secretedlysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts 显示文摘 | Mazzocca A Dituri F Lupo L | 2011 | Hepatology2011，54，3： | 1 |
| 8 | Medullary sponge kidney (Lenarduzzi-Cacchi-Ricci disease):a Padua Medical School discovery in the 1930s显示文摘 | Gambaro G Feltrin GP Lupo A | | 0，，04： | 1 |
| 9 | The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with gliomadagger显示文摘 | Lupo JM Molinaro AM Essock-Burns E | 2015 | Neuro Oncol2015，34，4： | 1 |
| 10 | The entirely subcutaneous defibrillator-a new generation and future expectations显示文摘 | Ali H Lupo P Cappato R | 2015 | Arrhythm Electrophysiol Rev2015，4，2： | 1 |
| 11 | Primary IgA nephropathy is more severe in TGF-beta1 high secretor patients显示文摘 | Brezzi B Del Prete D Lupo A | 2009 | J Nephrol2009，22，6： | 1 |
| 12 | Solid - state dye - sensitized mesoporous TiO2 solar cells with high photon - to - electron conversion efficiencies显示文摘 | Bach U Lupo D Graetzel M | 1998 | Nature1998，395，6702： | 1 |
| 13 | Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging显示文摘 | Cha S Lupo JM Chen MH | 2007 | AJNR Am J Neuroradiol2007，28，6： | 1 |
| 14 | Pancreatic encephalopathy:a 7-year follow-up case report and review of the literature显示文摘 | Ruggieri RM Lupo I Piecoli F | 2002 | Neurol Sei2002，23，4： | 1 |
| 15 | Rectal carcinoma: CT staging with water as constrast medium显示文摘 | Angelelli G Macarini L Lupo L | 1990 | Radiology1990，177，2： | 1 |
| 16 | Microscopic vascular invasion deteczed by anti-CD34 immuno histochemistry as a predictor of recurrence of hepatocellular carcinoma after liver transplantation显示文摘 | SalizzoniM Romagnoli R Lupo F | 2003 | Transplantation2003，76，： | 1 |
| 17 | Solid-state dye-sensitized mesopoions TiO2 solar cells with high photon-to-electron conversion efficiencies显示文摘 | Bach U Lupo D Comte P | 1998 | Nature1998，395，： | 1 |
| 18 | Rectal carcinoma: CT staging with water as contrast medium 显示文摘 | Angelelli G Macarini L Lupo L | 1990 | Radiology1990，177，2： | 1 |
| 19 | Primary IgA ne- phropathy is more severe in TGF-betal high secretor pa- tients显示文摘 | Brezzi B Del Prete D Lupo A | 2009 | Nephrol2009，22，6： | 1 |
| 20 | Maternal and off- spring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia显示文摘 | NOUSOME D LUPO P J OKCU M F | 2013 | Leukemia Res2013，37，5： | 1 |
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