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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes显示文摘Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings.Genetically-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal resolution.We report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in vivo.We describe the design,fabrication,and assembly of low-noise,multisite/multicolor optoelectrodes.Each shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design requirements.To better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μW.We implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW illumination.We highlight the potential use of this technology for functional dissection of neural circuits. | Komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon | 2018 | Microsystems & Nanoengineering2018，4，1： | 8 |
| 3 | Modulation of long- term memory for object recognition via HDAC inhibition 显示文摘 | STEFANKO D P BARRETT R M LY A R | 2009 | Proc Nail Acad Sci U S A2009，106，23： | 1 |
| 4 | Effects of expression level of DNA repair-related genes involved in the NHEJ path- way on radiation-induced cognitive impairment 显示文摘 | ZHANG LY CHEN LS SUN R | 2013 | Radiat Res2013，54，2： | 1 |
| 5 | Isolation and structural elucidation of some glycosides from the rhizomes of smaller galangal (Alpinia officinarum Hance) 显示文摘 | LY T N YAMAUCHI R SHIMOYAMADA M | 2002 | Journal of Agricultural and Food Chemistry2002，50，17： | 1 |
| 6 | Use of HRP-2-based rapid diag- nostic test for Plasmodiumfolciparum malaria: assessing accuracy and cost effectiveness in the villages of Dielmo and Ndiop, Sene- gal显示文摘 | Ly AB Tall A Perry R | 2010 | Malar J2010，9，： | 1 |
| 7 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 8 | Activation of the ran GTPase is sub- ject to growth factor regulation and can give rise to cellular trans- formation显示文摘 | Ly TK Wang J Pereira R | 2010 | J Biol Chem2010，285，8： | 1 |
| 9 | Differential expression of GRK isoforms in nonmalig-nant and malignant human granulosa cells显示文摘 | King DW Steinmetz R Wagoner HA Hannon TS Chen LY Eug-ster EA | 2003 | Endocrine2003，22，2： | 1 |
| 10 | Protective effects of endomor- phins, endogenous opioid peptides in the brain, on human low density Iipoprotein oxidation 显示文摘 | Lin X Xue LY Wang R | 2006 | FEBS Journal2006，273，： | 1 |
| 11 | An MC3T3-E1 cell line bi- omembrane extraction and HPLC-ESI-MS(n) method for simulta- neous analysis of potential anti-osteoporosis eomponents of Epime- dium korcanum 显示文摘 | WANG R LUO JG KONG LY | 2012 | Chromatographia2012，75，1112： | 1 |
| 12 | Corrigendum: A new tabu search algorithm for the open vehicle routing problem 显示文摘 | Fu Z Eglese R Li LY | 2006 | Journal of the Operational Research Society2006，57，8： | 1 |
| 13 | PAX6,paired domain influences sequence recognition by the homeodomain显示文摘 | Mishra R Gorlov IP Chao LY | 2002 | J Biol Chem2002，277，49： | 1 |
| 14 | The mitochondrial membrane potential (deltapsi(m显示文摘 | LY J D GRUBB D R LAWEN A | | 0，，02： | 1 |
| 15 | On the TRAIL tosuccessful cancer therapy? Predicting and counteracting resistanceagainst TRAIL-based therapeutics显示文摘 | Dimberg LY Anderson CK Camidge R | 2013 | Oncogene2013，32，11： | 1 |
| 16 | Interracial supramo显示文摘 | McNa Forst er R J Keyes T E | 2009 | Phys ChemChemPhys2009，11，5： | 1 |
| 17 | Isolation and characterization of rosmarinic acid oligomers in Celastrus hindsii Benth leaves and their antioxidative activity 显示文摘 | LY T N SHIMOYAMADA M YAMAUCHI R | 2006 | Journal of Agricultural and Food Chemistry2006，54，11： | 1 |
| 18 | Plasma fibrin D-dimer levels correlate with tumour volume, progression rate and survival in patients with metastatic breast cancer显示文摘 | Dirix LY Salgado R Weytjens R | 2002 | Br J Cancer2002，86，3： | 1 |
| 19 | Selective removal of copper andlead ions by diethylenetriamine-functionalized adsorbent :behaviors and mechanisms 显示文摘 | Liu C K Bai R B Ly Q S | 2008 | Water Research2008，42，： | 1 |
| 20 | Gamma-glutamyl carboxyl- ase (GGCX) microsatellite and warfarin dosing 显示文摘 | Chen LY Eriksson N Gwilliam R | 2005 | Blood2005，106，10： | 1 |
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